Special Issue "Regulation and Function of the Myc Oncogene"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 9368
The MYC proto-oncoproteins, c-MYC, MYCN and MYCL, are structurally and functionally conserved transcription factors of the basic helix–loop–helix leucine zipper (bHLHZip) family. They are part of a complex transcriptional network involving other members of the bHLHZip family, including MAX and the MXD proteins. We have studied these proteins for more than 40 years, but still, there is much to learn. MYC proteins play fundamental roles in cell biology during development and cell division, including the regulation of metabolism, protein synthesis, cell adhesion, senescence, and apoptosis. In addition to specific gene regulation through the activation or repression of target genes, MYC is involved in general transcriptional amplification of already active promoters, leading to primary or secondary mRNA amplification. Furthermore, MYC proteins can mediate transcriptional-independent processes, such as DNA replication or mRNA cap methylation. Importantly, MYC genes are overexpressed, by means of translocation, amplification, increased translation or protein stability, in a wide range of human cancers and are frequently associated to aggressiveness and poor outcome. Several approaches to interfere with MYC activity have been explored, with so far limited applicability in the clinical setting. In this Special Issue of Cells, we aim to collect the current knowledge on this fascinating family of proteins, during health and disease in mammals as well as in other organisms. This includes all aspects of MYC biology, such as gene expression, protein stability and regulation, the manifold effects in cellular processes, and physiological control of stemness and tissue development. There will be a special focus on the pathological effects of MYC deregulation and the opportunities for therapeutic intervention in human disease, mainly cancer but also other MYC-associated syndromes.
We are looking forward to your contribution shedding light on this important and enigmatic protein and hope that together, we will bring the field forward!
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- MYC transcriptional network
- Development, cell cycle, and apoptosis
- Inhibition of MYC