Special Issue "Pharmacology and Toxicology of New Psychoactive Substances: Focus on Novel Synthetic Opioids"
A special issue of Brain Sciences (ISSN 2076-3425).
Deadline for manuscript submissions: closed (15 September 2020) | Viewed by 17416
Interests: Liquid Chromatography; Neurobiology; Neurophysiology; Learning and Memory
Special Issues, Collections and Topics in MDPI journals
Novel Psychoactive Substances (NPS) are a broad variety of drugs not regulated by present legislation. The advent of NPS has contributed to the appearance and growth of a new ‘drug scenario’ characterized by an increased number of drug users among youth and the consumption of drugs with unknown effects or safety profiles. Preclinical and clinical findings have shown that at lower doses NPS may produce effects comparable to those of illicit psychoactive drugs, such as cannabis, heroin, cocaine and MDMA, however, with more severe consequences. The first wave of NPS came to Europe in the early 2000s in the form of synthetic cannabinoids followed by synthetic cathinones and phenethylamines. From 2016, a rise in the availability of novel synthetic opioids (NSO) was registered in Europe. NSO are the most dangerous NPS since they mimic morphine and heroin and are many times more potent than these opioids in producing acute toxicity. Moreover, they are effective by the intranasal and oral route. Consequently, their use is likely to become the primary source of NPS-associated deaths in Europe, given their increasing prevalence, as opposed to that of other NPS classes. This Special Issue aims to provide an up-to-date overview of pharmacology, structure–activity relationships, and toxicology of NPS and NSO, and the detrimental effects associated with their intake.
Dr. Maria Antonietta De Luca
Manuscript Submission Information
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- structure–activity relationships