Special Issue "Regulation and Function of the Myc Oncogene"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (31 March 2020).
The MYC proto-oncoproteins, c-MYC, MYCN and MYCL, are structurally and functionally conserved transcription factors of the basic helix–loop–helix leucine zipper (bHLHZip) family. They are part of a complex transcriptional network involving other members of the bHLHZip family, including MAX and the MXD proteins. We have studied these proteins for more than 40 years, but still, there is much to learn. MYC proteins play fundamental roles in cell biology during development and cell division, including the regulation of metabolism, protein synthesis, cell adhesion, senescence, and apoptosis. In addition to specific gene regulation through the activation or repression of target genes, MYC is involved in general transcriptional amplification of already active promoters, leading to primary or secondary mRNA amplification. Furthermore, MYC proteins can mediate transcriptional-independent processes, such as DNA replication or mRNA cap methylation. Importantly, MYC genes are overexpressed, by means of translocation, amplification, increased translation or protein stability, in a wide range of human cancers and are frequently associated to aggressiveness and poor outcome. Several approaches to interfere with MYC activity have been explored, with so far limited applicability in the clinical setting. In this Special Issue of Cells, we aim to collect the current knowledge on this fascinating family of proteins, during health and disease in mammals as well as in other organisms. This includes all aspects of MYC biology, such as gene expression, protein stability and regulation, the manifold effects in cellular processes, and physiological control of stemness and tissue development. There will be a special focus on the pathological effects of MYC deregulation and the opportunities for therapeutic intervention in human disease, mainly cancer but also other MYC-associated syndromes.
We are looking forward to your contribution shedding light on this important and enigmatic protein and hope that together, we will bring the field forward!
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- MYC transcriptional network
- Development, cell cycle, and apoptosis
- Inhibition of MYC