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Chemosensors, Volume 13, Issue 9

2025 September - 39 articles

Cover Story: Chemical sensors are undergoing a paradigm shift driven by the convergence of nanomaterials, advanced fabrication strategies, and state-of-the-art characterization techniques. This review highlights U.S.-led advances from 2019 to 2025, focusing on graphene derivatives, MXenes, MOFs, carbon nanotubes, and hybrid composites that enable ppb-to-ppt detection, rapid response, and high stability. We examine material innovations, device miniaturization, and real-world deployments in healthcare, environmental monitoring, food safety, and industry, outlining challenges and prospects toward intelligent, sustainable sensing platforms. View this paper
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Articles (39)

  • Article
  • Open Access
1,332 Views
17 Pages

Magnetosome-Based Immunosensors for Foodborne Pathogen Detection

  • Sankar Sekar,
  • Shiva Kumar Arumugasamy,
  • Sejoon Lee,
  • Saravanan Sekar,
  • Sutha Sadhasivam,
  • Sekar Vaithilingam,
  • Nandhakumar Srinivasan,
  • Elangovan Krishnan,
  • Seung-Cheol Chang and
  • Ramalingam Manikandan

Foodborne illnesses remain a global challenge, requiring rapid and sensitive detection platforms. We developed a magnetosome-based electrochemical immunosensor for lipopolysaccharide (LPS) antigens from Escherichia coli and Salmonella typhimurium. Ma...

  • Article
  • Open Access
1,157 Views
17 Pages

Research on a Humidity Sensor Based on Polymerizable Deep Eutectic System-Modified Filter Paper

  • Mengyao Shen,
  • Bo Zhang,
  • Qi Lu,
  • Yanan Xiao,
  • Hao Shen,
  • Yi Ni,
  • Yuechen Liu and
  • Haitao Song

In recent years, paper-based humidity sensors have emerged as a highly promising technology for humidity detection. In this work, a polymerizable deep eutectic solvent (PDES) was prepared via a one-step blending method, which was applied to modify fi...

  • Review
  • Open Access
1 Citations
1,877 Views
36 Pages

Gas chromatography–mass spectrometry (GC-MS) plays a crucial role in analyzing complex water samples due to its high sensitivity, selectivity, and robustness. Recent developments have transformed GC-MS into a powerful chemosensor platform, capa...

  • Review
  • Open Access
3 Citations
3,122 Views
23 Pages

The increasing presence of heavy metals in wastewater is a growing environmental and public health concern, particularly due to their role in promoting the spread of antibiotic-resistant bacteria (ARB) through co-selection mechanisms. This review exp...

  • Review
  • Open Access
2,299 Views
34 Pages

Recent Advances in Benzodiazepine Electroanalysis

  • Mihaela-Carmen Cheregi,
  • Emilia-Elena Iorgulescu,
  • Mircea-Alexandru Comănescu,
  • Iulia Gabriela David and
  • Adelaida Sorana Trifu

Benzodiazepines are psychoactive drugs with wide clinical applications. Unfortunately, due to their sedative effects, benzodiazepines are frequently used as date rape drugs or in drug-facilitated crimes. Considering the electroactive nature of benzod...

  • Article
  • Open Access
2 Citations
1,837 Views
13 Pages

Noble Metal-Decorated In2O3 for NO2 Gas Sensor: An Experimental and DFT Study

  • Parameswari Raju,
  • Jafetra Rambeloson,
  • Dimitris E. Ioannou,
  • Abhishek Motayed and
  • Qiliang Li

Indium oxide-based gas sensors have been proven to be a promising material for detecting nitrogen dioxide (NO2) gas because of its wide bandgap and stability. In this paper, the enhancement mechanism for the sensitivity of indium oxide NO2 gas sensor...

