Cells, Volume 9, Issue 5 (May 2020) – 255 articles
Cover Story (view full-size image): Podocytes are terminally differentiated epithelial kidney cells and provide pivotal structures of the glomerular filter with their interdigitating foot processes. Glomerular hyperfiltration is a typical feature of several common forms of chronic kidney diseases exposing podocytes to increased fluid flow shear stress. Activation of the autocrine/paracrine cyclooxygenase 2 (Cox2)/prostaglandin E2 (PGE2) pathway associates with podocyte damage in this setting. Using distinct analysis of cellular PGE2 and its metabolites by liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI‐MS/MS), a concerted action involving PGE2 signaling via both PGE2 receptor type 2 (EP2) and type 4 (EP4) in the COX2/PGE2 pathway was identified in human podocytes. View this paper
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