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Lung Transplantation: Current Strategies and Future Directions

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Respiratory Medicine".

Deadline for manuscript submissions: 28 December 2025 | Viewed by 422

Special Issue Editors


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Guest Editor
Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland
Interests: lung transplantation; lung volume reduction; pulmonary endarterectomy; lung cancer; organ preservation; LVRS; pulmonary endarterectomy

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Guest Editor
Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria
Interests: lung transplantation; bridge to lung transplantation; ECMO/ECLS; complex tracheobronchial procedures; septic chest surgery; endobronchial stenting; laser surgery

Special Issue Information

Dear Colleagues,

Lung transplantation remains a critical therapeutic option for patients with end-stage pulmonary disease, yet it is challenged by issues such as donor organ shortage, rejection, and long-term graft survival. This Special Issue, entitled "Lung Transplantation: Current Strategies and Future Directions", aims to explore the latest advancements and ongoing challenges in this field. This Special Issue seeks to highlight innovative approaches to donor lung preservation, optimization of immunosuppressive regimens, and management of chronic lung allograft dysfunction. Moreover, we aim to delve into emerging strategies, such as xenotransplantation, graft optimization, and artificial lung, that hold the potential to transform lung transplantation outcomes.

The scope of this Special Issue covers clinical and translational research, focusing on enhancing both short-term and long-term success rates in lung transplantation. By bringing together cutting-edge research and expert perspectives, this Special Issue aims to address the core problems limiting lung transplantation efficacy and mobilize the scientific community toward innovative solutions that could redefine the future of this life-saving procedure.

In this Special Issue, original research articles and reviews are welcome to be submitted.

We look forward to receiving your contributions.

Dr. Omer Senbaklavaci
Dr. György Lang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lung transplantation
  • graft optimization
  • immunosuppression
  • artificial lung
  • xenotransplantation
  • end-stage lung disease
  • donor lung preservation
  • chronic lung allograft dysfunction

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Published Papers (1 paper)

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Research

14 pages, 566 KiB  
Article
Impact of RSV Infection in Transplant and Immunocompromised Population: Incidence and Co-Infections: Retrospective Analysis of a Single Centre
by Paolo Solidoro, Antonio Curtoni, Sara Minuto, Nour Shbaklo, Francesco Giuseppe De Rosa, Alessandro Bondi, Francesca Sidoti, Filippo Patrucco, Elisa Zanotto, Silvia Corcione, Massimo Boffini, Matteo Marro, Cristina Costa and Rocco Francesco Rinaldo
J. Clin. Med. 2025, 14(13), 4803; https://doi.org/10.3390/jcm14134803 - 7 Jul 2025
Viewed by 156
Abstract
Respiratory syncytial virus (RSV) represents one of the main respiratory infections found among immunocompromised patients. Objective: The study analyzes the incidence of RSV infection in different populations of immunocompromised patients as organ transplant recipients (lung, other solid organs, hematopoietic stem cells) and [...] Read more.
Respiratory syncytial virus (RSV) represents one of the main respiratory infections found among immunocompromised patients. Objective: The study analyzes the incidence of RSV infection in different populations of immunocompromised patients as organ transplant recipients (lung, other solid organs, hematopoietic stem cells) and oncologic patients (solid organ malignancy and hematological malignancy) compared to a group of non-immunocompromised patients. We also assessed the prevalence of viral, bacterial, and mycotic coinfection. Moreover, we aimed at evaluating the efficacy of ribavirin treatment in terms of mortality reduction. Methods: We conducted a retrospective analysis on a total of 466 transplant patients undergoing bronchoscopy with bronchoalveolar lavage for suspected viral disease or surveillance between 2016 and 2023, compared to 460 controls. Results: The incidence of RSV was significantly higher in immunocompromised patients, particularly in those with lung and bone marrow transplants. Among RSV+ patients, a higher prevalence of viral (influenza virus), bacterial (S. pneumoniae, M. pneumoniae, Nocardia spp.), and fungal (Aspergillus spp.) coinfections were observed. The efficacy of ribavirin in reducing mortality did not show significant differences compared to supportive therapy alone. Conclusions: The results of our exploratory study suggest that immunocompromised patients are particularly vulnerable to RSV infection and coinfections. Our hypothesis-generating data warrant the need for future studies aimed at exploring preventive and therapeutic strategies for RSV infection in these high-risk patient groups. Full article
(This article belongs to the Special Issue Lung Transplantation: Current Strategies and Future Directions)
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