  • Article
  • Open Access
4,968 Views
18 Pages

Investigation of Distinct Odor Profiles of Blood over Time Using Chemometrics and Detection Canine Response

  • Fantasia Whaley,
  • Valerie Albizu,
  • Jordi Cruz,
  • Rushali Dargan and
  • Lauryn DeGreeff

The detection of blood by human remains detection (HRD) canines and blood detection dogs (BDDs) is crucial to both search and rescue (SAR) and crime scene investigation. They can be used to find both missing persons and to detect otherwise undetectab...

  • Article
  • Open Access
1,077 Views
15 Pages

Nanoparticle-Coated Optical Hydrogen Sensor for Early Gas Detection of Lithium-Ion Battery Failure

  • Leonard Kropkowski,
  • Ahmad Abdalwareth,
  • Christoff Brüdigam,
  • Martin Angelmahr and
  • Wolfgang Schade

This research investigates the use of a fiber optic sensor for detecting hydrogen gas during a thermal runaway of lithium-ion batteries (LIBs). Timely detection of thermal runaway in LIBs, particularly in storage and logistics, is crucial for effecti...

  • Review
  • Open Access
1 Citations
2,232 Views
21 Pages

This investigation highlights the importance of adopting ethical and sustainable practices in chicken farming, in response to the increasing global demand for poultry products driven by the expanding world population. How ambient gases, such as hydro...

  • Article
  • Open Access
1 Citations
1,282 Views
19 Pages

Seasonal dynamics of dissolved organic matter (DOM) in agricultural ditches significantly impact carbon cycling and water quality in connected rivers. This study aimed to characterize seasonal variations in DOM composition and dynamics within hierarc...

  • Review
  • Open Access
6 Citations
3,280 Views
44 Pages

Chemical sensors have undergone transformative advances in recent years, driven by the convergence of nanomaterials, advanced fabrication strategies, and state-of-the-art characterization methods. This review emphasizes recent developments, with part...

  • Review
  • Open Access
1 Citations
2,456 Views
47 Pages

Photoelectrochemical Aptasensors for Biosensing: A Review

  • Gang Xiao,
  • Jiazheng Li,
  • Boxiang Zhao and
  • Zhao Yue

Biodetection, the basis of many biotechnologies, has rapidly developed in recent years. Among various biodetection methods, the photoelectrochemical (PEC) sensor is an emerging analytical method and has been applied in biodetection widely because of...

  • Article
  • Open Access
1,985 Views
15 Pages

High-Intensity In Situ Fluorescence Imaging of MicroRNA in Cells Based on Y-Shaped Cascade Assembly

  • Yan Liu,
  • Xueqing Fan,
  • Xinying Zhou,
  • Zhiqi Zhang,
  • Qi Yang,
  • Rongjie Yang,
  • Yingxue Li,
  • Anran Zheng,
  • Lianqun Zhou and
  • Jinze Li
  • + 1 author

MicroRNAs are closely associated with various physiological and pathological processes, making their in situ fluorescence imaging crucial for functional studies and disease diagnosis. Current methods for the in situ fluorescence imaging of microRNA p...

  • Article
  • Open Access
1 Citations
1,219 Views
16 Pages

An electrochemical aptamer sensor for the sensitive detection of aflatoxin B1 (AFB1) in corn samples was developed using nanocomposites loaded with copper nanoparticles (CuNPs) on zeolitic imidazolate framework-8 (ZIF-8), which were modified on a gla...

  • Article
  • Open Access
897 Views
16 Pages

Microchip electrophoresis (ME) has been recognized as a promising analytical technique in life sciences, disease diagnostics, and environmental monitoring due to advantages such as minimal reagent consumption, rapid analysis, and compact size. While...

  • Article
  • Open Access
1 Citations
1,088 Views
13 Pages

A Ratiometric Fluorescent Probe Based on CDs-Functionalized UiO-66 for Efficient Detection of Uric Acid

  • Hongmei Gao,
  • Yourong Zhao,
  • Yuhong Xie,
  • Yiying Wang,
  • Jie Che,
  • Daojiang Gao and
  • Zhanglei Ning

In this study, a novel carbon quantum dots-functionalized UiO-66 composite was successfully prepared via the post-synthetic modification method and further developed into a ratiometric fluorescent probe for detecting uric acid. The composite demonstr...

