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Chemosensors, Volume 13, Issue 12

2025 December - 31 articles

Cover Story: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are emerging contaminants of global concern, requiring sensitive and highly selective detection methods. Stringent regulations imposed by the Environmental Protection Agency drive the development of novel PFAS sensors. Molecularly imprinted polymers and immunoassays are promising approaches due to their specific interactions with target molecules, leading to measurable optical or electrochemical responses. Various nanomaterials, including metal oxide nanoparticles, carbon-based materials such as carbon dots, polymer coatings, and MXenes, have been explored; however, many approaches still fail to achieve adequate limits of detection, sensitivity, or selectivity. This contribution reviews recent advances in nanomaterial-based PFAS sensors, emphasizing strategies to improve sensitivity, selectivity, and reliability in complex matrices. View this paper
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Articles (31)

  • Article
  • Open Access
424 Views
16 Pages

Chrysanthemum, a traditional medicinal and edible plant, possesses diverse health-promoting properties attributed to its rich profile of bioactive compounds. However, the intrinsic quality, influenced by the composition of fundamental components like...

  • Article
  • Open Access
552 Views
16 Pages

Eco-Friendly Synthesis and Paper Immobilization of AgNPs for Portable Colorimetric Detection of Hg2+ in Water

  • Nevena Radivojević,
  • Sanja Knežević,
  • Stefan Graovac,
  • Vladimir Rajić,
  • Tamara Terzić,
  • Nebojša Potkonjak,
  • Tamara Lazarević-Pašti and
  • Vedran Milanković

Mercury’s severe toxicity and persistence demand fast, low-cost, and sustainable detection. In this work, a Juglans regia ethanolic extract is introduced as an efficient biogenic reducing and stabilizing agent for the green synthesis of silver...

  • Review
  • Open Access
765 Views
24 Pages

Harmful substances in food and agricultural environments pose significant risks to human health, necessitating the development of sensitive detection technologies. Electrochemical sensors are ideal for rapid monitoring because of their low cost, high...

  • Article
  • Open Access
588 Views
12 Pages

Detection of Mercury Ions Using Graphene Nanoribbon-DNA Sensors Fabricated via Template Methods

  • Jiaojiao Da,
  • Haixia Shi,
  • Vesna Antic,
  • Milica Balaban,
  • Bing Xie and
  • Li Gao

To enhance the sensitivity of graphene-DNA sensors for Hg2+ detection, a novel graphene nanoribbon-DNA sensor was fabricated using a template-assisted approach. Silicon nanowires served as templates to decorate the graphene device, followed by plasma...

  • Article
  • Open Access
609 Views
14 Pages

Scandium-modified carbon dots (Sc-oCDs) were synthesized in this work through a solid-phase approach. The prepared Sc-oCDs exhibited excitation-independent emission properties, as well as photostability against pH, ionic strength, and UV irradiation....

  • Review
  • Open Access
741 Views
27 Pages

Recent Progress in Nanomaterials for Electrochemical Sensing of Natural Bioactive Compounds

  • Branka B. Petković,
  • Miloš Ognjanović and
  • Dalibor M. Stanković

The market for bioactive compounds of natural origin has expanded greatly over the past few years. These compounds can be found as individual supplements or food additives. Due to the importance of this market, incorrect data on their composition can...

  • Article
  • Open Access
811 Views
10 Pages

Polymer Electrolyte-Gated Organic Electrochemical Transistors for Bioinspired Neuromorphic Computing

  • Banghua Wu,
  • Lin Gao,
  • Yujie Peng,
  • Changjian Liu,
  • Canghao Xu,
  • Haihong Guo,
  • Yong Huang and
  • Junsheng Yu

Organic electrochemical transistors (OECTs) are compelling artificial synapses because mixed ionic–electronic coupling and transport enables low-voltage, analog weight updates that mirror biological plasticity. Here, we engineered solid-state,...

  • Review
  • Open Access
4,206 Views
52 Pages

The rapid emergence of novel psychoactive substances (NPSs) after 2020 has created one of the most dynamic analytical challenges in modern forensic science. Hundreds of new synthetic cannabinoids, synthetic cathinones, synthetic opioids, hallucinogen...

  • Article
  • Open Access
479 Views
18 Pages

Development and Application of Online Rapid Monitoring Devices for Volatile Organic Compounds in Soil–Water–Air Systems

  • Xiujuan Feng,
  • Haotong Guo,
  • Jing Yang,
  • Chengliang Dong,
  • Fuzhong Zhao and
  • Shaozhong Cheng

To overcome the limitations of lengthy laboratory testing cycles and insufficient on-site responsiveness, this study developed an online rapid monitoring device for volatile organic compounds (VOCs) in soil–water–air systems based on phot...

