Diagnostic Imaging in Ocular Surface

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 540

Special Issue Editors


E-Mail Website
Guest Editor Assistant
Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel
Interests: myopia; optometry and vision science; vision science; clinical ophthalmology; corneal topography; biometry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to examine the transformative impact of diagnostic imaging on the evaluation of the ocular surface and contact lens fitting. It bridges cutting-edge technology with routine clinical applications to enhance patient care. Recent advancements have led to significant progress being made in imaging modalities, such as ultra-high-resolution optical coherence tomography (UHR-OCT) for detailed visualization of the corneal endothelium, tear meniscus, and film dynamics, advanced reflectometry techniques, and other high-resolution methods. These innovations provide exceptional resolution and quality that surpass much of the existing literature, unveiling novel applications that remain underexplored. Key topics include corneal topography and tomography in managing irregular astigmatism and keratoconus, scleral profilometry for customizing scleral lens designs, wavefront aberrometry for aberration-based fittings, in vivo confocal microscopy for detailed examination of ocular surface microstructures, artificial intelligence-driven imaging for automated assessment of tear film stability and lens fits, enhanced digital slit-lamp biomicroscopy for visualizing meibomian glands and lid margins, and innovative approaches to customizing freeform lenses using precise anterior segment scans. In recent years, artificial intelligence (AI) has begun to assume a prominent role in the fields of ophthalmology and optometry.

Its integration is expanding across the entire eye care profession, influencing both diagnostic and clinical practices. AI has significantly enhanced the accuracy of ocular disease detection and diagnosis, thereby contributing to more effective disease management. Consequently, the synergy between advanced imaging modalities and AI is poised to further elevate the standard of patient care and treatment outcomes. Furthermore, this Special Issue aims to address imaging's role in managing dry eye, meibomian gland dysfunction, allergic conjunctivitis, and post-traumatic irregularities. We invite submissions of original research, case studies, methodological innovations, and reviews from optometrists, ophthalmologists, and imaging specialists to foster interdisciplinary dialogue, stimulate innovation, and advance vision science for improved comfort, safety, and outcomes.

Dr. Nir Erdinest
Guest Editor

Dr. David Berkow
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ocular surface imaging
  • contact lens fitting
  • ultra-high-resolution oct
  • corneal topography
  • corneal tomography
  • scleral profilometry
  • wavefront aberrometry
  • in vivo confocal microscopy
  • artificial intelligence in eye imaging
  • meibomian gland imaging

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Other

16 pages, 23439 KB  
Case Report
Transmission Electron Microscopy Corneal Ultrastructure Study in Hematocornea of Corneal Transplant Graft
by Paul Filip Curcă, Laura Macovei, Ovidiu Mușat, Mihail Zemba, Valentin Dinu, Mihaela Gherghiceanu, Cătălina Ioana Tătaru and Călin Petru Tătaru
Diagnostics 2026, 16(6), 890; https://doi.org/10.3390/diagnostics16060890 - 17 Mar 2026
Abstract
Background and Clinical Significance: To our knowledge, there is a lack of electron microscopy studies in hematocornea since 1985, and more so for graft hematocornea after deep anterior lamellar keratoplasty (DALK). This study provides an ultrastructural characterization of hematocornea occurring in a [...] Read more.
Background and Clinical Significance: To our knowledge, there is a lack of electron microscopy studies in hematocornea since 1985, and more so for graft hematocornea after deep anterior lamellar keratoplasty (DALK). This study provides an ultrastructural characterization of hematocornea occurring in a DALK graft. Our study presents several limitations: single-case design and lack of control tissue. Case Presentation: The DALK graft with hematocornea was excised and introduced inside of the operating room in glutaraldehyde solution recipient. The graft was quickly cold-transported to light and transmission electron microscopy. Hematocornea in the DALK transplant graft resulted in features of stromal alteration and dysfunctional cellular clean-up response. The collagen lamellae ultrastructure was affected near electron-dense hem deposits. Two cellular aspects were observed: adaptation and degeneration. Electron-dense granules were found in keratocytes, which may exhibit cellular adaptations, such as vacuoles and phagosomes. Macropinocytosis may mechanistically explain ingestion of electron-dense granules, and dysfunctions in the macropinocytosis process may have led to cell degeneration. Cellular degeneration was marked by loss of organelle contour and loss of cellular membrane integrity (burst-cell aspect). Microscopic corneal alteration corresponded to macroscopic total loss of corneal transparency and elasticity. Conclusions: This study described lamellar ultrastructure alterations and dysfunctional cellular response in hematocornea of a DALK corneal transplant graft. Full article
(This article belongs to the Special Issue Diagnostic Imaging in Ocular Surface)
Show Figures

Figure 1

Back to TopTop