Cells, Volume 9, Issue 4 (April 2020) – 277 articles
Cover Story (view full-size image): Despite decades of intensive research, the clinical translation of nanoparticle-based treatments remains relatively unexplored. Recent literature has criticized the lack of knowledge on interactions and fates of nanomaterials within living cells. Therefore, we investigated how lysosomal-mediated signaling is affected by iron oxide nanoparticles in hepatic cell lines. We found that alterations in the sub-cellular localization of p53 protein induced by nanoparticles greatly affected the autophagic flux. Our findings indicate that mild lysosomal dysfunction induced by nanoparticles promotes autophagy. Furthermore, cells with high levels of Bcl-2 were resistant to autophagy initiated by nanoparticles. Altogether, our data identify lysosomes as a central hub that control nanoparticle-mediated responses in hepatic cells. View this paper.
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