EMT and Cancer

Dear Colleagues,

Epithelial-to-mesenchymal transition (EMT) is one of the most crucial mechanisms, its role has been explored and defined in both normal and pathological conditions. The EMT is tightly regulated by a variety of molecular pathways whereby epithelial cells obtain more motility by losing their apical–basal polarity and acquire a front–rear polarity that is the characteristic feature of mesenchymal cells. In spite of being vital for some normal cellular processes, cancer cells use the EMT mechanism to enhance their progression and malignancy. However, more knowledge about the role of the EMT in metastasis, its control, and its reversion is needed. To address current and future perspectives on the role of the EMT in cancer, we invite authors to submit research or review articles describing recent findings in their pathology, EMT inducers and their corresponding pathways, EMT involvement in metastasis and drug resistance, chromatin remodeling, mitochondrial remodeling, senescence, and therapeutic perspectives. Cutting-edge studies in therapeutics development and preventive strategies against EMT are highly welcome.

Potential topics in this Special Issue include but are not limited to the following:

1. Tumor progression with metastatic expansion;
2. Generation of tumor cells with stem cell properties;
3. Disruption of cell–cell adhesion and cellular polarity;
4. Remodeling of the cytoskeleton;
5. Changes in cell–matrix adhesion;
6. Tumor microenvironment;
7. Non-coding RNAs;
8. Chromatin remodeling and epigenetic modifications;
9. Regulatory networks involving transcriptional control;

Prof. Dr. Alan Prem Kumar
Guest Editor

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