Table of Contents
Biomolecules, Volume 10, Issue 10 (October 2020) – 115 articles
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Cover Story (view full-size image) Glycans present extraordinary structural diversity commensurate with their involvement in numerous [...] Read more. Glycans present extraordinary structural diversity commensurate with their involvement in numerous fundamental cellular processes. Unfortunately, software packages to mine useful information from mass spectrometry data for glycomic analysis are scarce, which prevents expansion of the field. To overcome this problem, we developed the novel Toolbox Accelerating Glycomics (TAG) program. TAG automatically annotates and quantifies the glycan signals on MALDI-TOF MS spectra and visualizes variation in glycan expression based on glycan biosynthetic pathways. In this article, we discuss the concepts, outline the TAG process, and demonstrate its potential using glycomic expression profile data from Chinese hamster ovary cells and mutants lacking a functional Npc1 gene. View this paper