Special Issue "Molecular Mechanisms of Fungal Virulence and Commensalism"
Deadline for manuscript submissions: closed (31 March 2019)
Infectious diseases remain one of the most prevalent health threats worldwide. In the Western world especially opportunistic infections are on the rise. Particularly, in cases of immune deficiencies opportunistic fungal infections are a leading cause of morbidity and mortality for hospitalized patients, mostly due to inefficient diagnosis and treatment regimens. Notably, fungal diseases cause annual healthcare costs exceeding double-digit billions in USA and Europe. Hence, fungal infections represent a major socio-economic and clinical problem worldwide, and remain a high priority challenge for global healthcare provision.
Several new concepts for a better understanding and treatment of fungal disease have been developed recently. This includes a better understanding of the key mechanisms of host-pathogen interaction, both on the host and pathogen side. Particularly mechanisms of the innate immune system against fungal infections, as well as the immune evasion strategies of the fungal invader and the switch from a commensal behavior to invasive disease have been studied in great detail. In addition the role of the microbiome has been recognized and its function in the context of fungal disease has been analyzed recently. These studies have opened the door for new concepts in prevention and treatment of fungal infections. This is supported by the development of new diagnostic concepts based on Next Generation Sequencing technologies or novel biomarkers, which are currently in development for clinical application.
In this Special Issue of Microorganisms, we invite you to send contributions concerning all aspects related to molecular mechanisms of host-pathogen interaction in fungal disease. This includes contributions to host mechanisms of defense, as well as fungal evasion strategies, including the microbiome and its effects on fungal colonization and disease development. New concepts in diagnostics of fungal disease and in the development of new antifungals are appreciated as well.
Prof. Dr. Steffen Rupp
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Opportunistic Fungal Infections
- Host-pathogen interaction
- Cell wall
- Virulence factors
- Innate Immunity
- Immune Receptors