Special Issue "Role of Bacterial Chromatin in Environmental Sensing, Adaptation and Evolution"
Deadline for manuscript submissions: closed (31 October 2019) | Viewed by 14912
Bacterial genomes are organized and compacted into a structure called the ‘nucleoid’ by a multitude of factors that include architectural proteins, DNA topology and macromolecular crowding. Due to interplay between genome organization and DNA transactions, these factors play specific and generic roles in processes such as transcription, replication, repair and chromosome segregation. Environmental signals that alter genome organization thus drive adaptive responses to changes in the environment. It has become clear that the genomic incorporation and maintenance of foreign DNA is facilitated by factors involved in silencing the expression of foreign DNA (xenogeneic silencing) until relieved by specific signals. In this light, the spatio-temporal organization of the genome is currently a topic of great interest, explored at both the cellular and molecular levels. At the same time, over the last years there has been increasing interest in genome organization in non-canonical model organisms, providing comparative perspectives, demonstrating unanticipated activities of proteins involved in shaping the nucleoid of these organisms and revealing novel architectural proteins. In this Special Issue of Microorganisms, we invite contributions concerning any aspect of bacterial genome organization, with a particular emphasis on the interplay between genome organization and DNA transactions, xenogeneic silencing and environmental sensing in model and non-model bacterial species.
Dr. Remus Dame
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