Table of Contents
Cells, Volume 9, Issue 3 (March 2020) – 266 articles
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Cover Story (view full-size image) Macrophages (MPs) are crucial for tissue regeneration/repair. In skeletal muscle, MPs adopt a [...] Read more. Macrophages (MPs) are crucial for tissue regeneration/repair. In skeletal muscle, MPs adopt a pro-inflammatory phenotype that stimulates a proliferation of myogenic cells and then switches to an anti-inflammatory status that induces myogenic differentiation. The phagocytosis drives this phenotypical switch. We show that the transcription factor Nfix is expressed by MPs and required for the pro-inflammatory to anti-inflammatory switch. Upon acute injury, a delay of muscle regeneration was evident in mice where Nfix has been deleted in the myeloid line. Moreover, phagocytosis induced by the inhibition of the RhoA-ROCK1 pathway leads to Nfix expression and the acquisition of the anti-inflammatory phenotype. We identified Nfix as a link between RhoA-ROCK1-dependent phagocytosis and the MP phenotypical switch, thus establishing a new role for Nfix in macrophage biology for tissue recovery. View this paper.