  • Article
  • Open Access
874 Views
21 Pages

A Machine Learning-Based Calibration Framework for Low-Cost PM2.5 Sensors Integrating Meteorological Predictors

  • Xuying Ma,
  • Yuanyuan Fan,
  • Yifan Wang,
  • Xiaoqi Wang,
  • Zelei Tan,
  • Danyang Li,
  • Jun Gao,
  • Leshu Zhang,
  • Yixin Xu and
  • Yongzhe Huang
  • + 3 authors

Low-cost sensors (LCSs) have rapidly expanded in urban air quality monitoring but still suffer from limited data accuracy and vulnerability to environmental interference compared with regulatory monitoring stations. To improve their reliability, we p...

  • Article
  • Open Access
422 Views
13 Pages

Ultrasonic-assisted maceration and supplementation with glutathione-enriched inactive dry yeast (g-IDY) represent promising strategies to optimize the quality of fermented fruit wines. This study systematically investigated the synergistic effects of...

  • Article
  • Open Access
556 Views
17 Pages

Laser-Trimmed, Surface-Functionalized Four-Bore CFMs Enable Co-Detection of Neurochemicals and Toxic Metal Ions

  • Navoda Udawaththa,
  • Ashley Daninger,
  • Noel Manring,
  • Valentina Guillen,
  • Gene Koifman and
  • Pavithra Pathirathna

Simultaneous detection of multiple neurochemicals and toxic metal ions in real time remains a major analytical challenge in neurochemistry and environmental sensing. In this study, we present a novel, biocompatible, laser-trimmed four-bore carbon fib...

  • Review
  • Open Access
798 Views
31 Pages

The accurate monitoring of metal ions is essential for applications that include environmental protection, food safety, and biomedical diagnostics. These areas depend on highly sensitive and selective methods for detecting both toxic and biologically...

  • Review
  • Open Access
1 Citations
1,068 Views
37 Pages

Molecularly Imprinted Polymer (MIP)-based sensors have gained increasing attention in the field of food safety analysis due to their unique ability to selectively recognize and quantify chemical contaminants and allergens with interesting sensitivity...

  • Review
  • Open Access
1,605 Views
23 Pages

Tracking PFAS Using Nanomaterial-Based Sensors: Limitations, Advances, and Challenges

  • Anđela Gavran,
  • Snežana Uskoković-Marković,
  • Bojana Nedić Vasiljević,
  • Aleksandra Janošević Ležaić,
  • Nemanja Gavrilov,
  • Maja Milojević-Rakić and
  • Danica Bajuk-Bogdanović

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are emerging contaminants of global concern, requiring sensitive and highly selective detection methods. Stringent demands imposed by the Environmental Protection Agency, with maximum contaminant l...

  • Article
  • Open Access
456 Views
12 Pages

Zinc sulfide nanomaterials (ZnS NMs) are widely used in many important technological applications, and the performance efficiency is determined by the nanostructure, size, and shape. This indicates that achieving a desirable surface architecture is p...

  • Article
  • Open Access
1 Citations
1,070 Views
19 Pages

Plasmonic Nanopore Sensing to Probe the DNA Loading Status of Adeno-Associated Viruses

  • Scott Renkes,
  • Steven J. Gray,
  • Minjun Kim and
  • George Alexandrakis

Adeno-associated viruses (AAVs) are a leading vector for gene therapy, yet their clinical utility is limited by the lack of robust quality control methods to distinguish between empty (AAVempty), partially loaded (AAVpartial), and fully DNA loaded (A...

  • Article
  • Open Access
1 Citations
580 Views
21 Pages

Spectroscopic Analysis for the Characterization of 3D-Printed Zinc Supplements for Tailored Veterinary Treatment

  • Neda Gavarić,
  • Nemanja Todorović,
  • Senka Popović,
  • Ivan Božić,
  • Aleksa Vojnović,
  • Nataša Milošević and
  • Mladena Lalić-Popović

Background: Individualized care in veterinary practice optimizes pharmaceutical dose regimens, facilitates disease prevention, and supports animal health by considering the animal’s individual profile. Three-dimensional (3D) printing is a suita...

  • Article
  • Open Access
533 Views
15 Pages

Carbon Quantum Dot–Supported Nickel Nanoparticles as a Synergistic Interface for Electrochemical Creatinine Sensing

  • Velia Osuna,
  • César Leyva-Porras,
  • Rocio B. Dominguez,
  • Omar Isaac Torres-Soto,
  • Alejandro Vega-Rios,
  • Erasto Armando Zaragoza-Contreras and
  • Claudia I. Piñón-Balderrama

We report a non-enzymatic electrochemical sensing platform for creatinine based on a nickel-nanoparticle/carbon-quantum-dot (NiNP–CQD) hybrid interface. In this system, the analytical signal originates from the direct electrocatalytic oxidation of cr...

  • Article
  • Open Access
535 Views
14 Pages

Silver Nanowires with Efficient Peroxidase-Emulating Activity for Colorimetric Detection of Hydroquinone in Various Matrices

  • Huda Salem AlSalem,
  • Sara Naif Alharbi,
  • Rabeea D. Abdel-Rahim,
  • Adham M. Nagiub and
  • Mohamed A. Abdel-Lateef

Hydroquinone is a phenolic compound widely used in industry and cosmetics, yet its toxicity has raised global environmental and health concerns. It has been listed by both the US EPA and the European Union as a priority contaminant for monitoring in...

