Virulence Identification and Analysis from Pathogenic Mycobacteria of Humans and Animals

Dear Colleagues,

Mycobacterium tuberculosis is the number one, bacterial cause of human deaths worldwide. Currently available vaccines are effective mainly against childhood tuberculosis, and treatment requires months of multiple antibiotics, which have serious side effects. Despite numerous ongoing vaccine and antibiotic clinical trials, the field is outpaced by the development of antibiotic resistance and vaccine trial failures, and we are no closer to eliminating the disease than we were 20 years ago. Mycobacterial species also infect and cause disease in most other vertebrate species, with the potential for zoonotic transmission. A better understanding of how mycobacteria cause disease, and thwart vaccine and antibiotic efforts, is needed in order to achieve elimination. In this special issue, we invite you to submit a review or original research article related to virulence factors and mechanisms contributing to mycobacterial infection in humans and animals.

Prof. Frederick D. Quinn
Dr. Kaori Sakamoto
Guest Editors

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