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The Host-Microbe Interplay in Human Papillomavirus-Induced Carcinogenesis

1
Faculty of Medicine, Kindai University, Osaka-Sayama, Osaka 589-8511, Japan
2
Faculty of Medical technology, Hanoi Medical University, Ton That Tung 1, DongDa, Hanoi 100-000, Vietnam
3
Department of Hematology and Rheumatology, Faculty of Medicine, Kindai University, Osaka-Sayama, Osaka 589-8551, Japan
*
Author to whom correspondence should be addressed.
Microorganisms 2019, 7(7), 199; https://doi.org/10.3390/microorganisms7070199
Received: 12 June 2019 / Revised: 9 July 2019 / Accepted: 11 July 2019 / Published: 13 July 2019
(This article belongs to the Special Issue Updates on Human Papillomavirus Induced Neoplasms)
Every year nearly half a million new cases of cervix cancer are diagnosed worldwide, making this malignancy the fourth commonest cancer in women. In 2018, more than 270,000 women died of cervix cancer globally with 85% of them being from developing countries. The majority of these cancers are caused by the infection with carcinogenic strains of human papillomavirus (HPV), which is also causally implicated in the development of other malignancies, including cancer of the anus, penis cancer and head and neck cancer. HPV is by far the most common sexually transmitted infection worldwide, however, most infected people do not develop cancer and do not even have a persistent infection. The development of highly effective HPV vaccines against most common high-risk HPV strains is a great medical achievement of the 21st century that could prevent up to 90% of cervix cancers. In this article, we review the current understanding of the balanced virus-host interaction that can lead to either virus elimination or the establishment of persistent infection and ultimately malignant transformation. We also highlight the influence of certain factors inherent to the host, including the immune status, genetic variants and the coexistence of other microbe infections and microbiome composition in the dynamic of HPV infection induced carcinogenesis. View Full-Text
Keywords: human papilloma virus; virus induced carcinogenesis; immunosurveillance; genetic variation; human microbiome human papilloma virus; virus induced carcinogenesis; immunosurveillance; genetic variation; human microbiome
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Wakabayashi, R.; Nakahama, Y.; Nguyen, V.; Espinoza, J.L. The Host-Microbe Interplay in Human Papillomavirus-Induced Carcinogenesis. Microorganisms 2019, 7, 199.

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