Skip to Content

Diagnostics, Volume 16, Issue 8

2026 April-2 - 135 articles

Cover Story: Alzheimer’s disease disproportionately affects females, underscoring the importance of identifying sex-specific risk factors that may contribute to this disparity. Endogenous estradiol has been proposed to confer neuroprotection against Alzheimer’s disease; however, whether lifetime exposure to endogenous estradiol (LEE2) relates to early markers of dementia risk remains unclear. In this study of 1156 dementia-free postmenopausal females, LEE2 was not associated with objective or subjective cognitive outcomes, but longer LEE2 was associated with lower severity of behavioural and functional symptoms. These findings suggest that relationships between hormonal exposure and brain health may extend beyond cognition, supporting a broader framework for early risk detection in females. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (135)

  • Review
  • Open Access
1 Citations
1,223 Views
23 Pages

Current Melioidosis Diagnostic Landscape and Missed Opportunities in Biomarker Development

  • Sri Agung Fitri Kusuma,
  • Santi Rukminita Anggraeni,
  • Qurnia Wulan Sari and
  • Neng Tanty Sofyana

Background/Objectives: Melioidosis, caused by Burkholderia pseudomallei, is a severe tropical infectious disease associated with high mortality in endemic regions. Early diagnosis remains challenging because conventional diagnostic methods, including...

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Article
  • Open Access
1 Citations
656 Views
17 Pages

From Neurological Severity to Anatomical Burden: An Integrated Clinical–CT Model for Predicting In-Hospital Mortality in Adults with Penetrating Cranial Gunshot Injuries

  • Mustafa Emre Sarac,
  • Zeki Boga,
  • Ali Arslan,
  • Ümit Kara and ,
  • Mehmet Ozer,
  • Ali Harmanoğullarından and
  • Yurdal Gezercan
  • + 2 authors+ 0 author

Background/Objectives: Cranial gunshot injuries represent severe traumatic brain injuries associated with high mortality rates. This study investigated whether integrating clinical findings at admission, including GCS score and pupillary response, wi...

(This article belongs to the Special Issue Traumatic Brain Injury and Associated Neurological and Neuropsychiatric Disorders: Diagnosis/Prognosis and Therapeutics)
  • Review
  • Open Access
2 Citations
1,473 Views
19 Pages

Monitoring the Depth of Sedation During Gastrointestinal Endoscopy: A Narrative Review of Current Evidence and Clinical Recommendations

  • Sonia Elena Popovici,
  • Bogdan Miutescu,
  • Stelian Adrian Ritiu,
  • Tudor Voicu Moga and ,
  • Ioan Sporea,
  • Dorel Sandesc,
  • Ovidiu Bedreag,
  • Marius Păpurică,
  • Mădălina Butaș and
  • Alina Popescu
  • + 5 authors+ 0 author

Sedation and anesthesia are integral components of modern gastrointestinal endoscopy, enhancing patient comfort and procedural success while adding risks such as respiratory and cardiovascular complications. Accurate monitoring of sedation depth is e...

(This article belongs to the Special Issue New Insights into Gastrointestinal Endoscopy)
  • Article
  • Open Access
1 Citations
764 Views
16 Pages

A Deep Learning Model for IMMP-Based Residual Disease Monitoring in AML with Monocytic Differentiation

  • Jing Ding,
  • Huiying Qiu,
  • Chunling Zhang,
  • Weilin Liu and ,
  • Xinyi Jin,
  • Ting Xu,
  • Zongyue Lu,
  • Jiatao Lou and
  • Huidan Li
  • + 4 authors+ 0 author

Background: Acute myeloid leukemia (AML) with monocytic differentiation poses significant clinical challenges, including high relapse rates and chemotherapy resistance. Current morphological assessment is limited by inter-observer variability, low se...

(This article belongs to the Special Issue AI for Precision Diagnostics: Enhancing Accuracy, Accessibility, and Outcomes)
  • Article
  • Open Access
671 Views
11 Pages

Background/Objectives: Cardiovascular interventions require prolonged fluoroscopy, which increases the risk of radiation. Diagnostic Reference Levels (DRLs), set at the 75th percentile of the dose distribution, are vital benchmarks for dose optimizat...

