Clinical Manifestations and Treatment of Autoimmune Diseases: 2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 135

Special Issue Editors


E-Mail Website
Guest Editor
Department of Translational Medicine, Via Solaroli 17, 28100 Novara, Italy
Interests: inflammation; immune response; molecular pathway; etosis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
Interests: rare immunological diseases; vasculitis; immunodeficiencies; connective tissue disease; leukocyte biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The first volume of this Special Issue was a great success, publishing 12 peer-reviewed articles of recognized high scientific value [https://www.mdpi.com/journal/life/special_issues/VP89JRZU6T]; therefore, we invite you to publish your research in the second volume of this Special Issue.

Autoimmunity is one of the most common ways in which the immune system can fail. The mechanisms by which the human immune system protects us and can harm us are complex and fascinating. Autoimmune diseases are numerous and involve any medical specialty, ranging from mild to serious, chronic and tumultuous conditions. The field of autoimmune diseases is particularly active; in recent years, many interesting discoveries have been made regarding disease classification criteria, biological markers of inflammation activity, and synthetic and biological therapies. A further boost to research in this context was driven by the SARS-CoV-2 pandemic and consequent vaccinations. This is a good time to draw state-of-the-art lines in this field. With this Special Issue, we aim to fill these gaps, at least in part, by inviting researchers to contribute to improving the understanding and treatment of autoimmune diseases step by step. Articles may include any topic related to autoimmunity, from the biology and physiology of the immune system to clinical diseases, autoimmunity as an epiphenomenon of other conditions, response to vaccines and therapy. I hope that this Special Issue is greeted with productivity and enthusiasm as everyone's help is needed to make further progress in this crucial topic of human health.

Dr. Stelvio Tonello
Dr. Daniele Sola
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • autoimmunity
  • immunobiology
  • vaccine
  • leucocytes
  • immune system

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

17 pages, 751 KiB  
Article
Efficacy of Cannabis Oil in Improving Subjective Sleep Quality in Systemic Sclerosis: A Prospective Placebo-Controlled Study
by Apichart So-ngern, Bungon Sripanichkulchai, Ajanee Mahakkanukrauh, Siraphop Suwannaroj, Patnarin Pongkulkiat, Tippawan Onchan, Somdej Kanokmedhakul and Chingching Foocharoen
Life 2025, 15(5), 727; https://doi.org/10.3390/life15050727 (registering DOI) - 30 Apr 2025
Abstract
Objective: We aimed to investigate the efficacy of cannabis oil in improving sleep quality, as evaluated using the Pittsburgh Sleep Quality Index (PSQI), in patients with systemic sclerosis (SSc) compared to placebo. Methods: An experimental investigation was conducted in patients with SSc aged [...] Read more.
Objective: We aimed to investigate the efficacy of cannabis oil in improving sleep quality, as evaluated using the Pittsburgh Sleep Quality Index (PSQI), in patients with systemic sclerosis (SSc) compared to placebo. Methods: An experimental investigation was conducted in patients with SSc aged 18–70 years. The treatment group received a cannabis preparation containing 2.7 mg/mL tetrahydrocannabinol (THC) and 2.5 mg/mL cannabidiol (CBD) sublingually for 4 weeks. Results: Twenty-seven participants were included in the study. One case was withdrawn due to a serious adverse event, leaving 13 participants in each group. The mean difference in PSQI scores decreased more in the treatment group than in the placebo group from baseline to post-treatment, but this difference was not statistically significant (p = 0.09). Increases in sleep duration were more frequently observed in the treatment group than in the placebo group, along with decreases in sleep disturbance, sleep medication use, and daytime dysfunction; however, these were not statistically significant. Conclusions: Cannabis oil showed some positive trends; however, our study did not provide conclusive evidence supporting the efficacy of cannabis oil in improving sleep quality. More rigorous studies are needed to confirm these findings and expand the clinical applicability of cannabinoids for sleep disorders. Full article
Show Figures

Figure 1

Back to TopTop