  • Article
  • Open Access
690 Views
21 Pages

From Bench to Bedside: Validation of an ELISA Analytical Method for the Determination of Ricin in Biological Samples and Clinical Data on Related Intoxications

  • Antonella Rotolo,
  • Martina Pes,
  • Giovanni Solarino,
  • Elisa Roda,
  • Azzurra Schicchi,
  • Davide Lonati,
  • Filippo Uberti,
  • Carlo A. Locatelli and
  • Daniele Merli

Accidental and deliberate poisoning by Ricinus communis, a wild plant cultivated for castor oil, has been known for centuries. Seeds contain one of the deadliest known plant toxins, ricin, along with its dimer RCA120. Due to its toxicity and ease of...

  • Article
  • Open Access
499 Views
11 Pages

Hemicyanine-Based Fluorescent Probes for Cysteine Detection in Cellular Imaging and Food Samples

  • Wenqi Jiang,
  • Quanping Diao,
  • Weiwei Luo,
  • Linlin Lv,
  • Tiechun Li,
  • Qingwang Min,
  • Jinxiu Bing and
  • Majie Zhang

Cysteine (Cys) is an essential thiol in food and biological systems, yet its selective quantification remains challenging due to interference from structurally related analytes such as homocysteine (Hcy) and glutathione (GSH). Here, we report a hemic...

  • Article
  • Open Access
856 Views
15 Pages

Using pH Value as a Discriminating Feature for Scotch Whisky Authentication in Taiwan

  • Ting-Chia Chang,
  • Min-You Wu,
  • Hsiao-Wen Huang and
  • Wei-Tun Chang

While pH possesses inherent chemical significance and potential forensic value in Scotch whisky authentication, it has previously lacked a statistically rigorous exclusionary standard. This study addressed this gap by performing statistical distribut...

  • Review
  • Open Access
1,146 Views
36 Pages

Organic field-effect transistor (OFET) biosensors have emerged as a transformative technology for clinical biomarker detection, offering unprecedented sensitivity, selectivity, and versatility in point-of-care (POC) diagnostics. This review examines...

  • Article
  • Open Access
543 Views
12 Pages

An indirect, novel, fast, and facile assay was developed for the colorimetric determination of fluoride anions using 96-well plates. The proposed method relies on the colorimetric degradation caused by fluoride ions after their reaction with the iron...

  • Article
  • Open Access
513 Views
16 Pages

Saliva is a biological fluid that can be found at various crime scenes and mainly presents two challenges for the forensic analysis: its identification and the estimation of the time since deposition (TSD). In this study, the performance of Partial L...

  • Article
  • Open Access
675 Views
15 Pages

Unrefined vegetable oils are an important source of bioactive compounds with beneficial effects on health. Therefore, confirming the biological identity of oils is important for ethical and economic reasons. In this study, a method was developed for...

  • Article
  • Open Access
739 Views
19 Pages

A novel, green, stability-illustrating HPLC-DAD method was validated for the simultaneous analysis of menadione (MND), dimetridazole (DMT), and sulfadimethoxine sodium (SLF) in a veterinary powder for the first time. These compounds are commonly comb...

  • Article
  • Open Access
1 Citations
640 Views
19 Pages

XPS Study of Nanostructured Pt Catalytic Layer Surface of Gas Sensor Dubbed GMOS

  • Hanin Ashkar,
  • Sara Stolyarova,
  • Tanya Blank and
  • Yael Nemirovsky

The long-term reliability of catalytic gas sensors is strongly influenced by changes in the chemical state and cleanliness of the catalyst surface. In this work, we investigate the surface composition and stability of the platinum (Pt) nanoparticle c...

  • Article
  • Open Access
897 Views
12 Pages

The complexity of the milk matrix, driven by its lipid-rich composition, complicates pesticide residue analysis. This study developed a simplified and robust analytical procedure for the quantification of 250 pesticides in cow’s milk. Sample pr...

  • Article
  • Open Access
711 Views
17 Pages

Development of a Sensitive and Cost-Effective MWCNTs/CCE Sensor for Electrochemical Determination of Prednisolone in Pharmaceuticals and Blood Serum

  • Maksim V. Lipskikh,
  • Elena I. Korotkova,
  • Alina V. Erkovich,
  • Margarita S. Mamina,
  • Muhammad Saqib,
  • Olga I. Lipskikh and
  • Pradip K. Kar

A sensitive and cost-effective voltammetric sensor using a carbon-containing electrode (CCE) with a renewable surface modified with multi-walled carbon nanotubes (MWCNTs) was developed for the determination of prednisolone in pharmaceuticals and bloo...

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Chemosensors - ISSN 2227-9040