(This article belongs to the Special Issue Advances in Cardiovascular and Vascular Imaging)
  • Article
  • Open Access
1 Citations
1,215 Views
22 Pages

Phonosurgical Treatment of Laryngeal Leukoplakia and Dysplasia: Results of Multidimensional Voice Diagnostics Including the VEM

  • Moonef Alotaibi,
  • Felix Caffier,
  • Ahmad S. A. Alghamdi,
  • Carla Azar and ,
  • Martin Kampmann,
  • Tadeus Nawka,
  • Dirk Mürbe and
  • Philipp P. Caffier
  • + 3 authors+ 0 author

Background/Objectives: Laryngeal leukoplakia and dysplasia carry a variable risk of malignant transformation. Although microlaryngoscopic excision is standard of care, data on voice function are limited. Multidimensional diagnostics, including the Vo...

(This article belongs to the Special Issue Diagnosis and Management in Otolaryngology 2026)
  • Article
  • Open Access
673 Views
16 Pages

Radiographic and Clinical Outcomes of Dual Mobility Total Hip Arthroplasty: A Retrospective Comparative Study from a Tertiary Centre

  • Monica Georgiana Roman,
  • Alexandru Lisias Dimitriu,
  • Elisa Georgiana Popescu,
  • Eduard Catalin Georgescu and ,
  • Liliana Mirea,
  • Razvan Ene and
  • Dragos Ene
  • + 2 authors+ 0 author

Background: Dual mobility (DM) total hip arthroplasty (THA) was introduced to reduce postoperative instability, one of the most frequent causes of revision after hip replacement. Its use has progressively expanded beyond revision surgery to selected...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
4 Citations
756 Views
11 Pages

Application of Long-Read Whole-Genome Sequencing to Clarify Genotypic–Phenotypic Discrepancies in Methicillin-Resistant Staphylococcus aureus

  • Jin Ho Jhang,
  • Kwangjin Ahn,
  • Dokyun Kim,
  • Seok Hoon Jeong and ,
  • Hyun Soo Kim,
  • Young Ree Kim,
  • Young Ah Kim,
  • Kyeong Seob Shin,
  • Jeong Hwan Shin and
  • Young Uh
  • + 14 authors+ 9 authors

Background/Objectives: The Korean Global Antimicrobial Resistance Surveillance System monitors bloodstream Staphylococcus aureus infections by combining antimicrobial susceptibility testing (AST) with conventional polymerase chain reaction (PCR). Con...

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Review
  • Open Access
6 Citations
2,099 Views
34 Pages

Point-of-Care Diagnostic Technologies for Antimicrobial Resistance: Principles, Platforms, Clinical Impact, and Future Directions

  • Nahed N. Mahrous,
  • Mohannad M. Fallatah,
  • Rawan A. Fitaihi,
  • Hala Aldahshan and ,
  • Areej A. Alhhazmi,
  • Samiyah Al-Khaldi,
  • Hussam Fallatah,
  • Abdulmajeed A. Althobaiti,
  • Abdulaziz Saleh Alkhoshaiban and
  • Yahya F. Jamous
  • + 7 authors+ 2 authors

Antimicrobial resistance (AMR) is an ever-growing threat to global healthcare. It is largely driven by delayed or inadequate pathogen identification and antimicrobial susceptibility testing in routine clinical workflows. By the time the clinician rec...

(This article belongs to the Special Issue Bacterial Infections and Antimicrobial Resistance: Diagnosis and Management)
  • Article
  • Open Access
1 Citations
799 Views
15 Pages

Accuracy of Modified Budin Views for the Femoral Neck Anteversion at Different Hip Abduction Angles: An Experimental Study on Dry Bones

  • Murat Yuncu,
  • Emre Mucahit Kartal,
  • Sacide Efsun Urger,
  • Levent Sarıkcıoglu and ,
  • Serkan Gurcan and
  • Ozkan Kose
  • + 1 author+ 0 author

Background/Objectives: The modified Budin radiographic technique is a practical alternative to CT for measuring femoral neck anteversion (FNA); however, the impact of hip abduction angle on its accuracy remains unclear. This experimental study examin...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
635 Views
16 Pages

Background: Critically ill cardiac patients who require invasive mechanical ventilation represent a high-risk population with persistently elevated in-hospital mortality, despite advances in cardiovascular and critical care management. Real-world dat...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Article
  • Open Access
705 Views
13 Pages

