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Biomolecules, Volume 10, Issue 12

December 2020 - 112 articles

Cover Story: Cannabinoid receptor interacting protein 1a (CRIP1a) can (left to right): attenuate CB1 receptor-mediated inhibition of adenylyl cyclase, alter the activated Gi subtype, and reduce beta-arrestin binding to the CB1 receptor. CRIP1a expression thereby increases intracellular cAMP production but decreases CB1 receptor internalization and ERK phosphorylation. This suggests that CRIP1a can regulate physiology in healthy tissues, and that genetic or epigenetic changes can be associated with disease states. Physiological and pathophysiological implications of CRIP1a expression have been reported in embryonic development, seizures, schizophrenia, visual and auditory sensory systems, and cancer. View this paper
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Articles (112)

  • Editorial
  • Open Access
8 Citations
3,256 Views
3 Pages

Bioactive Lipids in Health and Disease

  • Monica Bari,
  • Tiziana Bisogno and
  • Natalia Battista

21 December 2020

Although the primordial concept of lipids is associated with the role they play as key components of the cell membrane, growing research in the field of bioactive lipids and lipidomic technologies proves the prominent role of these molecules in other...

  • Article
  • Open Access
5 Citations
3,342 Views
14 Pages

21 December 2020

Our study aims to investigate the impact of the Maturity-onset diabetes of the young 3 disease-linked rSNP rs35126805 located in the HNF-1α gene promotor on the binding of the transcription factor HNF-4α and consequently on the regulation...

  • Review
  • Open Access
163 Citations
43,059 Views
32 Pages

The Regulation of Fat Metabolism during Aerobic Exercise

  • Antonella Muscella,
  • Erika Stefàno,
  • Paola Lunetti,
  • Loredana Capobianco and
  • Santo Marsigliante

21 December 2020

Since the lipid profile is altered by physical activity, the study of lipid metabolism is a remarkable element in understanding if and how physical activity affects the health of both professional athletes and sedentary subjects. Although not fully d...

  • Review
  • Open Access
28 Citations
7,613 Views
18 Pages

21 December 2020

In biomedical research, there is an ongoing demand for new technologies to elucidate disease mechanisms and develop novel therapeutics. This requires comprehensive understanding of cellular processes and their pathophysiology based on reliable inform...

  • Feature Paper
  • Review
  • Open Access
129 Citations
15,997 Views
64 Pages

Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants

  • Clémence Rives,
  • Anne Fougerat,
  • Sandrine Ellero-Simatos,
  • Nicolas Loiseau,
  • Hervé Guillou,
  • Laurence Gamet-Payrastre and
  • Walter Wahli

21 December 2020

Non-alcoholic fatty liver disease (NAFLD) is often the hepatic expression of metabolic syndrome and its comorbidities that comprise, among others, obesity and insulin-resistance. NAFLD involves a large spectrum of clinical conditions. These range fro...

  • Article
  • Open Access
9 Citations
5,548 Views
12 Pages

Measurement of Serum Testosterone in Nondiabetic Young Obese Men: Comparison of Direct Immunoassay to Liquid Chromatography-Tandem Mass Spectrometry

  • Ana Martínez-Escribano,
  • Julia Maroto-García,
  • Maximiliano Ruiz-Galdón,
  • Rocío Barrios-Rodríguez,
  • Juan J. Álvarez-Millán,
  • Pablo Cabezas-Sánchez,
  • Isaac Plaza-Andrades,
  • María Molina-Vega,
  • Francisco J. Tinahones and
  • María Isabel Queipo-Ortuño
  • + 1 author

19 December 2020

Hypoandrogenemia, a frequent finding in men with obesity, is defined by low concentrations of serum testosterone. Although immunoassay (IA) is the most used method for the determination of this steroid in clinical practice, liquid chromatography-mass...

  • Article
  • Open Access
14 Citations
4,068 Views
26 Pages

18 December 2020

It is estimated that over 1.5 billion people suffer from various forms of chronic liver disease worldwide. The emerging prevalence of metabolic syndromes and alcohol misuse, along with the lack of disease-modifying agents for the therapy of many seve...

  • Article
  • Open Access
69 Citations
7,402 Views
27 Pages

Role of Ferrous Sulfate (FeSO4) in Resistance to Cadmium Stress in Two Rice (Oryza sativa L.) Genotypes

  • Javaria Afzal,
  • Muhammad Hamzah Saleem,
  • Fatima Batool,
  • Ali Mohamed Elyamine,
  • Muhammad Shoaib Rana,
  • Asma Shaheen,
  • Mohamed A. El-Esawi,
  • Muhammad Tariq Javed,
  • Qasim Ali and
  • Muhammad Arslan Ashraf
  • + 2 authors

18 December 2020

The impact of heavy metal, i.e., cadmium (Cd), on the growth, photosynthetic pigments, gas exchange characteristics, oxidative stress biomarkers, and antioxidants machinery (enzymatic and non-enzymatic antioxidants), ions uptake, organic acids exudat...

  • Review
  • Open Access
15 Citations
4,609 Views
23 Pages

Yersinia Outer Membrane Vesicles as Potential Vaccine Candidates in Protecting against Plague

  • Andrey A. Byvalov,
  • Ilya V. Konyshev,
  • Vladimir N. Uversky,
  • Svetlana V. Dentovskaya and
  • Andrey P. Anisimov

18 December 2020

Despite the relatively low incidence of plague, its etiological agent, Yersinia pestis, is an exceptional epidemic danger due to the high infectivity and mortality of this infectious disease. Reports on the isolation of drug-resistant Y. pestis strai...

  • Review
  • Open Access
27 Citations
5,207 Views
24 Pages

Nanobodies as Versatile Tool for Multiscale Imaging Modalities

  • Marco Erreni,
  • Tilo Schorn,
  • Francesca D’Autilia and
  • Andrea Doni

18 December 2020

Molecular imaging is constantly growing in different areas of preclinical biomedical research. Several imaging methods have been developed and are continuously updated for both in vivo and in vitro applications, in order to increase the information a...

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Biomolecules - ISSN 2218-273X