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Advances in the Diagnostics and Management of Diseases of the...
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Advances in the Diagnostics and Management of Diseases of the Anterior Segment of the Eye

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 1203

Special Issue Editor

Prof. Dr. Sang Beom Han

E-Mail Website
Guest Editor
Department of Ophthalmology, Kangwon National University School of Medicine, Kangwon National University Hospital, Chuncheon 24289, Republic of Korea
Interests: cornea; cataract; dry eye disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The rapid development of new diagnostic technology has enabled the more precise and reproducible assessment of changes in anterior segment structures, such as the cornea, conjunctiva, sclera, anterior chamber, and lens. The application of these technologies has become essential to better diagnosis in anterior segment disorders. The use of novel imaging devices has also contributed to the improvement of outcomes in cornea, cataract, and refractive surgery. Therefore, the introduction of new methods and devices could provide improved treatment outcomes, as well as enhanced diagnostic accuracy, in anterior segment disorders. The development of more reliable diagnostic criteria for anterior segment diseases, e.g., dry eye disease, could allow more accurate diagnosis, which may result in better monitoring and treatment in these diseases.

For this Special Issue, we welcome research or review papers addressing the diagnosis of anterior segment disorder. We also invite papers on devices or methods for the assessment or visualization of these disorders.

Prof. Dr. Sang Beom Han
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anterior segment disorder
  • cornea
  • cataract
  • anterior segment imaging
  • refractive surgery

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Published Papers (3 papers)

