Table of Contents
Microorganisms, Volume 7, Issue 7 (July 2019)
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Cover Story (view full-size image) Shiga toxin-producing Escherichia coli (STEC) strains are associated with human diarrhea, and some [...] Read more. Shiga toxin-producing Escherichia coli (STEC) strains are associated with human diarrhea, and some strains may cause hemolytic–uremic syndrome. The pathogenesis of STEC in intestinal illness usually entails bacterial attachment to the intestinal epithelial cells, microvillus destruction, and Shiga toxin translocation. In this article, a system biology approach was used to investigate the transcriptomic and phenotypic responses of enterocyte-like Caco-2 cells to STEC strains. Serial scanning electron microscopy (SEM) images and temporal dynamic gene co-expression networks (GCN) for Caco-2 cells were obtained during three hours of enterocyte-STEC interaction. SEM showed a bacterial adherence to the cells and a progressive loss of microvilli. GCN analysis revealed network topological variation during enterocyte–STEC interaction. View this paper.