The Multifaceted Nature of Epithelial to Mesenchymal Transition (EMT): From Embryonic Development to Cellular Plasticity in Normal Tissue and Tumors
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".
Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 102228
Special Issue Editors
Interests: extra-cellular matrix (ECM) turn-over and remodeling; matrix–metalloproteinases (MMPs) and TIMPs; heparanase; tumor invasiveness and metastasis; epithelial to mesenchymal transition (EMT); SPATA2 (spermatogenesis-associated protein 2)
Special Issues, Collections and Topics in MDPI journals
2. Division of Nephrology and Dialysis, Department of Medicine, University of Verona, Piazzale A. Stefani 1, 37126 Verona, Italy
Interests: heparanase; organ fibrosis; inflammation; renal physiology; renal pathology; acute and chronic renal injury; epithelial to mesenchymal transition (EMT); molecular mechanisms in cancer progression
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The Epithelial to Mesenchymal Transition (EMT) was originally described during embryonic development and later was observed in several pathological events, including tissue fibrosis, tumor invasiveness, and metastasis. During EMT, epithelial cells lose adhesion junctions and apical–basal polarity and acquire a mesenchymal phenotype with an enhanced motility. EMT can be considered as a continuum, whereby cells exhibit epithelial, intermediate, and mesenchymal phenotypes, thus contributing to cells’ heterogeneity. Various studies on fibrosis and tumor experimental models strongly support the notion that EMT is a key mechanism for these pathological events. However, the real impact of the EMT on the progression of these disorders is still far from fully understood. In this Special Issue, the focus will be the identification of signaling pathways leading to the activation of EMT programs during physiological and pathological processes in order to provide new knowledge on the plasticity of cellular phenotypes and possible therapeutic interventions.
Prof. Maurizio Onisto
Dr. Valentina Masola
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- epithelial to mesenchymal transition (EMT)
- tumor-associated EMT
- mesenchymal to epithelial transition (MET)
- cancer stem cells
- tumor migration and metastasis
- EMT and fibrosis
- TGF-b and EMT induction
- EMT and embryonic development
- EMT and extracellular matrix (ECM) degradation
- EMT and epigenetic control
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.