Special Issue "Shiga Toxin-Producing Escherichia coli"
Deadline for manuscript submissions: 31 October 2019
Prof. Rodney A. Moxley
School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, 1880 N. 42nd Street, Lincoln, NE 68583-0905, USA
Globally, Shiga toxin-producing Escherichia coli (STEC) is an important cause of illness with about half of the cases attributed to foodborne exposure. STEC infection results in a spectrum of illnesses, namely, diarrhea, bloody diarrhea, and hemolytic-uremic syndrome (HUS). HUS is a potentially life-threatening sequela that occurs in a proportion of cases. Shiga toxin (Stx) is the main virulence factor produced by STEC, hence the name; however, STEC strains also must express adhesins to effectively colonize the intestines and cause severe illness. The outer membrane protein intimin (Eae) is the adhesin most often associated with severe disease; however, Eae-negative strains have also been incriminated in severe disease in which fimbria (e.g., aggregative adhesion fimbria) mediated intestinal adherence and colonization. STEC strains isolated from patients with disease or identified to contain genes that encode for key virulence factors (e.g., Stx, Eae) constitute a subset of STEC known as enterohemorrhagic E. coli (EHEC). STEC are diverse pathogens capable of acquiring new virulence genes on mobile genetic elements. The emergence of strains such as the hybrid enteroaggregative-enterohemorrhagic serotype O104:H4 that caused an epidemic in Europe in 2011 is a classic example of the threat posed by STEC. Research to elucidate factors underlying virulence and host susceptibility is needed to mitigate further outbreaks of disease caused by these organisms.
In this Special Issue, I invite review or original research articles related to STEC virulence or host factors contributing to infections in humans.
Prof. Rodney A. Moxley
Manuscript Submission Information
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- virulence factors
- bacteria - host interactions
- shiga toxin
- host response