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Brain Sci., Volume 10, Issue 2 (February 2020) – 70 articles
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Cover Story (view full-size image) Lemur tyrosine-kinase 2 (LMTK2) is implicated in several physiological and pathological processes. [...] Read more. Lemur tyrosine-kinase 2 (LMTK2) is implicated in several physiological and pathological processes. Recent studies have found decreased LMTK2 level in Alzheimer’s disease (AD). However, the relation between LMTK2 and neurofibrillary tangles (NFTs) as the hallmark pathological alteration of AD has not yet been investigated. The main constituent of NFTs is the hyperphosphorylated tau protein. Therefore, we performed LMTK2/phospho-tau fluorescent double-labelling immunohistochemistry in different neuropathological Braak tau stages of AD. We detected a strong negative correlation between the expression of LMTK2 and the extent of NFT pathology. Consequently, it seems that decreased LMTK2 level is not a general feature of AD brains; rather, it is characteristic of the NFT‐affected regions. View this paper