Special Issue "Metal Binding Proteins 2020"

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 September 2020.

Special Issue Editor

Dr. Eugene A. Permyakov
E-Mail Website
Guest Editor
Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino 142290, Russia
Tel. 7 495 624 57 49; Fax: +7 4967 33 05 22
Interests: protein physics; luminescence (fluorescence, phosphorescence) spectroscopy of proteins; scanning and titration calorimetry of proteins; metal binding proteins; calcium binding proteins
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Special Issue Information

Dear Colleagues,

Everyone knows that the functioning of any biological system is impossible without metal ions. The ‘metals of life’ include sodium, potassium, magnesium, calcium, manganese, iron, cobalt, zinc, nickel, vanadium, molybdenum, and tungsten. Any biological system contains special proteins specifically interacting with metal ions. Metal ions play several major roles in proteins: structural, regulatory, and enzymatic. Strong binding of some metal ions increases the stability of proteins or protein domains. Some metal ions can regulate various cell processes being first, second or third messengers. Calcium is the most universal carrier of signals to cells. It regulates all important aspects of cell activity, beginning with fertilization and ending with apoptotic suicide at the end of the life cycle. Metal ions are an essential part of many enzymes and are indispensable in many catalytic reactions. 

Despite the apparent good knowledge of the structure and properties of many metal-binding proteins, many aspects of their structure and, in particular, mechanisms of their functioning are still insufficiently studied. For example, although the three-dimensional structure of many calcium-binding sites in proteins is well known, a closer look at their environment reveals common structural features in these proteins that were not previously noticed. Studying the interactions of metal binding proteins with proteins of other classes allows us to reach a better understanding of their physiological functions. Modern methods of genetic engineering and knowledge of the three-dimensional structure of metal-binding proteins allow us to study their structure and functions at a new level. The obtained fundamental knowledge can already be used in applied science. Comprehensive reviews or original research articles are most welcome.

Dr. Eugene A. Permyakov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • metal ions
  • metal binding proteins
  • regulation
  • enzymes
  • structure
  • function

Published Papers

This special issue is now open for submission.
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