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Brain Sci., Volume 10, Issue 1 (January 2020) – 57 articles
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Cover Story (view full-size image) Glioblastoma (GB) are a grade IV aggressive brain tumor with limited treatment options available [...] Read more. Glioblastoma (GB) are a grade IV aggressive brain tumor with limited treatment options available (chemo- and radiation therapy). The usual lifespan of patients is about 18 months following treatment. To extend the quality of life beyond this boundary, better approaches are necessary, such as targeted gene and drug therapy, use of oncolytic virus, and nutraceuticals. Some of these treatments can reach the GB brain, crossing the blood–brain barrier following systemic injections; however, most of them are failing. To overcome this issue, we and others have used nanoparticles as a vehicle to deliver therapeutics to the brain following systemic injections. View this paper