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Chemosensors
Special Issues
Advanced Biosensors for Diagnostic Applications
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Advanced Biosensors for Diagnostic Applications

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "(Bio)chemical Sensing".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1875

Special Issue Editors

Dr. Mariagrazia Lettieri

E-Mail Website
Guest Editor
Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Banchi di Sotto 55, 53100 Siena, Italy
Interests: biosensors; bioanalytical assays; sensors
Special Issues, Collections and Topics in MDPI journals
Dr. Marco Consumi

E-Mail Website
Guest Editor
Associate Professor, Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
Interests: biosensors; smart biomaterials; 3D-bioprinting; HPLC-MS; ICP-MS; IRMS; ToF-SIMS; chemometrics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biosensors offer a powerful tool for the rapid, sensitive, and specific detection of biomarkers associated with diseases. These devices work by converting a biological response into a measurable signal, which can then be quantified to provide crucial information about a patient's health status. Biosensors have revolutionized the field of medical diagnostics by enabling point-of-care testing (POCT), reducing the time and cost of laboratory analyses. They are particularly useful for detecting biomarkers for diseases such as cancer, diabetes, infectious diseases, and cardiovascular disorders. The ability to miniaturize biosensors has also allowed for their integration into wearable devices, facilitating continuous health monitoring. One of the key advantages of biosensors in diagnostics is their potential for real-time detection, which is crucial for timely medical interventions. Furthermore, advancements in nanotechnology and biochemistry are continuously enhancing the sensitivity and specificity of biosensors, making them even more valuable in early disease detection and personalized medicine. As the field evolves, biosensors are expected to play an even larger role in improving healthcare outcomes globally.

Dr. Mariagrazia Lettieri
Dr. Marco Consumi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • smart biosensors
  • point-of-care devices
  • diagnostic applications
  • biomarkers detection

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Published Papers (2 papers)

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16 pages, 3089 KiB  
Article
Electrochemical Pretreatment and Functionalization of Pencil Graphite Electrodes for Enhanced Transducer Performance in Biosensing
by Rafael Mendes Coelho, Alexandre Rafael Moraes da Silva, Geycson Figueiredo Dias, Danilo Bretas de Oliveira, Arnaldo César Pereira, Diego Leoni Franco and Lucas Franco Ferreira
Chemosensors 2025, 13(3), 84; https://doi.org/10.3390/chemosensors13030084 - 2 Mar 2025
Viewed by 703
Abstract
This study aimed to optimize the electrochemical pretreatment and functionalization of pencil graphite electrodes (PGEs) for the performance evaluation of a transducer applied in initial studies in the development of an immunosensor for vaccinia virus (VACV) detection. The effects of the applied potential, [...] Read more.
This study aimed to optimize the electrochemical pretreatment and functionalization of pencil graphite electrodes (PGEs) for the performance evaluation of a transducer applied in initial studies in the development of an immunosensor for vaccinia virus (VACV) detection. The effects of the applied potential, duration, and supporting electrolyte type and concentration on PGE activation were investigated. Functionalization using a polymeric film derived from 2-hydroxybenzamide (2-HXB) was optimized by varying the applied potential, deposition time, and monomer concentration. Optimal activation conditions were found to be +0.90 V in 0.02 M of H2SO4 for 300 s, promoting the formation of hydrogenated groups and increasing electrode wettability. For electropolymerization, +1.20 V for 300 s with a 2-HXB concentration of 2.50 mM provided the best results, ensuring proper film formation and adhesion. Scanning electron microscopy revealed a rough, sheet-like surface on the polished PGE, while energy dispersive spectroscopy confirmed poly(2-HXB) adsorption through increased oxygen and nitrogen content on the functionalized electrode. The optimized pretreatment and functionalization conditions significantly influenced the response of the transducer used for VACV detection, demonstrating its crucial role in device development. These findings contribute to the advancement of inexpensive and effective electrochemical transducers and highlight the importance of pretreatment and modification of PGEs in biosensing applications. Full article
(This article belongs to the Special Issue Advanced Biosensors for Diagnostic Applications)
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14 pages, 1864 KiB  
Article
Electrochemical Immunosensor Prototype for N-Terminal Natriuretic Peptide Detection in Human Saliva: Heart Failure Biomedical Application
by Abdoullatif Baraket, El Kahina Ghedir, Nadia Zine, Nicole Jaffrezic-Renault, Abdellatif Aarfane, Hamid Nasrellah, Fouad Belhora, Francisco Palacio Bonet, Joan Bausells and Abdelhamid Errachid
Chemosensors 2025, 13(2), 66; https://doi.org/10.3390/chemosensors13020066 - 13 Feb 2025
Viewed by 936
Abstract
NT-proBNP is the gold standard biomarker for early diagnostics of heart failure, disease prevention, and stratified and individualized patient care. In this work, we aim to develop a novel ultra-sensitive immunosensor for direct NT-proBNP detection in human artificial saliva (AS), which represents an [...] Read more.
NT-proBNP is the gold standard biomarker for early diagnostics of heart failure, disease prevention, and stratified and individualized patient care. In this work, we aim to develop a novel ultra-sensitive immunosensor for direct NT-proBNP detection in human artificial saliva (AS), which represents an intriguing biological matrix potentially rich in biomarkers. The immunosensor will enhance the sensitivity of detection, reduce measurement time, and enable the simultaneous detection of various biomarkers. The developed biosensor, based on gold working microelectrodes (WEs), was biofunctionalized using 4-carboxymethyl aryl diazonium (CMA) to immobilize anti-NT-proBNP antibodies. The deposition of CMA onto the gold surface of the microelectrodes was accomplished using cyclic voltammetry (CV). The binding between NT-proBNP antibodies and NT-proBNP antigens was tracked using electrochemical impedance spectroscopy (EIS) in conjunction with the standard addition method. A linear detection response within the range of 1–20 pg/mL for NT-proBNP detection in PBS and artificial saliva was demonstrated, with good selectivity in the presence of other potential interfering biomarkers (interleukin 6 (IL-6), interleukin 10 (IL-10), and interleukin 1 β (IL-1β)). The developed immunosensor shows great promise for rapid and accurate analysis in biomedical applications. Full article
(This article belongs to the Special Issue Advanced Biosensors for Diagnostic Applications)
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