Table of Contents
Biomolecules, Volume 10, Issue 11 (November 2020) – 122 articles
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Cover Story (view full-size image) Membrane proteins are specifically targeted to distinct microdomains of organellar membranes, which [...] Read more. Membrane proteins are specifically targeted to distinct microdomains of organellar membranes, which is essential for the proper execution of their biological functions. Yeast tetraspan protein Nce102 has been shown to migrate between domains within the plasma membrane in response to an acute drop in sphingolipid levels. We show that upon gradual aging of a yeast culture, when sphingolipid demand increases, Nce102 migrates from the plasma membrane to the membrane of a vacuole. Here, it localizes to V-ATPase-poor, i.e., ergosterol-enriched, domains. We demonstrate that Nce102 and its homolog Fhn1 modulate vacuolar morphology, dynamics, and physiology. Most prominently, the absence of either protein results in enlargement of ergosterol-rich vacuolar membrane domains and decreased stability of the V-ATPase. View this paper