Special Issue "Metabolic Rewiring in Cancer Cells: From Tumor Onset to Novel Therapies"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (30 October 2020).
Interests: cancer proteomics; breast cancer; BRCA1, plasma biomarkers; mitochondria; metabolic rewiring in cancer; HIF-1α in breast cancer
Special Issues and Collections in MDPI journals
Interests: cancer cell metabolism; metabolic rewiring in cancer; metabolic targeting in cancer therapy; mitochondria and cancer; PKA in cancer; hexosamine biosynthetic pathway in cancer growth and drug resistance; cancer cells computational models
Cancer cells exhibit common hallmarks consisting of specific competencies acquired during tumorigenesis process, including stimulus of cancer cells proliferation, insensitivity to growth signals inhibition, apoptosis evasion, enhancement of replicative potential, induction of angiogenesis, and tissue invasion and metastasis. To sustain the high rate of proliferation, most cancer cells use metabolic adaptations promoting their survival under harsh conditions. These phenomena are known as metabolic rewiring.
In cell transformation, arising in different cell types through the dysregulation of several pathways, metabolic rewiring is a common feature founded on three main requirements: (1) ATP generation, (2) synthesis of biological precursors for sustaining cell growth, and (3) efficient handling of reactive oxygen species (ROS) for the maintenance of oxidative balance. More recently, cancer metabolic alterations have been shown to play a role in the sensitivity of cancer cells to the most-used chemotherapeutics, suggesting that cancer metabolic rewiring is an important mediator of drug resistant cancer.
Cancer cellular rewiring is the result of an intricate network of classic cancer metabolic pathways and a plethora of emerging dysregulated pathways supporting cell proliferation including: increased uptake of nutrients, enhanced glycolysis, enhanced shunt of pentose phosphate, glutaminolysis, fatty acid synthesis and degradation, stimulation of autophagy, micropinocytosis, and gene expression alterations depending on histones metabolic changes.
The redundancy and overlapping of several of these networks account for plasticity that is crucial for cancer cell survival.
More evidence is suggesting that the tumor microenvironment plays a key role in metabolic rewiring, indicating that the understanding the interaction between specific tumor-intrinsic mechanisms and cells-extrinsic stimuli might elucidate the pathways that lead to immune evasion.In summary, although our understanding of cancer metabolic rewiring has considerably progressed, much remains to learn to better understand tumor biology and improve therapeutic approaches.
The elucidation of pathways underlying metabolic reprogramming will have a tremendous impact by shedding light on therapeutic targets useful for developing new translational clinical approach. From this perspective, the purpose of this Special Issue is to gather reports further defining previous and/or newly discovered metabolic alterations associated with oncogenesis and their functional contribution to the establishment and maintenance of tumor phenotype as well as papers reporting the potential druggability of metabolic pathways, alone or in combination with other currently used chemotherapeutics, to improve cancer therapy.
Dr. Domenica Scumaci,
Prof. Ferdinando Chiaradonna,
- metabolic reprogramming
- targeted therapy
- mitochondria epigenetics
- nuclear epigenetics
- combined therapy
- modeling cancer metabolic rewiring
- 3D cell models of cancer metabolism
- In silico model of cancer metabolism