Clinical Predictors of Dosimetric Precedence for Deep Inspiratory Breath Hold Radiation Therapy for Breast Cancer

  • Alzahra’a Al Matairi,
  • Abdulla Alzibdeh,
  • Issa Mohamad,
  • Ramiz Abu-Hijlih and ,
  • Wafa Asha,
  • Fadwa Abdel Rahman,
  • Haitham Kanaan,
  • Soha Ahmad,
  • Hikmat Abdel-Razeq and
  • Fawzi Abuhijla
  • + 5 authors+ 0 author

Background/Objectives: Radiation therapy for left-sided breast cancer exposes the heart and lungs to incidental radiation, increasing long-term risk of cardiopulmonary morbidity. This study evaluated the dosimetric impact of DIBH compared with free b...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
2 Citations
760 Views
22 Pages

Background/Objectives: Cardiovascular diseases are the leading cause of death worldwide. Therefore, early diagnosis and treatment of these diseases are of critical importance. Stethoscopes are the easiest and fastest medical devices for the initial d...

(This article belongs to the Special Issue Artificial Intelligence in Biomedical Diagnostics and Analysis 2025)
  • Article
  • Open Access
3 Citations
1,354 Views
12 Pages

Impact of Total Laboratory Automation on Urine Culture Turnaround Time: A Comparative Study Between Manual Workflow and WASPLab™

  • Fizza Khalid,
  • Ahmed J. Alzahrani,
  • Hilal Mohammed,
  • Aymen Khalaf Allah Gamma and ,
  • Mohamed Elhadi Hassan,
  • Christy Poulose,
  • Azza ElSheikh,
  • Khalid Sumaily,
  • Ahmad Ali Alharbi and
  • Osamah T. Khojah
  • + 8 authors+ 3 authors

Background: Turnaround time (TAT) is a key performance indicator in clinical microbiology, particularly for urine cultures, which represent a high-volume workload and directly impact antimicrobial stewardship. Methods: This retrospective observationa...

(This article belongs to the Section Clinical Laboratory Medicine)
  • Review
  • Open Access
2 Citations
814 Views
14 Pages

Platelet-rich plasma (PRP) is widely used as a second-line treatment for chronic tendinopathy that persists despite structured conservative care, yet outcomes and imaging correlates remain heterogeneous. This review outlines PRP biology and preparati...

(This article belongs to the Special Issue Advances in Musculoskeletal Radiology)
  • Article
  • Open Access
1,198 Views
13 Pages

Shear-Dependent Agreement and Clinical Reclassification of Whole-Blood Viscosity Measurements: A Paired Comparison of Rheovis 2000A and Hemovister

  • Jongho Yi,
  • Hong-Geun Jung,
  • Seoung Joon Lee,
  • Tae-Young Kim and ,
  • Hahn Young Kim,
  • Kyeong Ryong Lee,
  • Hyun Suk Yang and
  • Mina Hur
  • + 3 authors+ 0 author

Background/Objectives: Whole-blood viscosity (WBV) is increasingly used in cardiovascular risk assessment; however, inter-device comparability may depend on shear-rate definition. We performed a paired comparison of two scanning capillary viscometers...

(This article belongs to the Special Issue Advances in Laboratory Markers of Human Disease—2nd Edition)
  • Article
  • Open Access
979 Views
16 Pages

Immediate vs. Delayed Implant Placement Following Alveolar Ridge Procedures with Xeno-Hybrid Bovine Bone Graft: A Retrospective Cohort with Operator-Level Comparison

  • Marius Meier,
  • Pascal Grün,
  • Tim Schiepek,
  • Pina Jankowski and ,
  • Anna Bandura,
  • Sebastian Fitzek,
  • Flora Turhani and
  • Dritan Turhani
  • + 3 authors+ 0 author

Background: In everyday practice, we observed an increased number of complications with a xeno-hybrid bovine graft in challenging cases, prompting a systematic review of timing strategies and the impact of the operator. Objective: To compare early sa...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Article
  • Open Access
1 Citations
795 Views
26 Pages

A Multi-Teacher Knowledge Distillation Framework for Enhancing the Robustness of Automated Sperm Morphology Assessment

