Advances in Musculoskeletal Cell Therapy: Basic Science and Translational Approaches

Dear Colleagues,

The unstoppable progression of knowledge of the pathophysiological processes affecting bony, articular, and muscular structures allows for the continuous identification of new therapeutic targets and agents to be exploited in addressing the degenerative mechanisms affecting the musculoskeletal system.

The ultimate goal is to validate the results of in vitro studies in preclinical in vivo models, and subsequently translate the most promising therapies to clinical practice. The cutting-edge approaches are multiple, from the development of advanced in vitro models for the study of pathophysiological process to the implementation of cell-based therapies, including those that only involve cell paracrine activity or the combination of cells and scaffolds in tissue engineering approaches. In this context, progenitor cells, either stem or tissue specific, are fundamental as both actors and as in situ targets, due to their ability to promote a trophic and anti-inflammatory microenvironment.

The purpose of this Special Issue is to collect reports concerning advances in musculoskeletal cell therapy to drive researchers and clinicians towards innovative perspectives for the treatment of degenerative orthopaedic diseases.

Dr. Alessandra Colombini
Dr. Enrico Ragni
Dr. Silvia Lopa
Guest Editors

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