The Emerging Role of MicroRNAs in NAFLD: Highlight of MicroRNA-29a in Modulating Oxidative Stress, Inflammation, and Beyond
Abstract
:1. Introduction
2. MiRs as Markers in Liver Disease
3. MiR-29a Functions as an Epigenetic Modifier to Mitigate Liver Injury
4. Role of miR-29a in Oxidative Stress and Inflammation
5. Role of miR-29a in Mitochondrial Metabolism
6. MiRNAs Involved in Lipid Metabolism of NALFD
7. The Role of miR-29a in Fibrogenesis
8. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Affected Pathway | Disease Model | miR-29a Targets | References |
---|---|---|---|
Epigenetics | NASH, liver fibrosis, HCC | DNMT3b, HDAC4, DNMT3a, TET1 | [37,38,39,40,41,42,43] |
Oxidative stress/Inflammatory | NASH, liver fibrosis, HCC | CD36, DNMT3b, HDAC4, ARRB1, PTEN | [37,40,44,45,46,47,48,49] |
Apoptosis | liver fibrosis, HCC | COL1A1, FGL2, MAP4K4, PDGFC, BCL-2, DNMT3a, MCL-1 | [42,46,48,50,51,52] |
Autophagy | NASH, liver fibrosis, HCC | DNMT3b, SPARC | [36,37,51] |
Epithelial-mesenchymal transition | NASH, liver fibrosis | COL1A1, FGL2, MAP4K4, PDGFC | [37,39,40,44,45,46,48,51,53] |
Cell cycle | HCC | SIRT1; SPARC; HULC, TET1, TET2, TET3 | [36,41,43,54,55] |
Cell migration | HCC | CLDN1, TET1, TET2, TET3, PTEN | [41,43,56] |
Source | Expression | Clinical Relevance | Reference |
---|---|---|---|
Plasma | Down | Biomarker implicated in miRFIB scoring algorithm for diagnosis of liver fibrosis | [31] |
Serum | Down | Reduced miR-29a along with elevated miR-122 serve as a diagnostic panel for NAFLD | [29] |
Serum | Down | negatively correlated with necroinflammation and liver fibrosis | [30] |
Serum | Down | Biomarker of advanced liver cirrhosis | [32] |
Serum | Up | Biomarker of HCC | [67] |
Plasma | Down | Prognostic marker of poor outcome of HCC | [33] |
Serum | Up | Predictor for poor survival of HCC | [70] |
HCC tissue | Up | Predictor for recurrence of HCC | [35] |
HCC tissue | Down | Prognostic marker of poor outcome of HCC | [55] |
HCC tissue | Down | Predictor for low survival rate of HCC | [36] |
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Lin, H.-Y.; Yang, Y.-L.; Wang, P.-W.; Wang, F.-S.; Huang, Y.-H. The Emerging Role of MicroRNAs in NAFLD: Highlight of MicroRNA-29a in Modulating Oxidative Stress, Inflammation, and Beyond. Cells 2020, 9, 1041. https://doi.org/10.3390/cells9041041
Lin H-Y, Yang Y-L, Wang P-W, Wang F-S, Huang Y-H. The Emerging Role of MicroRNAs in NAFLD: Highlight of MicroRNA-29a in Modulating Oxidative Stress, Inflammation, and Beyond. Cells. 2020; 9(4):1041. https://doi.org/10.3390/cells9041041
Chicago/Turabian StyleLin, Hung-Yu, Ya-Ling Yang, Pei-Wen Wang, Feng-Sheng Wang, and Ying-Hsien Huang. 2020. "The Emerging Role of MicroRNAs in NAFLD: Highlight of MicroRNA-29a in Modulating Oxidative Stress, Inflammation, and Beyond" Cells 9, no. 4: 1041. https://doi.org/10.3390/cells9041041