The Multifaceted Nature of Epithelial to Mesenchymal Transition (EMT): From Embryonic Development to Cellular Plasticity in Normal Tissue and Tumors
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".
Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 100095
Special Issue Editors
Interests: extra-cellular matrix (ECM) turn-over and remodeling; matrix–metalloproteinases (MMPs) and TIMPs; heparanase; tumor invasiveness and metastasis; epithelial to mesenchymal transition (EMT); SPATA2 (spermatogenesis-associated protein 2)
Special Issues, Collections and Topics in MDPI journals
2. Division of Nephrology and Dialysis, Department of Medicine, University of Verona, Piazzale A. Stefani 1, 37126 Verona, Italy
Interests: heparanase; organ fibrosis; inflammation; renal physiology; renal pathology; acute and chronic renal injury; epithelial to mesenchymal transition (EMT); molecular mechanisms in cancer progression
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The Epithelial to Mesenchymal Transition (EMT) was originally described during embryonic development and later was observed in several pathological events, including tissue fibrosis, tumor invasiveness, and metastasis. During EMT, epithelial cells lose adhesion junctions and apical–basal polarity and acquire a mesenchymal phenotype with an enhanced motility. EMT can be considered as a continuum, whereby cells exhibit epithelial, intermediate, and mesenchymal phenotypes, thus contributing to cells’ heterogeneity. Various studies on fibrosis and tumor experimental models strongly support the notion that EMT is a key mechanism for these pathological events. However, the real impact of the EMT on the progression of these disorders is still far from fully understood. In this Special Issue, the focus will be the identification of signaling pathways leading to the activation of EMT programs during physiological and pathological processes in order to provide new knowledge on the plasticity of cellular phenotypes and possible therapeutic interventions.
Prof. Maurizio Onisto
Dr. Valentina Masola
Guest Editors
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Keywords
- epithelial to mesenchymal transition (EMT)
- tumor-associated EMT
- mesenchymal to epithelial transition (MET)
- cancer stem cells
- tumor migration and metastasis
- EMT and fibrosis
- TGF-b and EMT induction
- EMT and embryonic development
- EMT and extracellular matrix (ECM) degradation
- EMT and epigenetic control
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