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Open AccessEditorial

ABCA7—A Member of the ABC Transporter Family in Healthy and Ailing Brain

1
Department of Surgery, Section of Otolaryngology, Yale School of Medicine, Yale University, New Haven, CT 06510, USA
2
Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(2), 121; https://doi.org/10.3390/brainsci10020121
Received: 19 February 2020 / Accepted: 21 February 2020 / Published: 22 February 2020
Identification of genetic markers of a human disease, which is generally sporadic, may become an essential tool for the investigation of its molecular mechanisms. The role of ABCA7 in Alzheimer’s disease (AD) was discovered less than ten years ago when meta-analyses provided evidence that rs3764650 is a new AD susceptibility locus. Recent research advances in this locus and new evidence regarding ABCA7 contribution to the AD pathogenesis brought a new understanding of the underlying mechanisms of this disorder. An interesting, up-to-date review article "ABCA7 and Pathogenic Pathways of Alzheimer’s Disease" by Aikawa et al. (2018), outlines the ABCA7 role in AD and summarizes new findings in this exciting area. ABC transporters or ATP-binding cassette transporters are a superfamily of proteins belonging to a cell transport system. Currently, members of the family are the focus of attention because of their central role in drug pharmacokinetics. Two recent findings are the reason why much attention is drawn to the ABCA7 family. First, is the biochemical data showing a role of ABCA7 in amyloid pathology. Second, genetic data identifying ABCA7 gene variants as loci responsible for the late-onset AD. These results point to the ABCA7 as a significant new contributor to the pathogenesis of AD. View Full-Text
Keywords: Alzheimer’s disease; ATP-binding cassette; ABCA7; amyloid-β; amyloid precursor protein; presenilin Alzheimer’s disease; ATP-binding cassette; ABCA7; amyloid-β; amyloid precursor protein; presenilin
MDPI and ACS Style

Surguchev, A.A.; Surguchov, A. ABCA7—A Member of the ABC Transporter Family in Healthy and Ailing Brain. Brain Sci. 2020, 10, 121.

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