  • Osman Emre Tutay,
  • Hamza Osman Ilhan,
  • Hakkı Uzun,
  • Merve Huner Yigit and
  • Gorkem Serbes

Background/Objectives: The manual analysis of sperm morphology, crucial for male infertility diagnosis, is subjective and time-consuming. Automated methods using deep learning, offer a promising alternative; however, standard deep models are prone to...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
1 Citations
697 Views
16 Pages

Ultrasound-Assessed Brachial Artery Flow-Mediated Dilation and Carotid Plaque Burden as Markers of Vascular Health in Relation to Weekly Physical Activity Duration in Older Adults

  • Michał Fułek,
  • Tomasz Harych,
  • Piotr Macek,
  • Katarzyna Fułek and ,
  • Krzysztof Kraik,
  • Barbara Dziadkowiec-Macek,
  • Jarosław Domaradzki,
  • Małgorzata Poręba,
  • Andrzej Wysocki and
  • Rafał Poręba
  • + 6 authors+ 1 author

Objectives: This study assessed the association between physical activity and vascular endothelial function and carotid atherosclerotic plaques in older adults using ultrasound imaging. Methods and Results: A total of 60 older adults were divided int...

(This article belongs to the Special Issue New Radiological, Electrocardiographic and Biochemical Cardiovascular Risk Factors in 2026)
  • Review
  • Open Access
1,279 Views
19 Pages

Zinner Syndrome: A Narrative Review of Imaging Findings with an Illustrative Case Report

  • Calin Schiau,
  • Roxana Pintican,
  • Simona Manole,
  • Andrei Roman and ,
  • Ioana Teofana Dulgheriu,
  • Delia Doris Donci,
  • Loredana Elisabeta Popa,
  • Anca Ileana Ciurea and
  • Ioana Bene
  • + 4 authors+ 0 author

Zinner syndrome is a rare congenital anomaly of the male genitourinary tract, characterized by the triad of unilateral renal agenesis, ipsilateral seminal vesicle cyst, and ejaculatory duct obstruction. Owing to its low prevalence and nonspecific cli...

(This article belongs to the Special Issue Optimization of Clinical Imaging: From Diagnosis to Prognosis, 2nd Edition)
  • Article
  • Open Access
2 Citations
1,505 Views
16 Pages

An Adaptive Deep Learning Framework for Multi-Label Chest X-Ray Diagnosis Using a Hybrid CNN–Transformer Architecture and Class-Wise Ensemble Fusion

  • Chi-Feng Hsieh,
  • Hsu-Hsia Peng,
  • Yu-Hsiang Tsai,
  • Chia-Ching Chang and ,
  • Cheng-Hsuan Juan,
  • Hsian-He Hsu and
  • Chun-Jung Juan
  • + 2 authors+ 0 author

Background/Objectives: To develop and externally evaluate a deep learning framework for multi-label thoracic disease classification on chest radiographs using hybrid convolutional neural network (CNN)–transformer architectures, hierarchical sca...

(This article belongs to the Special Issue Artificial Intelligence in Diagnostic Imaging)
  • Review
  • Open Access
897 Views
17 Pages

Dermoscopic Interface Features in Melanoma–Seborrheic Keratosis Collision Tumors: A Scoping Review with an Illustrative Case Report on Wood’s Lamp Dermoscopy

  • Alexandre Raphael Meduri,
  • Francesca Ambrogio,
  • Lucia Lospalluti,
  • Domenico Bonamonte and ,
  • Giulia Ciccarese,
  • Gerardo Cazzato,
  • William Andrew Rosato,
  • Paolo Romita,
  • Mario Della Mura and
  • Caterina Foti
  • + 6 authors+ 1 author

Background/Objectives: Collision tumors between seborrheic keratosis and melanoma represent a well-known diagnostic pitfall, particularly when the benign keratinocytic component constitutes the predominant portion of the lesion. In such cases, melano...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
951 Views
12 Pages

Diagnostic Accuracy of 2 cm Versus 4 cm Insertion Depth for Nasal Swabs for SARS-CoV-2 Rapid Antigen Testing—A Randomized Controlled Trial

  • Rasmus Eið Callesen,
  • Tobias Todsen,
  • Rebekka Consuelo Eið,
  • Sabrina Dandanell Stange and ,
  • Tobias Gredal,
  • Nikolai Kirkby,
  • Michael Papesch,
  • Christian von Buchwald and
  • Kathrine K. Jakobsen
  • + 4 authors+ 0 author

Background/Objectives: Optimal specimen collection is essential for accurate diagnostic tests for upper airway infections. Rapid antigen diagnostic tests (RDTs) are commonly used for SARS-CoV-2 testing, yet the optimal sampling depth remains unclear....

