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Life
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Innovative Approaches in Dermatological Therapies and Diagnostics
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Innovative Approaches in Dermatological Therapies and Diagnostics

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 26 December 2025 | Viewed by 2345

Special Issue Editors

Dr. Federica Li Pomi

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Guest Editor
Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, 90127 Palermo, Italy
Interests: non-melanoma skin cancer; melanoma; photodynamic therapy (PDT); inflammatory diseases; dermoscopy; dermatology imaging; actinic keratosis
Dr. Francesco Borgia

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Guest Editor
Department of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, 98125 Messina, Italy
Interests: skin; basal cell carcinoma; squamous cell carcinoma; dermatology imaging; photodynamic therapy (PDT); phototherapy; skin cancer; biopsy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We invite you to contribute to our upcoming Special Issue on “Innovative Approaches in Dermatological Therapies and Diagnostics”, which Special Issue aims to explore recent advancements, innovative methodologies, and significant findings in the diagnosis and treatment of dermatological conditions.

For diagnostic innovations, potential topics include, but are not limited to, non-invasive diagnostic methods, such as dermoscopy and confocal microscopy; line-field confocal optical coherence tomography; and the emerging role of artificial intelligence in skin diagnostics.

Regarding therapeutic innovations, potential topics include the development of novel therapies for skin cancer treatment, the progress of biological drugs in treating inflammatory diseases, the growing use of new JAK inhibitors, and the use of plant-derived products for various dermatological conditions.

We encourage the submission of review articles, perspectives, or original research that explore innovative therapeutic strategies and diagnostic techniques across all areas of dermatology. We look forward to receiving your contributions and working together to advance our knowledge in this exciting field.

Dr. Federica Li Pomi
Dr. Francesco Borgia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dermatology
  • inflammatory diseases
  • skin cancer
  • non-invasive diagnosis
  • dermoscopy
  • confocal dermoscopy
  • targeted therapy
  • JAK inhibitors
  • biologics
  • artificial intelligence

