Endoscopy and Diagnostic Tools in Hepatobiliary and Pancreatic Diseases, Second Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 402

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Department of Medicine, Gastroenterol & Digest Endoscopy Unit, Pancreas Institute, GB Rossi University Hospital, University of Verona, Verona, Italy
Interests: pancreatobiliary; endoscopy
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Special Issue Information

Dear Colleagues,

With the rapid advancement of technology, the diagnosis of hepatobiliary and pancreatic diseases is becoming more and more precise. The availability of new tools and devices—together with breakthroughs in the knowledge of the biological behavior of neoplastic diseases—is changing the role of diagnostic imaging and preoperative assessment, which is being implemented from purely diagnostic to prognostic and risk stratification scenarios. In the era of precision medicine, artificial intelligence, radiomics, advanced endoscopy, and new preoperative tissue acquisition procedures represent the future of hepatobiliary and pancreatic diagnostics.

In this Special Issue, we aim to highlight current developments, and we invite submissions of original research and comprehensive reviews on recent or new diagnostic methods/devices, or on advancements/new discoveries related to cross-sectional imaging, endoscopy, and the pathology of hepatobiliary and pancreatic diseases.

We aim for this Special Issue to be informative for gastroenterologists, endoscopists, radiologists, pathologists, and surgeons.

Dr. Stefano Francesco Crinò
Guest Editor

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Keywords

  • endoscopic ultrasound
  • eRCP
  • radiomics
  • tissue acquisition
  • artificial intelligence
  • magnetic resonance imaging
  • cholangioscopy
  • pancreatic cancer
  • pancreatic cysts
  • hepatocellular carcinoma
  • cholangiocarcinoma

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Published Papers (1 paper)

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Research

11 pages, 335 KB  
Article
Through-the-Needle Biopsy Revisited: How Patient Selection and Standardization Reduce Adverse Events in Pancreatic Cyst Evaluation
by Maria Cristina Conti Bellocchi, Maria Vittoria Teso, Sofia Spagnolo, Erminia Manfrin, Sokol Sina, Antonio Pea, Nicolò de Pretis, Roberto Salvia, Luca Frulloni and Stefano Francesco Crinò
Diagnostics 2025, 15(24), 3096; https://doi.org/10.3390/diagnostics15243096 - 5 Dec 2025
Viewed by 245
Abstract
Background/Objectives: Pancreatic cystic lesions (PCLs) are increasingly being detected due to the widespread use of cross-sectional imaging. Endoscopic ultrasound (EUS) is the preferred modality for evaluating their nature and malignancy risk, yet fluid analysis and cytology offer limited sensitivity. Through-the-needle biopsy (TTNB) [...] Read more.
Background/Objectives: Pancreatic cystic lesions (PCLs) are increasingly being detected due to the widespread use of cross-sectional imaging. Endoscopic ultrasound (EUS) is the preferred modality for evaluating their nature and malignancy risk, yet fluid analysis and cytology offer limited sensitivity. Through-the-needle biopsy (TTNB) has emerged as a more accurate diagnostic tool, though it is associated with higher adverse event (AE) rates. In 2021, our center implemented a selective TTNB protocol excluding frail or elderly patients and suspected IPMNs and standardizing the procedure to two passes, complete cyst aspiration, and selective antibiotic prophylaxis. This study aimed to compare AE rates before and after protocol implementation, evaluate safety factors including antibiotic use, and assess TTNB adequacy and diagnostic accuracy. Methods: We retrospectively analyzed consecutive patients referred for TTNB at AOUI Verona between March 2016 and March 2025, dividing them into two groups: before (Group A) and after (Group B) protocol adoption. Patients not punctured due to technical issues, lack of indication, or presumed pseudocystic nature were excluded. Results: Of 970 patients evaluated by EUS, 190 underwent TTNB (100 in Group A and 90 in Group B). Lesions were mainly located in the pancreatic body or tail, with a significantly larger size in Group B. The overall AE rate was 6.3%, significantly higher in Group A (11%) than in Group B (1%). Antibiotic prophylaxis was not associated with AE occurrence. TTNB adequacy was 88.9%, and diagnostic accuracy was 75.3%. Among 68 surgical cases, TTNB was accurate in 79.4%. Conclusions: A selective and standardized TTNB approach significantly reduces AEs while maintaining high adequacy and diagnostic accuracy. Full article
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