Special Issue "The Molecular and Cellular Basis for Lupus"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (29 February 2020) | Viewed by 45181
Interests: systemic lupus erythematosus; inflammation; autoimmunity; T cells; cognition; meta-analyses
Special Issues, Collections and Topics in MDPI journals
Systemic lupus erythematosus (SLE) is an autoimmune condition with a complicated pathophysiology that is not completely understood. While many molecular pathways and cellular alterations have been postulated and published in the literature, a number of clinical trials addressing these potentially pathological mechanisms have disappointingly failed to reach their respective primary endpoints, leading to the current paucity of targeted therapeutic agents that are capable of decelerating and even terminating the disease process and damage.
Nevertheless, some early and promising signals such as the success of the manipulation of the BAFF/ARPIL system, antagonization of IL-12/23 and the use of IL-2 in the management of SLE are currently in the pipeline for further evaluation for the clinical management of SLE. Obviously, these potential successes will not materialize if the basic molecular and cellular mechanisms of these new targets that are involved in the pathophysiology of SLE are not fully explored, vigorously tested and meticulously monitored.
This Special Issue of Cells aims to summarize the cutting-edge knowledge on the molecular and cellular basis of the pathogenesis and pathophysiology of SLE, in the hope of expanding the treatment armamentarium and ultimately, personalized treatment for patients with SLE.
We are looking forward to your significant contributions.
Dr. Anselm Mak
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Signaling pathways related to SLE
- Molecular alterations related to SLE
- Cell-surface, cytosolic and nuclear-membrane receptors related to SLE
- SLE-related cytokines and chemokines in SLE
- Cell–cell interactions in SLE
- Mechanisms of organ involvement and damage in SLE