Regulating Proteasome Activity

Dear Colleagues,

Strictly controlled degradation of the proteome is a key factor in maintaining cellular homeostasis and allows for a rapid and effective response to stress challenges of different nature. The central element of the regulatory degradative network that integrates different stimuli and signals is the proteasome, a macromolecular machine designed to selectively remove specific proteins according to the variable needs of the cell. Not surprisingly, given the extreme complexity and interdependence of the pathways involved, the proteolytic system has evolved with a modular organization, based on a central hydrolytic element, Proteasome 20S, to which alternative regulatory modules can associate to fine-tune its activity. The perturbation of this delicate network is involved in the onset of various pathological conditions, and in recent years, the strategies for modulating this proteolytic pathway have proven to be extremely useful for both research and therapeutic purposes.

This Special Issue will focus on all aspects of the properties and regulations of proteasomes, including functions and mechanisms of action of physiological proteasome interactors, as well as pharmacological molecules that activate or inhibit its enzymatic activities. Original research articles and reviews summarizing recent crucial advances in the field are welcome.

Prof. Dr. Paolo Cascio
Prof. Dr. Gunnar Dittmar
Guest Editors

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