  • Article
  • Open Access
1 Citations
1,169 Views
20 Pages

Since methanol has a significant health hazard due to its inherent toxicity, it is urgent to develop a method capable of rapid, sensitive, and continuous monitoring of methanol. The present study successfully synthesized a NiCo2O4/MIL-Ti125 composite...

  • Article
  • Open Access
928 Views
13 Pages

Microcontact-Printed Optical Biosensor for Non-Invasive Detection of TNF-α: Point-of-Care Monitoring of Heart Failure

  • Abdoullatif Baraket,
  • Alexi Bonament,
  • Abdellatif Aarfane,
  • Hamid Nasrellah,
  • Meryem Bensemlali,
  • Joan Bausells,
  • Nicole Jaffrezic-Renault,
  • Nadia Zine and
  • Abdelhamid Errachid

Tumor Necrosis Factor-alpha (TNF-α) is a pro-inflammatory cytokine strongly associated with the early onset and progression of heart failure (HF). In this study, we present the design and fabrication of a label-free, fluorescence-based biosenso...

  • Review
  • Open Access
1 Citations
7,070 Views
35 Pages

From Volatile Profiling to Sensory Prediction: Recent Advances in Wine Aroma Modeling Using Chemometrics and Sensor Technologies

  • Fernanda Cosme,
  • Alice Vilela,
  • Ivo Oliveira,
  • Alfredo Aires,
  • Teresa Pinto and
  • Berta Gonçalves

Wine quality is closely linked to sensory attributes such as aroma, taste, and mouthfeel, all of which are influenced by grape variety, “terroir”, and vinification practices. Among these, aroma is particularly important for consumer prefe...

  • Article
  • Open Access
1,144 Views
17 Pages

Rapid and green detection of soil nutrients is essential for soil fertility and plant growth. However, traditional methods cannot meet the needs of rapid detection, and the reagents easily cause environmental pollution. Hence, we proposed a multivari...

  • Article
  • Open Access
723 Views
13 Pages

The development of high-performance electrochemical sensors is crucial for ammonia–nitrogen detection. Therefore, in this study, we successfully prepared one ternary PtNiCo nanosheet via the one-step electrodeposition technique. The ratio of H2...

  • Article
  • Open Access
1,031 Views
13 Pages

Fluorescent Assay for Salmonella Detection Based on Triangle Multivalent Aptamer-Initiated Catalytic Hairpin Assembly

  • Shu Chen,
  • Zhen Wang,
  • Wen Lu,
  • Xingxing Peng,
  • Chuanpi Wang,
  • Zhaohui Qiao and
  • Xiude Hua

Salmonella poses a severe global threat to food safety and public health, necessitating rapid, sensitive, and reliable detection methods. Conventional techniques often suffer from complexity, time consumption, cost, or limited sensitivity. To address...

  • Article
  • Open Access
776 Views
12 Pages

Abeliophyllum distichum is rich in polyphenols and flavonoids with various bioactivities; however, studies on enzymatic modifications to enhance its functional properties remain limited. This study investigated the effect of Viscozyme® L treatmen...

  • Review
  • Open Access
1,387 Views
13 Pages

This review explores the application of chemometric techniques for the authentication, characterization, and adulteration detection of Cypriot agri-food products registered under European Union quality schemes, including Protected Designation of Orig...

