Special Issue "Molecular and Cellular Mechanisms Mediating the Behavioral Effects of Alcohol"
Deadline for manuscript submissions: closed (31 August 2020) | Viewed by 17909
Alcoholic beverages are commonly consumed for the positively reinforcing properties of their molecular constituent, ethanol. At different doses, ethanol can produce a variety of behavioral effects, ranging from euphoria to anxiolysis, appetite stimulation, cognitive and motor alterations, aggression, sedation, and coma. Pathological patterns of alcohol consumption can alter the initial response to ethanol, and additional behavioral changes emerge during acute withdrawal and protracted abstinence from alcohol (e.g., seizures, craving, negative affect). Alcohol exposure during adolescence, gestation, and gametogenesis can also have a long-term impact on behaviors later in life and across generations, as a result of developmental and epigenetic effects. Identifying the stuctural and functional changes in specific brain regions, cell populations, or neural circuits which causally contribute to the behavioral phenotypes associated with ethanol exposure and withdrawal is essential to our understanding of the neurobiological mechanisms underlying alcohol’s action. It also represents a critical endeavor for the development of rational approaches to leverage the desirable properties of ethanol and to alleviate the burden associated with the detrimental consequences of excessive alcohol consumpion.
Original research articles advancing our understanding of the “Molecular and Cellular Mechanisms Mediating the Behavioral Effects of Ethanol” are solicited for this Special Issue. Reviews providing an analytical perspective on the existing literature are also welcome.
Dr. Candice Contet
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- binge drinking
- alcohol use disorders
- signaling pathways
- medication development