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Open AccessArticle

Lemur Tyrosine Kinase 2 (LMTK2) Level Inversely Correlates with Phospho-Tau in Neuropathological Stages of Alzheimer’s Disease

1
Department of Pathology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary
2
MTA-DE Cerebrovascular and Neurodegenerative Research Group, Department of Neurology, University of Debrecen, 4032 Debrecen, Hungary
3
Horvath Csaba Memorial Institute of Bioanalytical Research, Research Centre for Molecular Medicine, University of Debrecen, 4032 Debrecen, Hungary
4
Vitrolink Ltd., 4033 Debrecen, Hungary
5
Institute for Nuclear Research of the Hungarian Academy of Sciences (ATOMKI), 4026 Debrecen, Hungary
6
Institute of Pathology, Faculty of Medicine, University of Szeged, 6725 Szeged, Hungary
7
Department of Old Age Psychiatry, Institute of Psychiatry Psychology and Neuroscience, King’s College London, London, SE5 8AF, UK
8
Centre for Age-Related Medicine, SESAM, Stavanger University Hospital, 4011 Stavanger, Norway
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(2), 68; https://doi.org/10.3390/brainsci10020068
Received: 20 December 2019 / Revised: 17 January 2020 / Accepted: 25 January 2020 / Published: 27 January 2020
(This article belongs to the Collection Collection on Molecular and Cellular Neuroscience)
: Alzheimer’s disease (AD) is the most common neurodegenerative dementia. Mapping the pathomechanism and providing novel therapeutic options have paramount significance. Recent studies have proposed the role of LMTK2 in AD. However, its expression pattern and association with the pathognomonic neurofibrillary tangles (NFTs) in different brain regions and neuropathological stages of AD is not clear. We performed chromogenic (CHR) LMTK2 and fluorescent phospho-tau/LMTK2 double-labelling (FDL) immunohistochemistry (IHC) on 10–10 postmortem middle frontal gyrus (MFG) and anterior hippocampus (aHPC) samples with early and late neuropathological Braak tau stages of AD. MFG in early stage was our ‘endogenous control’ region as it is not affected by NFTs. Semiquantitative CHR-IHC intensity scoring revealed significantly higher (p < 0.001) LMTK2 values in this group compared to NFT-affected regions. FDL-IHC demonstrated LMTK2 predominance in the endogenous control region, while phospho-tau overburden and decreased LMTK2 immunolabelling were detected in NFT-affected groups (aHPC in early and both regions in late stage). Spearman’s correlation coefficient showed strong negative correlation between phospho-tau/LMTK2 signals within each group. According to our results, LMTK2 expression is inversely proportionate to the extent of NFT pathology, and decreased LMTK2 level is not a general feature in AD brain, rather it is characteristic of the NFT-affected regions.
Keywords: Alzheimer’s disease; LMTK2; neurodegeneration; tau; digital image analysis Alzheimer’s disease; LMTK2; neurodegeneration; tau; digital image analysis
MDPI and ACS Style

Bencze, J.; Szarka, M.; Bencs, V.; Szabó, R.N.; Módis, L.V.; Aarsland, D.; Hortobágyi, T. Lemur Tyrosine Kinase 2 (LMTK2) Level Inversely Correlates with Phospho-Tau in Neuropathological Stages of Alzheimer’s Disease. Brain Sci. 2020, 10, 68.

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