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Open AccessArticle

Traumatic Brain Injury Patients Mortality and Serum Total Antioxidant Capacity

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Intensive Care Unit, Hospital Universitario de Canarias, 38320 Ofra s/n. La Laguna, Spain
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Intensive Care Unit, Hospital Universitario Nuestra Señora de Candelaria, 38020 Crta del Rosario s/n., Spain
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Laboratory Department, Hospital Universitario de Canarias, 38320 Ofra s/n. La Laguna, Spain
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Department of Physiology, Faculty of Medicine, University of the La Laguna, 38320 Ofra s/n. La Laguna, Spain
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Intensive Care Unit, Hospital General La Palma, 38713 Buenavista de Arriba s/n., Spain
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Intensive Care Unit, Hospital Clínico Universitario de Valencia, Avda, Blasco Ibáñez nº17-19, 46004 Valencia, Spain
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Intensive Care Unit, Hospital Universitario Dr. Negrín, CIBERES, 35010 Barranco de la Ballena s/n. Las Palmas de Gran Canaria, Spain
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Intensive Care Unit, Hospital Insular. Plaza Dr. Pasteur, 35016 s/n. Las Palmas de Gran Canaria, Spain
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Research Unit, Hospital Universitario de Canarias, 38320 Ofra s/n. La Laguna, Spain
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Department of Neurosurgery, Hospital Universitario de Canarias, 38320 Ofra s/n. La Laguna, Spain
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Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(2), 110; https://doi.org/10.3390/brainsci10020110
Received: 22 December 2019 / Revised: 29 January 2020 / Accepted: 15 February 2020 / Published: 18 February 2020
Objective: Oxidation is involved in secondary brain injury after traumatic brain injury (TBI). Increased concentrations of total antioxidant capacity (TAC) in blood at the time of admission for TBI have been found in non-surviving patients. The main objective of this study was to determine the role of serum TAC levels at any time during the first week of TBI for the prediction of early mortality. Methods: Isolated (<10 points in non-cranial aspects of Injury Severity Score) and severe (<9 points in Glasgow Coma Scale) TBI patients were included. Serum TAC concentrations at days 1, 4, and 8 of TBI were determined. The end-point study was 30-day mortality. Results: Higher serum TAC levels at days 1 (p < 0.001), 4 (p < 0.001), and 8 (p = 0.002) of TBI were found in non-surviving (n = 34) than in surviving patients (n = 90). The area under curve (95% Confidence Interval) for prediction of 30-day mortality by serum TAC concentrations at days 1, 4, and 8 of TBI were 0.79 (0.71–0.86; p < 0.001), 0.87 (0.79–0.93; p < 0.001), and 0.76 (0.67–0.84; p = 0.006) respectively. Conclusions: The novelty of our study was the ability to predict 30-day mortality by serum TAC concentrations at any time during the first week of TBI. View Full-Text
Keywords: total antioxidant capacity; traumatic brain injury; patients; mortality; prognosis total antioxidant capacity; traumatic brain injury; patients; mortality; prognosis
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Lorente, L.; Martín, M.M.; Pérez-Cejas, A.; González-Rivero, A.F.; Abreu-González, P.; Ramos, L.; Argueso, M.; Solé-Violán, J.; Cáceres, J.J.; Jiménez, A.; García-Marín, V. Traumatic Brain Injury Patients Mortality and Serum Total Antioxidant Capacity. Brain Sci. 2020, 10, 110.

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