Gamma Delta T Cells (γδ T Cells) in Health and Disease: In Memory of Professor Wendy Havran
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 118912
Special Issue Editor
Interests: human gamma/delta T cells; T-cell activation; adoptive immunotherapy; tumor immunology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gamma/delta T cells differ from conventional alpha/beta T cells in that they recognize their ligands in an MHC/HLA-nonrestricted manner. Moreover, the germline repertoire of the gamma/delta variable T-cell receptor gene segments is much smaller compared to that of the alpha/beta T-cell receptor gene segments. Gamma/delta T cells recognize metabolites overproduced by stressed and transformed cells, as well as surface molecules upregulated upon cellular stress. Because of their potent anti-tumor activity, gamma/delta T cells have recently attracted much attention as effector cells for cancer immunotherapy. However, gamma/delta T cells also contribute to anti-infective immunity and are involved in autoimmunity. Increasing evidence also supports an important regulatory role of gamma/delta T cells in the interplay with other immune cells including alpha/beta T cells and dendritic cells. This Special Issue of Cells aims to provide an update of our current knowledge of the role of gamma/delta T cells under normal physiologic conditions as well as in diseases, including infectious diseases, autoimmunity, and cancer. Moreover, we welcome contributions which highlight the translational and therapeutic potential of gamma/delta T cells.
This Special Issue is dedicated to the memory of Prof. Wendy Havran, a pioneer in the field of gamma/delta T-cell research, who unexpectedly passed away on 20 January 2020. Dr. Havran made major contributions to the role of gamma/delta T-cell in local immune surveillance and epithelial immunity. She will remain with us, an outstanding member of the gamma/delta T-cell community, and a close friend to many of us.
Prof. Dr. Dieter Kabelitz
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- gamma delta T cells
- infectious diseases
- tumor immunology
- autoimmunity
- cellular immunotherapy
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.