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Review
  • Open Access
4 Citations
1,662 Views
16 Pages

Global and Regional Diagnostic Results of Progress Toward Cervical Cancer Elimination, According to the WHO Strategy: A Systematic Literature Review with Narrative Synthesis

  • Dan Cristian Luca,
  • Ciprian Cirimbei,
  • Sinziana Octavia Ionescu,
  • Vlad Rotaru and ,
  • Dan Nicolae Straja,
  • Mihnea Alecu,
  • Elena Chitoran,
  • Daniela Cristina Stefan and
  • Laurentiu Simion
  • + 4 authors+ 0 author

Background/Objectives: In 2020, the World Health Organization (WHO) launched a strategy to eliminate cervical cancer by ensuring high vaccination coverage, effective screening, and access to treatment. This review assesses how this strategy has been...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
1,067 Views
30 Pages

Echocardiography Report Translation and Inference Based on Parameter-Efficient Fine-Tuning of LLaMA Models

  • Hsin-Ta Chiao,
  • Wei-Wen Lin,
  • Shang-Yang Tseng,
  • Yu-Cheng Hsieh and
  • Chao-Tung Yang

Background/Objectives: Echocardiography reports are essential diagnostic tools, but their complexity and specialized English terminology frequently hinder comprehension for non-specialists and patients. This study addresses these accessibility gaps b...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
1 Citations
875 Views
19 Pages

Radiomics in the Evaluation of Cystic and Neoplastic Lytic Lesions of the Jaws

  • Paola Di Giacomo,
  • Pasquale Frisina,
  • Alberto Fratocchi,
  • Pierluigi Barra and ,
  • Cira Rosaria Tiziana Di Gioia,
  • Flavia Adotti,
  • Giovanni Falisi,
  • Fabrizio Spallaccia,
  • Iole Vozza and
  • Daniela Messineo
  • + 7 authors+ 2 authors

Background/Objectives. Radiomics is an emerging imaging-based tool that enhances lesion characterization beyond conventional diagnostic approaches. Its potential in evaluating osteolytic lesions of the jaws lies in improving discrimination between be...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
1 Citations
909 Views
20 Pages

CT-Based Radiomic Signatures Associated with Serum CEA Status in Colon Cancer

  • Demet Doğan,
  • Coşku Öksüz,
  • Özgür Çakır and
  • Oğuzhan Urhan

Background/Objectives: Carcinoembryonic antigen (CEA) is widely used in colon cancer management; however, its diagnostic and prognostic accuracy is limited by biological variability, as well as false-positive or false-negative results. Radiomics prov...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
1 Citations
874 Views
14 Pages

Additional Diagnostic Yield of Endocervical Curettage in Type 3 Transformation Zone for High-Grade Cervical Lesions: A Retrospective Analysis by Human Papillomavirus Genotype

  • Elena Lavinia Rusu,
  • Victor Bogdan Buciu,
  • Lavinia Balan,
  • Denis Mihai Serban and ,
  • Jasmina Chiriac and
  • Veronica Daniela Chiriac
  • + 1 author+ 0 author

Background/Objectives: When the squamocolumnar junction is not fully visible (type 3 transformation zone), colposcopy-directed biopsy may under-sample endocervical disease. Endocervical curettage (ECC) is recommended in selected settings, but its inc...

(This article belongs to the Special Issue Diagnostic Progress in Gynecologic Oncology)
  • Case Report
  • Open Access
1 Citations
3,250 Views
26 Pages

Parry–Romberg Syndrome: Radioclinical Dissociation in a Paucisymptomatic Form and a Proposed Diagnostic Framework

  • Cristian Turlea,
  • Andrei I. Cucu,
  • Alexandru Carauleanu,
  • Roxana Covali and ,
  • Camelia Tamas,
  • Mihnea A. Popa,
  • Victor Constantinescu,
  • Anca P. Morosan,
  • Elena Porumb-Andrese and
  • Alexandru Nemtoi
  • + 9 authors+ 4 authors

Background and Clinical Significance: Parry–Romberg syndrome (PRS), also known as progressive hemifacial atrophy, is a rare disorder characterized by progressive unilateral hemifacial atrophy, with potential involvement of the cranial bones and...