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12 pages, 1586 KB  
Article
Characterizing Visual Field Defects with Tangent Screen Perimetry in Organic Versus Non-Organic Pathologies
by Hyunmin Na, Jeong-Min Hwang, Hee Kyung Yang and Sang Beom Han
Diagnostics 2026, 16(6), 842; https://doi.org/10.3390/diagnostics16060842 - 12 Mar 2026
Viewed by 417
Abstract
Background/Objectives: Tangent screen perimetry is a valuable tool for detecting functional visual loss (FVL), which is suspected when the visual field fails to expand as expected with distance. However, there is currently a lack of research documenting the specific tangent screen patterns [...] Read more.
Background/Objectives: Tangent screen perimetry is a valuable tool for detecting functional visual loss (FVL), which is suspected when the visual field fails to expand as expected with distance. However, there is currently a lack of research documenting the specific tangent screen patterns produced by patients with organic visual loss (OVL), defined as visual field loss caused by identifiable structural or neurologic pathology. This study aims to characterize the visual field patterns observed in patients with organic and functional pathologies during tangent screen perimetry and evaluate its diagnostic efficacy in confirming FVL. Methods: Medical records of patients from Seoul National University Bundang Hospital between August 2009 and August 2019 were reviewed. All subjects underwent a comprehensive neuro-ophthalmologic examination with additional testing to confirm the diagnosis of OVL or FVL. A total of 126 eyes from 76 patients exhibiting visual field constriction within 30 degrees were included. The tangent ratio (TR) was defined as the average visual field (in radians) at a far distance (e.g., 2 m) divided by the average visual field at a near distance (e.g., 1 m). The visual field patterns and TR were analyzed, and the diagnostic value of TR in detecting FVL was determined. Results: The clover leaf pattern and reversal pattern were observed in 8.8% and 12.7% of FVL cases, respectively, whereas no such patterns were found in OVL cases (p = 0.002, p < 0.001). The TR varied from 0.50 to 1.06 (mean 0.77 ± 0.16) in OVL and from 0.33 to 1.03 (mean 0.65 ± 0.15) in FVL (p < 0.001). Younger age, a clover leaf pattern or reversal pattern on tangent screen perimetry, and a lower TR were significantly associated with FVL. Conclusions: Tangent screen perimetry is an effective adjunct for differentiating functional from organic visual field loss, particularly in cases of visual field constriction. Full article
(This article belongs to the Special Issue Advances in the Diagnostics and Management of Diseases of the Anterior Segment of the Eye)
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4 pages, 2614 KB  
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Bilateral Lipid Keratopathy Treated with Staged Penetrating Keratoplasty: Restoration of Corneal Transparency and Visual Function
by Wojciech Luboń and Mariola Dorecka
Diagnostics 2026, 16(10), 1551; https://doi.org/10.3390/diagnostics16101551 - 20 May 2026
Viewed by 78
Abstract
Lipid keratopathy is an uncommon corneal disorder characterized by stromal lipid deposition that may cause progressive corneal opacity and visual impairment. We report a case of advanced bilateral lipid keratopathy with severe visual-axis involvement. At presentation, best-corrected visual acuity (BCVA) was counting fingers [...] Read more.
Lipid keratopathy is an uncommon corneal disorder characterized by stromal lipid deposition that may cause progressive corneal opacity and visual impairment. We report a case of advanced bilateral lipid keratopathy with severe visual-axis involvement. At presentation, best-corrected visual acuity (BCVA) was counting fingers in the right eye and 0.1 Snellen (1.0 logMAR) in the left eye. Slit-lamp examination and anterior segment optical coherence tomography (AS-OCT) demonstrated dense stromal lipid deposits involving the visual axis in both eyes. The patient underwent staged bilateral penetrating keratoplasty, with procedures performed three months apart. Postoperatively, corneal transparency improved in both eyes. At 6 months, BCVA was 0.5 Snellen (0.3 logMAR) in the right eye and 0.7 Snellen (0.15 logMAR) in the left eye. Residual visual limitation was attributed mainly to coexisting cataract, and sequential cataract surgery was planned. Together, the clinical photographs and AS-OCT scans illustrate an uncommon presentation of visually disabling bilateral lipid keratopathy, characterized by dense central stromal lipid deposition involving both visual axes and profound preoperative visual loss. The case is clinically noteworthy because it combines severe bilateral disease, close clinical–tomographic correlation, and sequential penetrating keratoplasty performed as a staged visual rehabilitation strategy, resulting in restoration of graft clarity and meaningful visual improvement during postoperative follow-up. Full article
(This article belongs to the Special Issue Advances in the Diagnostics and Management of Diseases of the Anterior Segment of the Eye)
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5 pages, 6473 KB  
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Multimodal Anterior Segment Imaging of Severe Mixed Exposure-Related Neurotrophic Keratopathy with Marked Corneal Thinning in Lamellar Ichthyosis
by Wojciech Luboń, Małgorzata Luboń and Mariola Dorecka
Diagnostics 2026, 16(8), 1209; https://doi.org/10.3390/diagnostics16081209 - 17 Apr 2026
Viewed by 313
Abstract
Lamellar ichthyosis is a rare congenital disorder of keratinization frequently associated with ocular complications, most commonly cicatricial ectropion and exposure keratopathy. We present a case of severe mixed exposure-related and neurotrophic keratopathy with marked corneal thinning in a 61-year-old man with genetically confirmed [...] Read more.
Lamellar ichthyosis is a rare congenital disorder of keratinization frequently associated with ocular complications, most commonly cicatricial ectropion and exposure keratopathy. We present a case of severe mixed exposure-related and neurotrophic keratopathy with marked corneal thinning in a 61-year-old man with genetically confirmed lamellar ichthyosis. At presentation, the best-corrected visual acuity (BCVA) in the right eye was limited to hand motion (logMAR 2.3). Slit-lamp examination revealed a large central to inferocentral corneal ulcer measuring approximately 3 × 4 mm with severe stromal thinning in the setting of marked lower eyelid ectropion, incomplete eyelid closure, and chronic ocular surface exposure, while anterior segment optical coherence tomography (AS-OCT) demonstrated a minimal corneal thickness of approximately 165 µm. Microbiological swabs obtained from the conjunctival sac were negative, and no purulent discharge, hypopyon, or anterior chamber inflammatory reaction was present, making active infectious keratitis unlikely. Corneal sensitivity measured with Cochet–Bonnet esthesiometry at presentation, centrally and in all four peripheral quadrants of both eyes, was markedly reduced, more severely in the affected right eye, supporting the presence of a severe neurotrophic component contributing to impaired corneal healing. Intensive conservative therapy including preservative-free lubricants, dexpanthenol gel, autologous serum eye drops, topical insulin, prophylactic antibiotics, and systemic doxycycline was initiated. Serial AS-OCT imaging demonstrated progressive structural recovery, with corneal thickness increasing to 438 µm after one month of treatment and complete corneal epithelialization. The BCVA improved to 0.2 Snellen (0.7 logMAR). This case highlights the diagnostic value of multimodal anterior segment imaging in monitoring severe mixed keratopathy with advanced corneal thinning and demonstrates that intensive conservative therapy may stabilize the ocular surface and prevent corneal perforation in patients with lamellar ichthyosis. Full article
(This article belongs to the Special Issue Advances in the Diagnostics and Management of Diseases of the Anterior Segment of the Eye)
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