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Review

The Role of C-Reactive Protein in Acute Myocardial Infarction: Unmasking Diagnostic, Prognostic, and Therapeutic Insights

by
Andreas Mitsis
1,*,
Stefanos Sokratous
1,
Georgia Karmioti
1,
Michaela Kyriakou
1,
Michail Drakomathioulakis
1,
Michael M. Myrianthefs
1,
Christos Eftychiou
1,
Nikolaos P. E. Kadoglou
2,
Stergios Tzikas
3,
Nikolaos Fragakis
4 and
George Kassimis
4
1
Cardiology Department, State Health Services Organization, Nicosia General Hospital, 215 Old Road Nicosia-Limassol, Nicosia 2029, Cyprus
2
Medical School, University of Cyprus, Nicosia 2115, Cyprus
3
Third Department of Cardiology, Aristotle University of Thessaloniki, 54626 Thessaloniki, Greece
4
Second Department of Cardiology, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2025, 14(13), 4795; https://doi.org/10.3390/jcm14134795
Submission received: 27 May 2025 / Revised: 25 June 2025 / Accepted: 4 July 2025 / Published: 7 July 2025
(This article belongs to the Special Issue Acute Coronary Syndromes: From Diagnosis to Treatment)
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Abstract

C-reactive protein (CRP) has emerged as a valuable biomarker in acute myocardial infarction (AMI), offering multiple insights into diagnosis, prognosis, and therapeutic strategies. In the diagnostic domain, elevated CRP levels serve as an early indicator of AMI, aiding in prompt identification and initiation of treatment. Prognostically, CRP is a strong predictor of adverse outcomes post-AMI, correlating with increased mortality and cardiovascular events. Beyond its diagnostic and prognostic roles, CRP also exposes therapeutic avenues in AMI management. Targeting CRP through pharmacological interventions has shown promise in reducing inflammatory responses, thereby mitigating myocardial damage and improving clinical outcomes. However, CRP’s low specificity, influenced by elevation in non-cardiac conditions, remains a clinical limitation that warrants consideration. This review comprehensively examines the evolving role of CRP in AMI, exploring its diagnostic accuracy, prognostic significance, and potential as a therapeutic target. The understanding of the complex role of CRP in AMI provides clinicians with valuable tools for risk stratification, treatment optimization, and personalized patient care in the acute setting.
Keywords: C-reactive protein; acute myocardial infarction; inflammation; biomarkers; cardiovascular risk; prognosis; diagnosis; immune response C-reactive protein; acute myocardial infarction; inflammation; biomarkers; cardiovascular risk; prognosis; diagnosis; immune response

Share and Cite

MDPI and ACS Style

Mitsis, A.; Sokratous, S.; Karmioti, G.; Kyriakou, M.; Drakomathioulakis, M.; Myrianthefs, M.M.; Eftychiou, C.; Kadoglou, N.P.E.; Tzikas, S.; Fragakis, N.; et al. The Role of C-Reactive Protein in Acute Myocardial Infarction: Unmasking Diagnostic, Prognostic, and Therapeutic Insights. J. Clin. Med. 2025, 14, 4795. https://doi.org/10.3390/jcm14134795

AMA Style

Mitsis A, Sokratous S, Karmioti G, Kyriakou M, Drakomathioulakis M, Myrianthefs MM, Eftychiou C, Kadoglou NPE, Tzikas S, Fragakis N, et al. The Role of C-Reactive Protein in Acute Myocardial Infarction: Unmasking Diagnostic, Prognostic, and Therapeutic Insights. Journal of Clinical Medicine. 2025; 14(13):4795. https://doi.org/10.3390/jcm14134795

Chicago/Turabian Style

Mitsis, Andreas, Stefanos Sokratous, Georgia Karmioti, Michaela Kyriakou, Michail Drakomathioulakis, Michael M. Myrianthefs, Christos Eftychiou, Nikolaos P. E. Kadoglou, Stergios Tzikas, Nikolaos Fragakis, and et al. 2025. "The Role of C-Reactive Protein in Acute Myocardial Infarction: Unmasking Diagnostic, Prognostic, and Therapeutic Insights" Journal of Clinical Medicine 14, no. 13: 4795. https://doi.org/10.3390/jcm14134795

APA Style

Mitsis, A., Sokratous, S., Karmioti, G., Kyriakou, M., Drakomathioulakis, M., Myrianthefs, M. M., Eftychiou, C., Kadoglou, N. P. E., Tzikas, S., Fragakis, N., & Kassimis, G. (2025). The Role of C-Reactive Protein in Acute Myocardial Infarction: Unmasking Diagnostic, Prognostic, and Therapeutic Insights. Journal of Clinical Medicine, 14(13), 4795. https://doi.org/10.3390/jcm14134795

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