Special Issue "Cellular and Molecular Mechanisms underlying the Pathogenesis of Hepatic Fibrosis II"
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 83914
Special Issue Editor
Interests: cytokines; chemokines; signaling; animal models; biomarkers; hepatic stellate cells; therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The hallmark of hepatic fibrosis is the formation and deposition of excess fibrous connective tissue, leading to progressive architectural tissue remodeling. Irrespective of the underlying pathogenic cause (e.g., genetic disorders, viruses, alcohol, autoimmune attacks, metabolic disorders, cholestasis, venous obstruction, parasites), tissue damage induces an inflammatory response involving the local vascular system and the immune system and a systemic mobilization of endocrine and neurological mediators, ultimately leading to the activation of matrix-producing cell populations. In addition, excess fat and other lipotoxic mediators provoking endoplasmic reticulum stress, the alteration of mitochondrial function, oxidative stress, and modifications in the microbiota are associated with non-alcoholic fatty liver disease and, subsequently, the initiation and/or progression of hepatic fibrosis.
In this Special Issue of Cells, I invite you to contribute original research articles, reviews, or shorter perspective articles on all aspects related to the theme of “Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis”. Expert articles describing mechanistic, functional, cellular, biochemical, or general aspects of hepatic fibrogenesis are highly welcome. Relevant topics include but are not limited to:
- Cytokine signaling;
- Chemokine function;
- In vitro and in vivo models;
- Immunology in hepatic fibrosis;
- Extracellular matrix;
- Inflammation;
- Fibrosis;
- NASH/NAFLD;
- Alcohol;
- Hepatitis;
- Microbiota;
- Bioimaging;
- Translational medicine.
Prof. Ralf Weiskirchen
Guest Editor
Manuscript Submission Information
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