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Diagnostics
Special Issues
New Insights into Gastrointestinal Endoscopy
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New Insights into Gastrointestinal Endoscopy

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Biomedical Optics".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 621

Special Issue Editors

Dr. Paraskevas Gkolfakis

E-Mail Website
Guest Editor
1. Hepatogastroenterology Unit, Attikon University General Hospital, Athens, Greece
2. Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme University Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium
Interests: interventional endoscopy; ERCP; EUS
Special Issues, Collections and Topics in MDPI journals
Dr. Apostolis Papaefthymiou

E-Mail Website
Guest Editor
1. Gastroenterology and Hepatology Department, 404 General Military Hospital of Larissa, Larissa, Greece
2. Division of Gastroenterology, Cleveland Clinic, London, UK
Interests: pancreatobiliary medicine; upper GI medicine; interventional endoscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gastrointestinal endoscopy has advanced significantly in recent years, incorporating new devices, techniques, and technology, revolutionizing diagnosis and treatment. Enhanced endoscopic views and tools like digital chromoendoscopy, endo-microscopy, and AI have optimized visual diagnosis and sampling for luminal and pancreatobiliary pathologies. Therapeutic endoscopy has expanded, enabling minimally invasive endo-surgical interventions from the esophagus to the rectum, including bariatrics, full-thickness resections, and pancreatobiliary interventions in patients with altered anatomy. This Special Issue aims to summarize current diagnostic and therapeutic abilities and emerging approaches in GI endoscopy.

Dr. Paraskevas Gkolfakis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diagnosis
  • prognosis
  • gastrointestinal endoscopy
  • markers
  • clinical practice and patient care

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Published Papers (2 papers)

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Research

18 pages, 2543 KB  
Article
Patients’ Experiences of Diagnostic and Therapeutic High-Resolution Endoscopy in Treating Anal Squamous Intraepithelial Lesions: A Qualitative Study
by Peter Borch-Johnsen, Hanna Dubois, Peter T. Schmidt, Jonas Nygren and Gail Dunberger
Diagnostics 2025, 15(17), 2205; https://doi.org/10.3390/diagnostics15172205 - 30 Aug 2025
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Abstract
Background: Anal squamous cell carcinoma is a rare disease strongly associated with the human papillomavirus (HPV) and preceded by the premalignant anal squamous intraepithelial lesion (ASIL). High-resolution anoscopy (HRA) using a colposcope is considered the gold standard for detecting and managing ASIL. Despite [...] Read more.
Background: Anal squamous cell carcinoma is a rare disease strongly associated with the human papillomavirus (HPV) and preceded by the premalignant anal squamous intraepithelial lesion (ASIL). High-resolution anoscopy (HRA) using a colposcope is considered the gold standard for detecting and managing ASIL. Despite being recommended in current guidelines for anal cancer screening, HRA availability remains limited. Although generally well tolerated, concerns about follow-up adherence persist. We have developed an endoscopic technique using high-resolution flexible endoscopes for detection, resection, and screening of ASIL. Our previous research suggests that this method is effective and gentle, but patients’ experiences of this approach remain underexplored. The aim of this study was to explore patients’ experiences of endoscopic detection, treatment, and screening of anal squamous intraepithelial lesions. Method: A qualitative approach was used involving semi-structured interviews and abductive qualitative content analysis. The 32-item COREQ checklist guided the reporting of the study. All participants followed a standardized protocol for treatment and follow-up. Results: Analysis of 16 interviews (female n = 7, male n = 9, age 19–72 years) yielded four categories: a comforting encounter in an exposed situation (with four subcategories); impact on intimate relationships (with one subcategory); living with uncertainty (with four subcategories); and physical discomfort (with two subcategories). Conclusions: High-resolution endoscopy is a well-tolerated and effective diagnostic and therapeutic modality for ASIL. However, the psychological impact of HPV-related conditions highlights the need for appropriate psychosocial support. These findings underscore the importance of integrating patient-centered care principles into the implementation of novel diagnostic and therapeutic technologies. Full article
(This article belongs to the Special Issue New Insights into Gastrointestinal Endoscopy)
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11 pages, 1113 KB  
Article
Are Scoring Systems Useful in Predicting Mortality from Upper GI Bleeding in Geriatric Patients?
by Mustafa Zanyar Akkuzu and Berat Ebik
Diagnostics 2025, 15(17), 2173; https://doi.org/10.3390/diagnostics15172173 - 27 Aug 2025
Viewed by 217
Abstract
Background/Objectives: This study aimed to determine the in-hospital mortality rate after upper gastrointestinal (GI) bleeding in geriatric patients with comorbidities. Additionally, it sought to identify effective cut-off values for predicting high-risk patients using AIMS65 and Rockall scores and to assess the impact [...] Read more.
Background/Objectives: This study aimed to determine the in-hospital mortality rate after upper gastrointestinal (GI) bleeding in geriatric patients with comorbidities. Additionally, it sought to identify effective cut-off values for predicting high-risk patients using AIMS65 and Rockall scores and to assess the impact of oral anticoagulant and NSAID use on mortality. Methods: A retrospective cohort study was conducted on 64 patients aged 60 and above with at least one comorbidity who were admitted for upper GI bleeding between January 2023 and June 2024. AIMS65 and Rockall scores were calculated for each patient. The relationship between these scores, medication use, and mortality was analyzed using statistical methods, including ROC analysis and Kaplan–Meier survival curves. Results: The mean age was 77.6 years, and all patients had at least one chronic disease; 57.8% used medications increasing bleeding risk. In-hospital mortality was 18.7%, with no significant association for oral anticoagulants (p = 0.275) or NSAIDs (p = 0.324). Sepsis, heart failure, chronic renal failure, and malignancy were strongly linked to mortality in univariate analysis; multivariate analysis confirmed sepsis and malignancy as independent predictors, with a trend for heart failure. AIMS65 ≥ 2 (sensitivity 90.1%, AUC = 0.920) and Rockall ≥ 6 (sensitivity 91.7%, AUC = 0.822) were both effective in predicting mortality, with risk rising cumulatively with higher scores (p < 0.001). Conclusions: In-hospital mortality after upper GI bleeding is high in elderly patients with multiple comorbidities, mainly from sepsis, malignancy, and heart failure. AIMS65 and Rockall scores effectively predict mortality and may support earlier intervention. The small, high-risk cohort limits generalizability, underscoring the need for multicenter validation. Full article
(This article belongs to the Special Issue New Insights into Gastrointestinal Endoscopy)
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