(This article belongs to the Special Issue Neurological Disorders: Diagnosis and Management)
  • Article
  • Open Access
763 Views
18 Pages

Background/Objectives: Image quality of mammograms in breast cancer screening is strongly operator-dependent, particularly in the mediolateral oblique (MLO) projection where adequate visualisation of the pectoralis major muscle serves as a surrogate...

(This article belongs to the Special Issue Recent Advances in Breast Cancer Imaging 2026)
  • Article
  • Open Access
1 Citations
743 Views
28 Pages

Three-Dimensional Analysis of Facial Skeleton Textures in CBCT as an Early Warning Sign of Osteoporosis—A Pilot Study

  • Tomasz Wach,
  • Marcin Kozakiewicz,
  • Adam Michcik,
  • Marcin Kociołek and ,
  • Piotr Hadrowicz,
  • Piotr Szymor,
  • Krzysztof Dowgierd,
  • Michał Podgórski and
  • Raphael Olszewski
  • + 4 authors+ 0 author

Background: Osteoporosis is a prevalent condition characterized by low bone mass and altered microarchitecture, increasing fracture risk. Early detection remains challenging, as conventional methods such as DXA are limited to specialized settings and...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
637 Views
10 Pages

Background/Objectives: The prerequisite for diagnosing celiac disease (CD) in children without duodenal biopsy is a tissue transglutaminase antibody (TGA) level exceeding 10 times the upper limit of normal levels, along with a positive confirmatory a...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Article
  • Open Access
809 Views
21 Pages

Hyperparameter Optimization of Convolutional Neural Networks for Robust Tumor Image Classification

  • Syed Muddusir Hussain,
  • Jawwad Sami Ur Rahman,
  • Faraz Akram,
  • Muhammad Adeel Asghar and
  • Raja Majid Mehmood

Background/Objectives: The human brain is responsible for controlling various physiological functions, and hence, the presence of tumors in the brain is a major concern in the medical field. The correct identification and categorization of tumors in...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
775 Views
10 Pages

Leukocytosis at Presentation Is an Independent Predictor for Hemorrhage in Cerebral Cavernoma

  • Harun Asoglu,
  • Tim Lampmann,
  • Johannes Wach,
  • Mohammed Banat and ,
  • Marcus Thudium,
  • Hartmut Vatter,
  • Erdem Güresir and
  • Motaz Hamed
  • + 3 authors+ 0 author

Objective: Cerebral cavernous malformations (CCMs) are usually occult but can present with a symptomatic hemorrhage. Treatment recommendations for CCMs are still controversially discussed, as all CCMs have signs of chronic hemorrhage. The distinction...

(This article belongs to the Special Issue Neurological Diseases: Biomarkers, Diagnosis and Prognosis, 2nd Edition)
  • Article
  • Open Access
1 Citations
794 Views
20 Pages

Background: Neoadjuvant chemotherapy (NAC) is widely used in the management of stage I–III breast cancer, with tumor regression serving as an important surrogate for long-term outcome. Identifying reliable pathological biomarkers predictive of...

(This article belongs to the Special Issue Diagnosis, Treatment, and Prognosis of Breast Cancer)
  • Article
  • Open Access
1 Citations
603 Views
16 Pages

Background/Objectives: To evaluate the associations between corneal topographic irregularity, higher-order aberrations (HOAs), and posterior segment structural and microvascular parameters in keratoconus using optical coherence tomography (OCT) and O...

(This article belongs to the Special Issue Diagnostic Imaging in Ocular Surface)
  • Article
  • Open Access
532 Views
16 Pages

Report-Level Impact of DL Assistance on Teleradiology Quality Support for Brain Metastases: Real-World Clinical Practice at a Single Tertiary Center

  • Jieun Roh,
  • Hye Jin Baek,
  • Seung Kug Baik,
  • Bora Chung and ,
  • Kwang Ho Choi,
  • Hwaseong Ryu and
  • Bong Kyeong Son
  • + 2 authors+ 0 author

Objective: Existing deep learning (DL) studies on brain metastasis have largely focused on algorithm or reader performance in controlled settings, whereas its role in routine teleradiology quality support remains unestablished. We evaluated the repor...

