Special Issue "Shiga Toxin-Producing Escherichia coli"

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: 31 October 2019

Special Issue Editor

Guest Editor
Prof. Rodney A. Moxley

School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, 1880 N. 42nd Street, Lincoln, NE 68583-0905, USA

Special Issue Information

Dear Colleagues,

Globally, Shiga toxin-producing Escherichia coli (STEC) is an important cause of illness with about half of the cases attributed to foodborne exposure. STEC infection results in a spectrum of illnesses, namely, diarrhea, bloody diarrhea, and hemolytic-uremic syndrome (HUS). HUS is a potentially life-threatening sequela that occurs in a proportion of cases. Shiga toxin (Stx) is the main virulence factor produced by STEC, hence the name; however, STEC strains also must express adhesins to effectively colonize the intestines and cause severe illness. The outer membrane protein intimin (Eae) is the adhesin most often associated with severe disease; however, Eae-negative strains have also been incriminated in severe disease in which fimbria (e.g., aggregative adhesion fimbria) mediated intestinal adherence and colonization. STEC strains isolated from patients with disease or identified to contain genes that encode for key virulence factors (e.g., Stx, Eae) constitute a subset of STEC known as enterohemorrhagic E. coli (EHEC). STEC are diverse pathogens capable of acquiring new virulence genes on mobile genetic elements. The emergence of strains such as the hybrid enteroaggregative-enterohemorrhagic serotype O104:H4 that caused an epidemic in Europe in 2011 is a classic example of the threat posed by STEC. Research to elucidate factors underlying virulence and host susceptibility is needed to mitigate further outbreaks of disease caused by these organisms.

In this Special Issue, I invite review or original research articles related to STEC virulence or host factors contributing to infections in humans.

Prof. Rodney A. Moxley
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • STEC
  • EHEC
  • pathogenesis
  • virulence factors
  • bacteria - host interactions
  • shiga toxin
  • adherence
  • host response

Published Papers

This special issue is now open for submission.
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