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Open AccessArticle

Polyphenol Extract from Evening Primrose (Oenothera paradoxa) Inhibits Invasion Properties of Human Malignant Pleural Mesothelioma Cells

1
Department of Structural Biology, Medical University of Lodz, Zeligowskiego 7/9 Str., 90-752 Lodz, Poland
2
Department of Molecular Cell Mechanisms, Medical University of Lodz, Mazowiecka 6/8 Str., 92-215 Lodz, Poland
3
Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Tuwima 10 Str., 10-748 Olsztyn, Poland
4
Laboratory of Cellular Immunology, Institute of Medical Biology PAS, 106 Lodowa St., 93-232 Lodz, Poland
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(11), 1574; https://doi.org/10.3390/biom10111574
Received: 16 October 2020 / Revised: 10 November 2020 / Accepted: 18 November 2020 / Published: 19 November 2020
(This article belongs to the Section Natural and Bio-inspired Molecules)
Extracts from the defatted evening primrose (Oenothera paradoxa Hudziok) seeds are the source of a range of stable polyphenolic compounds, including ellagic acid, gallic acid, and catechin. Our studies evaluate, for the first time, the influence of evening primrose isopropanol extract (EPE) on malignant pleural mesothelioma (MPM) cells. MPM is rarely diagnosed, its high aggressiveness and frequently noted chemoresistance limit its treatment schemes and it is characterized by low prognostic features. Here, we demonstrate that EPE inhibited MPM growth in a dose-dependent manner in cells with increased invasion properties. Moreover, EPE treatment resulted in cell cycle arrest in the G2/M phase and increased apoptosis in invasive MPM cell lines. Additionally, EPE strongly limited invasion and MMP-7 secretion in MPM cancer cells. Our original data provide evidence about the potential anti-invasive effects of EPE in MPM therapy treatment. View Full-Text
Keywords: malignant pleural mesothelioma; evening primrose extract; Oenothera paradoxa Hudziok extract; polyphenols; cytotoxicity; invasion malignant pleural mesothelioma; evening primrose extract; Oenothera paradoxa Hudziok extract; polyphenols; cytotoxicity; invasion
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MDPI and ACS Style

Chmielewska-Kassassir, M.; Sobierajska, K.; Ciszewski, W.M.; Bukowiecka-Matusiak, M.; Szczesna, D.; Burzynska-Pedziwiatr, I.; Wiczkowski, W.; Wagner, W.; Wozniak, L.A. Polyphenol Extract from Evening Primrose (Oenothera paradoxa) Inhibits Invasion Properties of Human Malignant Pleural Mesothelioma Cells. Biomolecules 2020, 10, 1574. https://doi.org/10.3390/biom10111574

AMA Style

Chmielewska-Kassassir M, Sobierajska K, Ciszewski WM, Bukowiecka-Matusiak M, Szczesna D, Burzynska-Pedziwiatr I, Wiczkowski W, Wagner W, Wozniak LA. Polyphenol Extract from Evening Primrose (Oenothera paradoxa) Inhibits Invasion Properties of Human Malignant Pleural Mesothelioma Cells. Biomolecules. 2020; 10(11):1574. https://doi.org/10.3390/biom10111574

Chicago/Turabian Style

Chmielewska-Kassassir, Malgorzata; Sobierajska, Katarzyna; Ciszewski, Wojciech M.; Bukowiecka-Matusiak, Malgorzata; Szczesna, Dorota; Burzynska-Pedziwiatr, Izabela; Wiczkowski, Wieslaw; Wagner, Waldemar; Wozniak, Lucyna A. 2020. "Polyphenol Extract from Evening Primrose (Oenothera paradoxa) Inhibits Invasion Properties of Human Malignant Pleural Mesothelioma Cells" Biomolecules 10, no. 11: 1574. https://doi.org/10.3390/biom10111574

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