(This article belongs to the Special Issue AI-Assisted Diagnostics in Telemedicine and Digital Health)
  • Article
  • Open Access
1,070 Views
23 Pages

Background/Objectives: Measures of excess body fat are often more informative for predicting health risk than body mass index (BMI) alone. With obesity prevalence increasing among young adults, this study evaluated whether adding dominant handgrip st...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Article
  • Open Access
542 Views
11 Pages

Evaluation of the Reliability of Radiographic and MRI Angles in Superior Femoral Epiphysiolysis: A Comparative Study

  • Wassim Ben Abdennebi,
  • Andreas Tsoupras,
  • Eugénie Barras,
  • Viola Sbampato and ,
  • Romain Dayer,
  • Giacomo De Marco,
  • Oscar Vazquez,
  • Christina Steiger,
  • Amira Dhouib and
  • Dimitri Ceroni
  • + 6 authors+ 1 author

Background/Objectives: Slipped Capital Femoral Epiphysis (SCFE) is a common, serious hip disorder in children and adolescents. Two-dimensional (2D) radiography is the gold standard for diagnosis but may not fully capture the deformity’s complex...

(This article belongs to the Special Issue Advances in Diagnostic Imaging and Interpretation in Pediatric Radiology)
  • Article
  • Open Access
1,238 Views
22 Pages

Molecular Diagnosis and Phenotypic Variability of Noonan Syndrome: Experience from a Romanian Multicenter Study

  • Florina Victoria Nazarie,
  • Mihaela Amelia Dobrescu,
  • Cecilia Lazea,
  • Ana Adriana David and ,
  • Crina Șufană,
  • Simona Bucerzan,
  • Simona Sorana Cainap,
  • Raluca Rancea,
  • Oana Stănoiu-Pînzariu and
  • Romana Vulturar
  • + 11 authors+ 6 authors

Background: RASopathies represent a clinically and genetically diverse group of syndromes resulting from germline mutations in genes regulating the RAS/mitogen-activated protein kinase (MAPK) signaling cascade. Methods: The aim of this study was to d...

(This article belongs to the Special Issue Genomics in Cardiac Diagnostics: Bridging Novel Insights to Clinical Practice)
  • Interesting Images
  • Open Access
678 Views
5 Pages

Lamellar ichthyosis is a rare congenital disorder of keratinization frequently associated with ocular complications, most commonly cicatricial ectropion and exposure keratopathy. We present a case of severe mixed exposure-related and neurotrophic ker...

(This article belongs to the Special Issue Advances in the Diagnostics and Management of Diseases of the Anterior Segment of the Eye)
  • Article
  • Open Access
1,169 Views
17 Pages

Correlation Between Advanced Glycation End Products and Ultrasonographic Measurements of Cervico-Facial Skin Tissue

  • Anida-Maria Babtan,
  • Claudia Feurdean,
  • Stefan Cristian Vesa,
  • Octavia Sabin and ,
  • Alexandra-Ioana Roşioară,
  • Sonia Irina Vlaicu,
  • Antonia Eugenia Macarie and
  • Aranka Ilea
  • + 3 authors+ 0 author

Background/Objectives: Advanced glycation end products (AGEs) accumulate in long-lived extracellular matrix proteins and have been implicated in skin aging and tissue remodeling, particularly in photo-exposed skin. High-frequency ultrasound (HFU) off...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
1 Citations
754 Views
21 Pages

Background/Objectives: Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive desmoplastic microenvironment; however, reproducible stromal-associated biomarkers linked to disease progression remain limited. This study therefore aime...

(This article belongs to the Special Issue Advances in Molecular Pathology and Imaging for Precision Diagnosis and Treatment of Tumors)
  • Article
  • Open Access
594 Views
12 Pages

Background: Idiopathic epiretinal membranes (iERMs) are treated with pars plana vitrectomy and epiretinal membrane peeling. Simultaneous internal limiting membrane (ILM) peeling could reduce the recurrent rate. We aimed to explore the anatomical and...