  • Article
  • Open Access
881 Views
12 Pages

A Carbon Black-Based Non-Enzymatic Electrochemical Sensor for the Detection of Sunset Yellow in Beverages

  • Zihui Li,
  • Wenxue Chen,
  • Qiongya Wan,
  • Haoliang Li,
  • Xuefeng Wang,
  • Pengcheng Xu,
  • Yuan Zhang,
  • Yongheng Zhu and
  • Xinxin Li

This study presents a highly sensitive non-enzymatic electrochemical sensor for detecting Sunset Yellow, a common food additive in beverages, based on palladium-cerium oxide composite decorated carbon black (CB). The sensing material was prepared by...

  • Article
  • Open Access
1 Citations
1,056 Views
20 Pages

Synthesis, Characterization, and Evaluation of Photocatalytic and Gas Sensing Properties of ZnSb2O6 Pellets

  • Jacob Morales-Bautista,
  • Héctor Guillén-Bonilla,
  • Lucia Ivonne Juárez-Amador,
  • Alex Guillén-Bonilla,
  • Verónica-María Rodríguez-Betancourtt,
  • Jorge Alberto Ramírez-Ortega,
  • José Trinidad Guillén-Bonilla and
  • María de la Luz Olvera-Amador

This work reports a low-cost, microwave-assisted wet chemistry synthesis of zinc antimonate (ZnSb2O6) powders with a trirutile structure, yielding highly homogeneous, nanometric particles. X-ray diffraction (XRD) confirmed the formation of the trirut...

  • Review
  • Open Access
3,481 Views
27 Pages

Fossils are portals to the past, providing researchers with vital information about the evolution of life on Earth throughout the geological eras. The present study synthesizes the recent trends in fossil research, emphasizing the most common techniq...

  • Article
  • Open Access
1,336 Views
14 Pages

The Classification of Synthetic- and Petroleum-Based Hydrocarbon Fluids Using Handheld Raman Spectroscopy

  • Javier E. Hodges,
  • Kailee Marchand,
  • Geraldine Monjardez and
  • Jorn Chi-Chung Yu

Hydrocarbon fluids have a widespread presence in modern society due to their role in the global energy and fuel supply. The ability to distinguish between hydrocarbon fluids from different manufacturing processes is essential in industrial and govern...

  • Article
  • Open Access
1 Citations
1,314 Views
24 Pages

This innovative study introduces an eco-conscious and cost-effective approach to synthesizing gelatin-based carbon dots (CDs) via two distinctive methods: hydrothermal processing in a muffle furnace (CDs-MF) and domestic microwave (CDs-MW). Both stra...

  • Article
  • Open Access
930 Views
14 Pages

Hydrolates are aromatic aqueous solutions saturated with volatile water-soluble compounds of essential oil. Despite their potential, hydrolates remain less explored than essential oils. In this work, the hydrolate of Pelargonium odoratissimum (L.) L&...

  • Article
  • Open Access
1,011 Views
13 Pages

Oxygen Vacancy-Engineered Cu2O@CuS p–p Heterojunction Gas Sensor for Highly Sensitive n-Butanol Detection

  • Di Zhang,
  • Zhengfang Qu,
  • Chenchen Li,
  • Huan Wang,
  • Yong Zhang,
  • Xiang Ren and
  • Rui Xu

The sensitive detection of n-butanol is of high scientific and practical importance for ensuring safety in industrial production. In this study, hollow Cu2O@CuS core–shell nanocubic heterostructures were fabricated via a multistep templating me...

  • Article
  • Open Access
795 Views
12 Pages

Multivariate Calibration for Selective Analysis of Hydrogen Sulfide and Carbon Monoxide with Thermal Modulation of the SnO2–PdO Sensor

  • Alexey Shaposhnik,
  • Pavel Moskalev,
  • Alexey Vasiliev,
  • Kirill Oreshkin,
  • Alexey Zviagin,
  • Elena Vysotskaya,
  • Sergey Turishchev and
  • Iuliia Kakuliia

In this study, multivariate data processing during thermal modulation of the SnO2–PdO gas sensor was performed using the multivariate calibration (MC) method. We propose to supplement this method with a procedure that allows the solving of prob...

