Experimental and Clinical Treatment of Subarachnoid Hemorrhage after Rupture of Saccular Intracranial Aneurysms

Dear Colleagues,

Subarachnoid hemorrhage (SAH) due to intracranial aneurysm rupture is a devastating event leaving mainly young people in their productive life severely disabled. Although SAH accounts for only 5–10% of all strokes, the disease has a significant socioeconomic impact. Every second patient suffers permanent disability and the estimated litetime cost is more than double that of ischemic stroke. The main culprit for the dismal outcome in SAH patients was mainly attributed to delayed cerebral vasospasm, leading to ischemia and cerebral infarction. Clinical attenuation of cerebral vasospasm was finally achieved by successful translation of prior experimental animal work but functional outcomes in patients remained unimproved. These results eroded the hypothesis of cerebral vasospasm as the single main cause of poor outcome after SAH. Early brain injury emerged as a relatively new entity, embracing multiple and complex pathophysiological mechanisms that take place early after SAH. The exact roles of these early pathological phenomenons are just now being elucidated.

The purpose of this Special Issue is to provide an up-to-date overview of the pathophysiology, experimental treatment approaches, and clinical management of subarachnoid hemorrhage. Original, high-quality research papers, as well as review articles addressing the major research challenges and achievements on the topic, are sought. Potential topics include, but are not limited to, the following: Novel pharmacological therapies; translational and clinical studies; biomarkers in SAH; microcirculatory disturbance; early brain injury; delayed cerebral vasospasm; neurobehavioral aspects; prevention of intracranial aneurysm rupture; epidemiological studies; neuroimaging; clinical guidelines; neurointensive care management; and future perspectives in SAH research.

Dr. Serge Marbacher
Prof. Dr. John H. Zhang
Guest Editors

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