(This article belongs to the Special Issue Eye Disease: Diagnosis, Management, and Prognosis—2nd Edition)
  • Article
  • Open Access
1 Citations
906 Views
22 Pages

Background/Objectives: This study proposes CMT-BUSNet, a hybrid architecture integrating CNN, Mamba, and Transformer branches for breast ultrasound tumor segmentation with built-in explainability. Methods: CMT-BUSNet employs a CNN-anchored hierarchic...

(This article belongs to the Special Issue Artificial Intelligence in Medical Image Analysis and Clinical Decision Support)
  • Review
  • Open Access
1,112 Views
20 Pages

Chronic Cholecystitis: Anatomical Variants, Pediculitis, and a Candidate Preoperative Framework for Difficult Laparoscopic Cholecystectomy

  • Georgiana-Andreea Marinescu,
  • Sarmis Marian Sandulescu,
  • Dumitru Radulescu,
  • Oana Taisescu and ,
  • Emil-Tiberius Trasca,
  • Elena-Irina Caluianu,
  • Dorin Mercut,
  • Razvan Mercut,
  • Eleonora Daniela Ciupeanu-Calugaru and
  • Citto Taisescu
  • + 7 authors+ 2 authors

Preoperative risk stratification for laparoscopic cholecystectomy (LC) remains imperfect, particularly in patients with chronic inflammatory remodeling and biliary anatomic variants. Existing tools often focus on acute presentations or intraoperative...

(This article belongs to the Special Issue Endoscopy and Diagnostic Tools in Hepatobiliary and Pancreatic Diseases, Second Edition)
  • Article
  • Open Access
632 Views
16 Pages

Concordance and Prognostic Impact of Tumor–Stroma Ratio and Tumor-Infiltrating Lymphocytes in Preoperative Biopsies and Matched Surgical Specimens in Oral Squamous Cell Carcinoma

  • Michal Mozola,
  • Michal Herman,
  • Katerina Brachtlova,
  • Jaroslav Michalek and ,
  • Jana Zapletalova,
  • Zdenek Bednarik,
  • Michal Hendrych,
  • Richard Pink,
  • Peter Tvrdy and
  • Marketa Hermanova
  • + 5 authors+ 0 author

Background/Objectives: Tumor–stroma ratio (TSR) and tumor-infiltrating lymphocytes (TILs) were suggested as prognostic markers in oral squamous cell carcinoma (OSCC). Identification of markers assessable in preoperative biopsies that could guid...

(This article belongs to the Special Issue Current Diagnosis and Management of Oral Cancer: Challenges, Advances, and Multidisciplinary Integration)
  • Review
  • Open Access
1 Citations
1,282 Views
17 Pages

Imaging-Driven Risk Stratification and Endovascular Decision Pathways in Acute Pulmonary Embolism

  • Fabio Corvino,
  • Francesco Giurazza,
  • Massimo Galia,
  • Antonio Corvino and ,
  • Pierleone Lucatelli,
  • Antonio Basile,
  • Marcello Andrea Tipaldi,
  • Cristina Mosconi and
  • Raffaella Niola
  • + 4 authors+ 0 author

Acute pulmonary embolism (PE) is increasingly managed as a dynamic risk continuum in which imaging findings guide therapeutic escalation rather than merely confirm diagnosis. The principal challenge still remains normotensive patients with intermedia...

(This article belongs to the Special Issue Updates in Vascular and Endovascular Surgery: Pathology, Diagnosis and Management)
  • Interesting Images
  • Open Access
490 Views
3 Pages

One-sided dorsal onlay urethroplasty (Kulkarni technique) aims to preserve urethral vascularity by limiting urethral mobilization to a single side of the corpus spongiosum while maintaining contralateral vascular attachments. Although the theoretical...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
4 Citations
1,022 Views
20 Pages

Background: Lung cancer remains one of the leading causes of cancer-related mortality worldwide, primarily due to late diagnosis. Although machine learning (ML) techniques have been widely applied for lung cancer classification, many studies lack a f...

(This article belongs to the Special Issue AI for Precision Diagnostics: Enhancing Accuracy, Accessibility, and Outcomes)

of 3

XFacebookLinkedIn
Diagnostics - ISSN 2075-4418