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Chemosensors
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Feature Papers on Luminescent Sensing (Second Edition)
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Feature Papers on Luminescent Sensing (Second Edition)

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Analytical Methods, Instrumentation and Miniaturization".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 2793

Special Issue Editors

Prof. Dr. Jin-Ming Lin

E-Mail Website
Guest Editor
Beijing Key Laboratory of Microanalytical Methods and Instrumentation, Department of Chemistry, Tsinghua University, Beijing 100084, China
Interests: bio- and environmental analytical chemistry; microfluidics and mass spectrometry for cell analysis; chemiluminescence/fluorescence immunoassay for protein and DNA analysis; analytical methods for negative oxygen ions and reactive oxygen species (ROS); sample pretreatment for mass spectrometry and chromatography analysis; development of analytical instrumentation
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Qiongzheng Hu

E-Mail Website
Guest Editor
Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
Interests: liquid crystals; sensors; polymer dots; fluorescent materials; paper-based devices
Special Issues, Collections and Topics in MDPI journals
Dr. Mashooq Khan

E-Mail Website
Guest Editor
Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
Interests: sensors and biosensors; liquid crystals; microfluidics; single cell imaging; smart polymers

Special Issue Information

Dear Colleagues,

Luminescent sensors act as critical detection tools in a broad range of areas in biology, medicine, environmental care, etc. This Special Issue will provide a forum for the latest research activities in the field of luminescent sensors, such as bioluminescent sensors, chemiluminescent sensors, electrochemiluminescent sensors, sonoluminescent sensors, triboluminescent sensors, and fluorescent and phosphorescent sensors. Both review articles and original research papers are encouraged in, though not limited to, the following areas:

  • The new concepts of developing luminescent sensors;
  • The design of new luminescent materials for sensing applications;
  • The use of new materials for the development of luminescent sensors;
  • The emerging applications of luminescent sensors;
  • State-of-the-art technologies to improve the performance of luminescent sensors;
  • The fabrication of custom-made luminescent sensors;
  • The development of luminescence-based instruments for sensing applications;

Prof. Dr. Jin-Ming Lin
Prof. Dr. Qiongzheng Hu
Dr. Mashooq Khan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioluminescent sensors
  • chemiluminescent sensors
  • electrochemiluminescent sensors
  • sonoluminescent sensors
  • triboluminescent sensors
  • fluorescent sensors
  • phosphorescent sensors

