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Open AccessArticle

A Histone Acetyltransferase Inhibitor with Antifungal Activity against CTG clade Candida Species

Max Perutz Labs Vienna, Center for Medical Biochemistry, Medical University of Vienna, Dr. Bohr-Gasse 9/2, A-1030 Vienna, Austria
Authors to whom correspondence should be addressed.
Microorganisms 2019, 7(7), 201;
Received: 2 July 2019 / Revised: 10 July 2019 / Accepted: 12 July 2019 / Published: 15 July 2019
(This article belongs to the Special Issue Molecular Mechanisms of Fungal Virulence and Commensalism)
Candida species represent one of the most frequent causes of hospital-acquired infections in immunocompromised patient cohorts. Due to a very limited set of antifungals available and an increasing prevalence of drug resistance, the discovery of novel antifungal targets is essential. Targeting chromatin modifiers as potential antifungal targets has gained attention recently, mainly due to their role in regulating virulence in Candida species. Here, we describe a novel activity for the histone acetyltransferase inhibitor Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone (CPTH2) as a specific inhibitor of CTG clade Candida species. Furthermore, we show that CPTH2 has fungicidal activity and protects macrophages from Candida-mediated death. Thus, this work could provide a starting point for the development of novel antifungals specific to CTG clade Candida species. View Full-Text
Keywords: Candida; CTG clade; histone acetyltransferase inhibitor Candida; CTG clade; histone acetyltransferase inhibitor
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Tscherner, M.; Kuchler, K. A Histone Acetyltransferase Inhibitor with Antifungal Activity against CTG clade Candida Species. Microorganisms 2019, 7, 201.

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