Role of STAT3 Signaling Pathway in Cancer

Dear Colleagues,

Signal transducers and activators of transcription (STATs) are a family of transcription factors that regulate cell proliferation, apoptosis, inflammation, and angiogenesis. The aberrant activation of STAT3 has long been strongly implicated in carcinogenesis. The activation of STAT3 involves the phosphorylation of its tyrosine-705 and serine-727 residues by various upstream kinases including Janus-activated kinases (JAKs), Src family kinases, and mitogen-activated protein (MAP) kinases. The phosphorylated STAT3 then dimerizes and translocates to the nucleus, where it binds to specific DNA response elements in the promoter regions of its target genes. The blockade of STAT3 activation inhibits cell proliferation and induces apoptosis. Thus, STAT3 is a prime target of many anticancer agents. Therefore, understanding the mechanisms that drive STAT3 signalling will be fundamental to our understanding of cancer, the development of novel therapeutic approaches, and ultimately to improved patient outcomes. In this Issue of Cells, “Role of STAT3 Signaling Pathway in Cancer”, experts are invited to contribute original research papers or review articles that will provide further insights on the functions of STAT3 in carcinogenesis.

Prof. Kyung-Soo Chun
Prof. Dae Joon Kim
Guest Editors

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