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Special Issue "GTPase Pathways in Health and Diseases"
Deadline for manuscript submissions: closed (31 January 2020).
Interests: small GTPases; drugs and inhibitors; signaling pathways; cancer genetics and biology; therapeutic strategies
Interests: Rho GTPase signaling; cell migration; cytoskeletal dynamics; axon guidance; cancer metastasis
Small GTPases are a family of low-molecular-weight GTP-hydrolyzing enzymes that cycle between an inactive state when bound to GDP and an active state when associated with GTP. Small GTPases regulate key cellular processes (e.g., cell differentiation, proliferation, and motility) as well as subcellular events (e.g., vesicle trafficking), making them key participants in a great array of pathophysiological processes. Indeed, the dysfunction and deregulation of certain small GTPases have been related to the promotion and progression of cancer. It is believed that an in-depth study on the functional mechanism of small GTPases can provide a potential therapeutic strategy for cancer treatment.
In this Special Issue, we invite you to contribute original research articles, reviews, or shorter “perspective” articles on all aspects related to the theme of “The Small GTPase Pathways in Cancer Treatment”. We hope to highlight current trends and challenges with functional insights of these pathways from cellular and molecular perspectives, as well as the potential applications and therapeutic benefits of cancer treatment.
Dr. Yong Teng
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- small GTPases
- drug targets
- cancer biology
- treatment strategy