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Journal of Clinical Medicine, Volume 14, Issue 13

July-1 2025 - 424 articles

Cover Story: Venous thromboembolism (VTE) is a major source of preventable morbidity in neurocritically ill patients, yet the optimal timing and agent for pharmacologic thromboprophylaxis (PTP) remain uncertain. In this review of 90 studies, including 669,725 patients with traumatic brain injury, intracerebral hemorrhage, subarachnoid hemorrhage, or spinal cord injury, or those requiring neurosurgical intervention, early PTP (within 24–72 hours) was generally associated with reduced VTE risk without a consistently increased risk of bleeding. Enoxaparin showed potential benefits over unfractionated heparin in certain subgroups. Safety may be improved in some injury types, with early repeat imaging suggesting stable bleeding. Despite variability in study designs and quality, this updated assessment of the literature supports early, individualized PTP strategies. View this paper
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Articles (424)

  • Article
  • Open Access
1,866 Views
13 Pages

A Novel Approach to the Study of Pathophysiology in Patients with Obstructive Sleep Apnea Using the Iowa Oral Performance Instrument (IOPI)

  • Andrés Navarro,
  • Gabriela Bosco,
  • Bárbara Serrano,
  • Peter Baptista,
  • Carlos O’Connor-Reina and
  • Guillermo Plaza

7 July 2025

Background: Myofunctional therapy has emerged as a treatment option for obstructive sleep apnea (OSA). The Iowa Oral Performance Instrument (IOPI) enables objective measurement of lingual and orofacial muscle strength, although it was originally desi...

  • Article
  • Open Access
2 Citations
2,429 Views
12 Pages

Systemic Biologic Treatment for Psoriasis in Elderly Patients

  • Sapir Glazer Levavi,
  • Ronny Maman,
  • Shany Sherman,
  • Daniel Mimouni and
  • Lev Pavlovsky

7 July 2025

Approximately 3–13% of patients with psoriasis are first affected after age 60 years. Numerous studies have investigated the use of biologic agents for the treatment of psoriasis, but the routine exclusion of elderly adults from clinical trials...

  • Article
  • Open Access
2,290 Views
17 Pages

7 July 2025

Introduction: Social prescribing is an innovative approach that connects individuals to community-based activities to promote well-being. This study explores the barriers and facilitators influencing older adults’ engagement in social prescribi...

  • Article
  • Open Access
995 Views
12 Pages

Assessment of Bronchodilator Response in Patients with CF and Non-CF Bronchiectasis—A Randomized Controlled Study

  • Mordechai Pollak,
  • Ronen Bar-Yoseph,
  • Moneera Hanna,
  • Noa Serruya,
  • Guy Gut,
  • Lea Bentur and
  • Michal Gur

7 July 2025

Objectives: Although patients with bronchiectasis tend to have obstructive nonreversible lung functions, some have bronchodilator response (BDR), and a relatively large number are treated with bronchodilators. We assessed BDR in patients with cystic...

  • Article
  • Open Access
691 Views
9 Pages

Characterisation of Ventricular Nucleotide Metabolism and Clinical Predictors Associated with the Onset of Atrial Fibrillation Following Cardiac Surgery

  • Daniel Paul Fudulu,
  • Arnaldo Dimagli,
  • Marco Moscarelli,
  • Rahul Kota,
  • Tim Dong,
  • Marco Gemelli,
  • Manraj Sandhu,
  • Saadeh Suleiman and
  • Gianni D. Angelini

7 July 2025

Introduction: Postoperative atrial fibrillation (POAF) is a common complication after heart surgery, adversely impacting clinical outcomes and healthcare costs. Little is known about the dynamics of nucleotide metabolism associated with the developme...

  • Review
  • Open Access
3 Citations
6,512 Views
28 Pages

The Complex Relationship Between Heart Failure and Chronic Obstructive Pulmonary Disease: A Comprehensive Review

  • Luiza Elena Corneanu,
  • Mara Sînziana Sîngeap,
  • Victoria Mutruc,
  • Ovidiu Rusalim Petriș,
  • Tudor P. Toma,
  • Victorița Șorodoc,
  • Laurențiu Șorodoc and
  • Cătălina Lionte

6 July 2025

The coexistence of heart failure (HF) and chronic obstructive pulmonary disease (COPD) presents a significant clinical challenge due to the common risk factors, overlapping symptoms, and complex pathophysiological interactions and mechanisms. This co...

  • Review
  • Open Access
1 Citations
1,526 Views
19 Pages

DSC Perfusion MRI Artefact Reduction Strategies: A Short Overview for Clinicians and Scientific Applications

  • Chris W. J. van der Weijden,
  • Ingomar W. Gutmann,
  • Joost F. Somsen,
  • Gert Luurtsema,
  • Tim van der Goot,
  • Fatemeh Arzanforoosh,
  • Miranda C. A. Kramer,
  • Anne M. Buunk,
  • Erik F. J. de Vries and
  • Alexander Rauscher
  • + 1 author

6 July 2025

MRI perfusion is used to diagnose and monitor neurological conditions such as brain tumors, stroke, dementia, and traumatic brain injury. Dynamic Susceptibility Contrast (DSC) is the most widely available quantitative MRI technique for perfusion imag...

  • Article
  • Open Access
1,189 Views
15 Pages

Spatial Distribution and Post-COVID-19 Health Complications in Older People: A Brazilian Cohort Study

  • Franciele Aline Machado de Brito,
  • Carlos Laranjeira,
  • Stéfane Lele Rossoni,
  • Amira Mohammed Ali,
  • Maria Aparecida Salci and
  • Lígia Carreira

6 July 2025

Background/Objectives: In the aftermath of the COVID-19 pandemic, individuals infected with SARS-CoV-2 have progressively displayed a range of symptoms linked to protracted COVID during the post-acute phase of illness. Concurrently, in several nation...

  • Systematic Review
  • Open Access
1 Citations
5,119 Views
16 Pages

Review of the Safety and Clinical Considerations of Vasoconstrictor Agents in Dental Anesthesia During Pregnancy

  • Andrei Urîtu,
  • Victor Bogdan Buciu,
  • Ciprian Roi,
  • Doina Chioran,
  • Denis Mihai Serban,
  • Nicolae Nicoleta,
  • Elena Lavinia Rusu,
  • Mihai Ionac,
  • Mircea Riviș and
  • Sebastian Ciurescu

6 July 2025

Background: The use of vasoconstrictors in dental anesthesia during pregnancy raises clinical concerns due to their potential effects on uteroplacental blood flow and fetal well-being. Despite widespread use, the safety profiles of agents such as epi...

  • Article
  • Open Access
1,054 Views
14 Pages

Exploring Intensity-Dependent Echogenic Response to Percutaneous Electrolysis in Tendon Tissue: A Cadaveric Study

  • Miguel Malo-Urriés,
  • Jacobo Rodríguez-Sanz,
  • Sergio Borrella-Andrés,
  • Isabel Albarova-Corral,
  • Juan Carlos Martínez-Zamorano and
  • Carlos López-de-Celis

6 July 2025

Background: Percutaneous electrolysis (PE) is an emerging therapeutic approach for tendinopathies, applying a galvanic current through a dry-needling needle to induce regenerative tissue responses. However, current dosing strategies are often empiric...

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J. Clin. Med. - ISSN 2077-0383