  • Article
  • Open Access
1,183 Views
11 Pages

Comparison of Hydrodistillation and Headspace Solid-Phase Microextraction to Analyze Volatiles from Brazilian Propolis by GC-MS

  • Mariana Budóia Gabriel,
  • Guilherme Perez Pinheiro,
  • Leandro Wang Hantao and
  • Alexandra Christine Helena Frankland Sawaya

Propolis is a substance produced by bees from the collection of plant resins, with a chemical composition that varies according to the available flora and region, and it has several biological activities. Stingless bee propolis is often produced in r...

  • Article
  • Open Access
1,202 Views
14 Pages

A DODTA–TPB-Based Potentiometric Sensor for Anionic Surfactants: A Computational Design and Environmental Application

  • Nada Glumac,
  • Lucija Vrban,
  • Robert Vianello,
  • Marija Jozanović,
  • Maksym Fizer,
  • Marija Kraševac Sakač,
  • Raffaele Velotta,
  • Vincenzo Iannotti,
  • Bartolomeo Della Ventura and
  • Nikola Sakač
  • + 2 authors

Surfactants are used in various washing applications with potential negative environmental and health impacts. The ion-pair 1,3-dioctadecyl-1H-1,2,3-triazol-3-ium-tetraphenylborate (DODTA–TPB) was used to fabricate the potentiometric sensor for...

  • Article
  • Open Access
1,432 Views
17 Pages

Interpreting chemical analysis results to identify ignitable liquid (IL) residues in fire debris samples is challenging, owing to the complex chemical composition of ILs and the diverse sample matrices. This work investigated a transfer learning appr...

  • Article
  • Open Access
1 Citations
1,811 Views
28 Pages

Anti-Aging Potential of Illyrian Iris Rhizome Extract: Preliminary Chemical and Biological Profiling and Chemosensor Analysis via GC/MS and UHPLC-DAD-MS/MS Combined with HPTLC Bioautography

  • Ivana Stojiljković,
  • Đurđa Ivković,
  • Jelena Stanojević,
  • Jelena Zvezdanović,
  • Jelena Beloica,
  • Maja Krstić Ristivojević,
  • Dalibor Stanković,
  • Mihajlo Jakanovski and
  • Petar Ristivojević

Illyrian iris (Iris pallida subsp. illyrica (Tomm. ex Vis.) K.Richt.) is a rhizomatous geophyte, an endemic species (subspecies), occurring within a limited range along the eastern coast of the Adriatic Sea. The study presents the first in-depth chem...

  • Article
  • Open Access
2 Citations
969 Views
12 Pages

Synergistic Tuning of Active Sites and π-Conjugation in 2D Conductive MOFs Boosts Uric Acid Electrosensing

  • Yanli Liu,
  • Yifan Fu,
  • Haitong Zhang,
  • Lingyu Wang,
  • Xuejing Lin and
  • Jingjuan Liu

Uric acid (UA) detection is critical for human health monitoring, necessitating the development of electrochemical sensing electrodes suitable for physiological environments. This study evaluated four 2D conductive metal–organic frameworks (2D...

  • Article
  • Open Access
1,079 Views
24 Pages

Electrochemical Monitoring of Bisphenol A Degradation in Leachate by Trichoderma harzianum Using a Sensitive Sensor of Type SPE in Microbial Fuel Cells

  • Serge Mbokou Foukmeniok,
  • Jean-Philippe Theodore Silga,
  • Adil Ait Yazza,
  • Honorine Hortense Bougna Tchoumi,
  • Malak Dia,
  • Maxime Pontie and
  • Vladimir Urošević

This study reports the development of a simple and sensitive electrochemical sensor based on activated screen-printed electrodes modified by electrodeposition of nickel(II) tetrasulfonated phthalocyanine film (poly-NiTSPc), denoted SPE-A-polyNiTSPc,...

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Chemosensors - ISSN 2227-9040