Special Issue "Cellular and Molecular Mechanisms underlying the Pathogenesis of Hepatic Fibrosis II"
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 83914
Interests: cytokines; chemokines; signaling; animal models; biomarkers; hepatic stellate cells; therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue in Livers: Hepatic Fibrosis: From Pathogenesis to Clinical Management
Special Issue in Journal of Clinical Medicine: Predictive Biomarkers in Critically Ill Patients: New Insights and Challenges
Special Issue in Livers: Signaling Pathways in Liver Fibrosis Process
Special Issue in Cells: Emerging Therapeutic Approaches for Chronic Liver Diseases
Special Issue in Cells: Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis III
Special Issue in International Journal of Molecular Sciences: Exploring Molecular Mechanisms of Liver Fibrosis
Special Issue in Livers: Liver Fibrosis: Mechanisms, Targets, Assessment and Treatment
Topics: Signaling Pathways in Liver Disease
The hallmark of hepatic fibrosis is the formation and deposition of excess fibrous connective tissue, leading to progressive architectural tissue remodeling. Irrespective of the underlying pathogenic cause (e.g., genetic disorders, viruses, alcohol, autoimmune attacks, metabolic disorders, cholestasis, venous obstruction, parasites), tissue damage induces an inflammatory response involving the local vascular system and the immune system and a systemic mobilization of endocrine and neurological mediators, ultimately leading to the activation of matrix-producing cell populations. In addition, excess fat and other lipotoxic mediators provoking endoplasmic reticulum stress, the alteration of mitochondrial function, oxidative stress, and modifications in the microbiota are associated with non-alcoholic fatty liver disease and, subsequently, the initiation and/or progression of hepatic fibrosis.
In this Special Issue of Cells, I invite you to contribute original research articles, reviews, or shorter perspective articles on all aspects related to the theme of “Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis”. Expert articles describing mechanistic, functional, cellular, biochemical, or general aspects of hepatic fibrogenesis are highly welcome. Relevant topics include but are not limited to:
- Cytokine signaling;
- Chemokine function;
- In vitro and in vivo models;
- Immunology in hepatic fibrosis;
- Extracellular matrix;
- Translational medicine.
Prof. Ralf Weiskirchen
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.