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

13 pages, 1923 KB  
Article
Construction of a Photonic Crystal (PC) Film Sensing Platform Based on Calcium Alginate Hydrogel for the Trichlorfon Detection
by Junjie Ren, Xia Li, Zhongxing Wang and Li Yu
Chemosensors 2025, 13(8), 306; https://doi.org/10.3390/chemosensors13080306 - 13 Aug 2025
Viewed by 346
Abstract
Trichlorfon, an organophosphorus pesticide widely used in agriculture and other fields, poses a severe risk to both food safety and human health. We developed a photonic crystal film sensing platform for detecting trichlorfon, a hazardous organophosphorus pesticide. The method exploits trichlorfon’s inhibition of [...] Read more.
Trichlorfon, an organophosphorus pesticide widely used in agriculture and other fields, poses a severe risk to both food safety and human health. We developed a photonic crystal film sensing platform for detecting trichlorfon, a hazardous organophosphorus pesticide. The method exploits trichlorfon’s inhibition of acetylcholinesterase (AChE). Normally, AChE catalyzes acetylcholine hydrolysis to produce acetic acid, which decomposes CaCO3 to release Ca2+. This triggers calcium alginate hydrogel formation, increasing solution viscosity and trapping water. When trichlorfon inhibits AChE, hydrogel formation fails, leaving the solution in a low-viscosity sol state with abundant free water. Immersing the film in trichlorfon-containing sodium alginate solutions causes water absorption and film swelling due to free water. Higher trichlorfon concentrations reduce hydrogel formation, increase free water, and amplify film swelling, resulting in proportionally higher reflectivity. The platform demonstrates a wide linear range (1–250 ng/mL) and a low detection limit (0.4 ng/mL) for trichlorfon. Successful analysis of real samples confirms its practicality for residue detection. This label-free thin-film sensor shows significant potential for monitoring trichlorfon and other organophosphorus pesticides. Full article
(This article belongs to the Special Issue Feature Papers on Luminescent Sensing (Second Edition))
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14 pages, 6958 KB  
Article
A pH-Responsive Liquid Crystal-Based Sensing Platform for the Detection of Biothiols
by Xianghao Meng, Ronghua Zhang, Xinfeng Dong, Zhongxing Wang and Li Yu
Chemosensors 2025, 13(8), 291; https://doi.org/10.3390/chemosensors13080291 - 6 Aug 2025
Viewed by 374
Abstract
Biothiols, including cysteine (Cys), homocysteine (Hcy), and glutathione (GSH), are crucial for physiological regulation and their imbalance poses severe health risks. Herein, we developed a pH-responsive liquid crystal (LC)-based sensing platform for detection of biothiols by doping 4-n-pentylbiphenyl-4-carboxylic acid (PBA) into [...] Read more.
Biothiols, including cysteine (Cys), homocysteine (Hcy), and glutathione (GSH), are crucial for physiological regulation and their imbalance poses severe health risks. Herein, we developed a pH-responsive liquid crystal (LC)-based sensing platform for detection of biothiols by doping 4-n-pentylbiphenyl-4-carboxylic acid (PBA) into 4-n-pentyl-4-cyanobiphenyl (5CB). Urease catalyzed urea hydrolysis to produce OH−, triggering the deprotonation of PBA, thereby inducing a vertical alignment of LC molecules at the interface corresponding to dark optical appearances. Heavy metal ions (e.g., Hg2+) could inhibit urease activity, under which condition LC presents bright optical images and LC molecules maintain a state of tilted arrangement. However, biothiols competitively bind to Hg2+, the activity of urease is maintained which enables the occurrence of urea hydrolysis. This case triggers LC molecules to align in a vertical orientation, resulting in bright optical images. This pH-driven reorientation of LCs provides a visual readout (bright-to-dark transition) correlated with biothiol concentration. The detection limits of Cys/Hcy and GSH for the PBA-doped LC platform are 0.1 μM and 0.5 μM, respectively. Overall, this study provides a simple, label-free and low-cost strategy that has a broad application prospect for the detection of biothiols. Full article
(This article belongs to the Special Issue Feature Papers on Luminescent Sensing (Second Edition))
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12 pages, 9594 KB  
Article
An Electrochemical Sensor Based on AuNPs@Cu-MOF/MWCNTs Integrated Microfluidic Device for Selective Monitoring of Hydroxychloroquine in Human Serum
by Xuanlin Feng, Jiaqi Zhao, Shiwei Wu, Ying Kan, Honemei Li and Weifei Zhang
Chemosensors 2025, 13(6), 200; https://doi.org/10.3390/chemosensors13060200 - 1 Jun 2025
Viewed by 847
Abstract
Hydroxychloroquine (HCQ), a cornerstone therapeutic agent for autoimmune diseases, requires precise serum concentration monitoring due to its narrow therapeutic window. Current HCQ monitoring methods such as HPLC and LC-MS/MS are sensitive but costly and complex. While electrochemical sensors offer rapid, cost-effective detection, their [...] Read more.
Hydroxychloroquine (HCQ), a cornerstone therapeutic agent for autoimmune diseases, requires precise serum concentration monitoring due to its narrow therapeutic window. Current HCQ monitoring methods such as HPLC and LC-MS/MS are sensitive but costly and complex. While electrochemical sensors offer rapid, cost-effective detection, their large chambers and high sample consumption hinder point-of-care use. To address these challenges, we developed a microfluidic electrochemical sensing platform based on a screen-printed carbon electrode (SPCE) modified with a hierarchical nanocomposite of gold nanoparticles (AuNPs), copper-based metal–organic frameworks (Cu-MOFs), and multi-walled carbon nanotubes (MWCNTs). The Cu-MOF provided high porosity and analyte enrichment, MWCNTs established a 3D conductive network to enhance electron transfer, and AuNPs further optimized catalytic activity through localized plasmonic effects. Structural characterization (SEM, XRD, FT-IR) confirmed the successful integration of these components via π-π stacking and metal–carboxylate coordination. Electrochemical analyses (CV, EIS, DPV) revealed exceptional performance, with a wide linear range (0.05–50 μM), a low detection limit (19 nM, S/N = 3), and a rapid response time (<5 min). The sensor exhibited outstanding selectivity against common interferents, high reproducibility (RSD = 3.15%), and long-term stability (98% signal retention after 15 days). By integrating the nanocomposite-modified SPCE into a microfluidic chip, we achieved accurate HCQ detection in 50 μL of serum, with recovery rates of 95.0–103.0%, meeting FDA validation criteria. This portable platform combines the synergistic advantages of nanomaterials with microfluidic miniaturization, offering a robust and practical tool for real-time therapeutic drug monitoring in clinical settings. Full article
(This article belongs to the Special Issue Feature Papers on Luminescent Sensing (Second Edition))
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12 pages, 2088 KB  
Article
Enzyme Inhibition-Mediated Distance-Based Paper Biosensor for Organophosphate Pesticide Detection in Food Samples
by Yulin Liu, Longzhan Dong, Qiognzheng Hu, Jingbo Chen and Mashooq Khan
Chemosensors 2025, 13(4), 147; https://doi.org/10.3390/chemosensors13040147 - 16 Apr 2025
Viewed by 846
Abstract
Organophosphate pesticides (OPs) enter the environment through various avenues, posing significant health risks. This highlights the need to monitor OPs in food and environmental samples. This study introduces an enzyme inhibition-mediated distance-based paper (EIDP) biosensor designed for naked-eye visual detection of OPs in [...] Read more.
Organophosphate pesticides (OPs) enter the environment through various avenues, posing significant health risks. This highlights the need to monitor OPs in food and environmental samples. This study introduces an enzyme inhibition-mediated distance-based paper (EIDP) biosensor designed for naked-eye visual detection of OPs in food samples. We synthesized a copper alginate (Cu-Alg) hydrogel that traps water within the gel and restricts water flow on pH paper. When incubated with acetylcholinesterase (AChE) and acetylthiocholine (ATCh), the enzyme activity of AChE on ATCh generates thiocholine, which interacts with the Cu2+ ions in the gel. This interaction alters the gel’s 3D structure, releasing the trapped water onto the pH paper. Conversely, when AChE is exposed to OPs, its activity is inhibited, limiting the water flow from the gel. As a result, OPs are quantified by measuring the reduction in water flow distance within a linear range of 18 to 105 ng/mL, with a lower detection limit of 18 ng/mL. The EIDP biosensor exhibits high selectivity for OP detection and successfully analyzes OPs in pumpkin and rice samples, achieving percent recoveries ranging from 93% to 103%. This method offers a straightforward, portable, instrument-free, and cost-effective solution for detecting OPs in food samples. Full article
(This article belongs to the Special Issue Feature Papers on Luminescent Sensing (Second Edition))
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