Orthopedic Disease Treatment and Management: Innovations, Challenges, and Future Directions

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 189

Special Issue Editor


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Guest Editor
Orthopedics and Traumatology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
Interests: orthopedic surgery; arthroplasty; musculoskeletal regeneration; orthopedic trauma

Special Issue Information

Dear Colleagues,

Orthopedic diseases represent a diverse and complex challenge in modern medicine, encompassing conditions ranging from degenerative joint diseases to complex musculoskeletal trauma and orthopedic infections. Recent advancements in biomaterials, surgical techniques, regenerative medicine, and personalized treatment strategies have revolutionized patient outcomes, and yet many clinical dilemmas persist. The integration of cutting-edge technologies, including artificial intelligence, 3D printing, and patient-specific implants, is reshaping this field, allowing for more precise, efficient, and durable orthopedic interventions.

This Special Issue will showcase pioneering research and clinical studies addressing both surgical and non-surgical approaches in orthopedic disease management. Topics of interest include minimally invasive and robotic-assisted surgeries, biomechanics-driven implant design, the role of biologics in musculoskeletal repair, and emerging strategies in infection control and osteoarticular reconstruction. Additionally, the impact of rehabilitation protocols, multidisciplinary collaborations, and perioperative optimization on functional recovery will be explored.

By bringing together global experts in orthopedic research and practice, this Special Issue will provide a platform for groundbreaking discoveries and evidence-based approaches that will shape the future of orthopedic care. We welcome high-quality original research, systematic reviews, and clinical studies that contribute to the evolution of treatment paradigms and patient-centered orthopedic care.

Dr. Mihnea Ioan Gabriel Popa
Guest Editor

Manuscript Submission Information

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Keywords

  • orthopedic surgery
  • musculoskeletal regeneration
  • biomaterials and implants
  • minimally invasive techniques
  • periprosthetic joint infections
  • regenerative medicine
  • biomechanics and implant design
  • orthopedic trauma and reconstruction
  • rehabilitation and functional recovery
  • AI and robotics in orthopedics

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Published Papers (1 paper)

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Review

21 pages, 695 KiB  
Review
Injectables in the Therapy of Mid-Portion Achilles Tendinopathy, a Descriptive Review
by Daniela Poenaru, Claudia Gabriela Potcovaru, Miruna Ioana Sandulescu, Mariana Constantinovici and Delia Cinteza
Life 2025, 15(5), 824; https://doi.org/10.3390/life15050824 - 21 May 2025
Abstract
Achilles mid-portion tendinopathy is defined as a painful thickening of the tendon, identified also on different imagistic examinations, occurring in sport people as well in inactively middle-aged individuals. The chronic and/or relapsing evolution interfere with daily living and alter the quality of life. [...] Read more.
Achilles mid-portion tendinopathy is defined as a painful thickening of the tendon, identified also on different imagistic examinations, occurring in sport people as well in inactively middle-aged individuals. The chronic and/or relapsing evolution interfere with daily living and alter the quality of life. Eccentric physical exercise is a cornerstone in her management and several injectable agents are used in clinical settings to reduce pain and improve function. According to the presumed pathogenic mechanisms, many classes of agents are in use: corticosteroids, protease inhibitors, sclerosing agents, pro-inflammatory agents, autologous products. The modalities of administration, either intra- or peritendon, the timing and number of sessions are displayed. Practical approach of chronic mid-portion Achilles tendinopathy consists of rest, tendon protection, eccentric exercise and therapeutical injections. The clinicians must choose between a spectrum of agents active on different pathogenic mechanisms, with benefits in the short and medium term. Future research may be focused on comparison between the different agents and on long term evolution. Full article
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