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

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11 pages, 493 KiB  
Article
Infiltrative Basal Cell Carcinoma of the Head: Factors Influencing Bone Invasion and Surgical Outcomes
by Anđela Dimkić Milenković, Vladimir Milenković, Masa Petrovic, Ana Tomic, Aleksandar Matejic, Nina Brkic and Milan Jovanović
Life 2025, 15(4), 551; https://doi.org/10.3390/life15040551 - 28 Mar 2025
Viewed by 364
Abstract
Basal cell carcinoma (BCC) is the most prevalent form of skin cancer, with infiltrative subtypes presenting significant clinical challenges due to their aggressive behavior and potential for deep tissue and bone invasion. This study aimed to evaluate factors associated with bone infiltration and [...] Read more.
Basal cell carcinoma (BCC) is the most prevalent form of skin cancer, with infiltrative subtypes presenting significant clinical challenges due to their aggressive behavior and potential for deep tissue and bone invasion. This study aimed to evaluate factors associated with bone infiltration and surgical bone removal in patients with infiltrative BCC. A prospective cohort of 100 patients with histologically confirmed infiltrative BCC was analyzed retrospectively. Clinical, histopathological, and imaging data were assessed to identify predictors of tumor behavior. Tumor size, histological subtype, and disease duration emerged as significant factors associated with bone invasion and resection. Logistic regression analysis identified tumor length as the most significant predictor of both bone infiltration (OR = 1.102, p < 0.001) and surgical bone removal (OR = 1.105, p < 0.001). Aggressive subtypes, such as infiltrative and morpheaform BCC, were more likely to invade bone and exhibited higher recurrence rates. While these findings highlight the importance of early detection and individualized treatment strategies, the absence of data on sun exposure and urban-rural residency limits the broader applicability of the results. Future research addressing these variables will provide a more comprehensive understanding of BCC aggressiveness and improve clinical management of this malignancy. Full article
(This article belongs to the Special Issue Innovative Approaches in Dermatological Therapies and Diagnostics)
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14 pages, 1141 KiB  
Article
Relationship Between Infrared Thermography and Functional Parameters in the Lower Limbs of Hemiplegic Patients
by Alessio Cabizosu, Alberto López-López, Daniele Grotto and Josefina Maria Vegara-Meseguer
Life 2025, 15(4), 542; https://doi.org/10.3390/life15040542 - 26 Mar 2025
Viewed by 170
Abstract
Introduction: Reliable objective and non-invasive assessments of myotendinous alterations in patients with muscle tone disorders secondary to brain damage represent an important challenge in health science. The aim of this study was to observe the relationship between the skin temperature and the functional [...] Read more.
Introduction: Reliable objective and non-invasive assessments of myotendinous alterations in patients with muscle tone disorders secondary to brain damage represent an important challenge in health science. The aim of this study was to observe the relationship between the skin temperature and the functional response in the triceps suralis of hemiplegic patients in relation to the healthy control group. Methods: A descriptive observational study was conducted based on the STARD recommendations. A total of 26 volunteers, 13 participants with unilateral motor impairment and 13 healthy patients, participated and completed the study. Intragroup and intergroup clinical thermography tests were performed, and the results were compared in relation to the timed up and go test, pain threshold to pressure, and modified Ashworth scale. Results: Statistically relevant differences (p < 0.01) could be observed between the two groups in each test performed. Thermographic analysis revealed a difference in temperature between the healthy and affected sides in the inter- and intra-group comparisons. It was possible to observe statistically significant differences (p < 0.01) between limbs in the brain damage group (the side affected was at a lower temperature), while no such differences were observed between limbs in the healthy control group (p > 0.05). Conclusions: Our results confirmed that clinical thermography could be a potentially useful tool in the assessment of both structural and functional alterations of the musculoskeletal system in patients with chronic brain damage. Full article
(This article belongs to the Special Issue Innovative Approaches in Dermatological Therapies and Diagnostics)
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17 pages, 1615 KiB  
Article
Serum Levels of IL-6 and TNF-α, Salivary Morning Cortisol and Intensity of Psychological Stress in Patients with Allergic Contact Hand Dermatitis and Healthy Subjects
by Nives Pondeljak, Liborija Lugović-Mihić, Blaženka Ladika Davidović, Dalibor Karlović, Milena Hanžek and Marijana Neuberg
Life 2025, 15(3), 351; https://doi.org/10.3390/life15030351 - 24 Feb 2025
Viewed by 618
Abstract
Introduction: Allergic contact dermatitis (ACD) is a form of late hypersensitivity reaction of skin contact with allergens. As an inflammatory skin disease, ACD has a negative impact on the quality of life and there is a need to elucidate the etiopathogenetic factors of [...] Read more.
Introduction: Allergic contact dermatitis (ACD) is a form of late hypersensitivity reaction of skin contact with allergens. As an inflammatory skin disease, ACD has a negative impact on the quality of life and there is a need to elucidate the etiopathogenetic factors of the disease, whereby using the psychoneuroimmunological (PNI) approach can be helpful. Psychological stress (PS), as a component of PNI, leads to aggravation of the contact hypersensitivity reaction. In response to the perception of PS, cortisol secretion is enhanced by activation of the hypothalamic–pituitary–adrenal (HPA) axis. Furthermore, the pro-inflammatory cytokines interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) play a role in activating the HPA axis as well as initiating and maintaining inflammatory responses. Recent studies show that IL-6, IL-1, and TNF-α values are increased in the serum of patients with contact dermatitis, as well as in keratinocyte cell culture. Methods: The study examined the association of PNI factors (serum IL-6 and TNF-α, stress intensity with a Perceived Stress Scale (PSS) questionnaire, quality of life of dermatology patients with a Dermatology Life Quality Index (DLQI)) with the disease severity evaluated using the Hand Eczema Extent Score (HEES) and the duration of disease in hand ACD patients. Results: Patients with hand ACD had higher PSS (p = 0.001) than healthy people, with no difference in IL-6 and TNF-α. Higher DLQI was associated with higher HEES and PSS (p = 0.002 and p < 0.001) and these were the only predictors of DLQI. The duration of the disease was not related to the investigated factors. Conclusion: This study is the first so far, to our knowledge, in which a detailed analysis of PNI factors in patients with hand ACD was conducted. The results show that patients with ACD have higher PS intensity, which can chronically indicate changes in the balance of the HPA axis and indirectly affect the quality of life and disease severity of this disease. The results of the research provide more knowledge about hand ACD and contribute to and emphasize the importance of a multidisciplinary approach to treatment, thus improving the quality of life of these patients. Full article
(This article belongs to the Special Issue Innovative Approaches in Dermatological Therapies and Diagnostics)
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11 pages, 3176 KiB  
Brief Report
Navigating the Labial Artery: A Safer Approach to Submucosal Lip Filler Techniques
by Bruna S. F. Bravo, Leonardo G. Bravo, Beatriz G. Cornachini, Mariana C. Elias and Gabriel L. T. Alves
Life 2025, 15(4), 509; https://doi.org/10.3390/life15040509 - 21 Mar 2025
Viewed by 538
Abstract
Lip augmentation using hyaluronic acid (HA) fillers has become one of the most popular non-surgical aesthetic procedures, yet it is not without risks, particularly vascular complications. This study explores a novel vertical injection technique for submucosal placement of HA fillers, designed to enhance [...] Read more.
Lip augmentation using hyaluronic acid (HA) fillers has become one of the most popular non-surgical aesthetic procedures, yet it is not without risks, particularly vascular complications. This study explores a novel vertical injection technique for submucosal placement of HA fillers, designed to enhance safety and achieve natural-looking outcomes. Ten patients underwent lip augmentation using the proposed technique, which involved ultrasound-guided injections at predefined entry points to target intralabial compartments while minimizing the risk of labial artery injury. The results demonstrated high patient satisfaction, with significant improvements in lip volume and contour. The submucosal placement yielded subtle, natural results with fewer visible irregularities compared to superficial injections. No major complications, such as vascular occlusion, were observed, and minor side effects, including transient swelling and redness, resolved within 48 h. The use of ultrasound imaging allowed precise filler placement and reduced the risks associated with traditional horizontal injection paths parallel to the labial arteries. While the findings highlight the technique’s potential in terms of safety and efficacy, limitations include the small sample size, short-term follow-up, and the absence of a control group. Further studies with larger cohorts and comparative analyses are needed to validate long-term outcomes. This innovative approach underscores the importance of anatomical precision and advanced imaging technologies in enhancing safety and aesthetic outcomes in lip augmentation. Full article
(This article belongs to the Special Issue Innovative Approaches in Dermatological Therapies and Diagnostics)
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